Detailed information for compound 1456511

Basic information

Technical information
  • TDR Targets ID: 1456511
  • Name: N-cyclohexyl-1-ethyl-3-[4-(4-methoxyphenyl)pi perazine-1-carbonyl]-N-methyl-4-oxoquinoline- 6-sulfonamide
  • MW: 566.712 | Formula: C30H38N4O5S
  • H donors: 0 H acceptors: 4 LogP: 4.25 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCn1cc(C(=O)N2CCN(CC2)c2ccc(cc2)OC)c(=O)c2c1ccc(c2)S(=O)(=O)N(C1CCCCC1)C
  • InChi: 1S/C30H38N4O5S/c1-4-32-21-27(30(36)34-18-16-33(17-19-34)23-10-12-24(39-3)13-11-23)29(35)26-20-25(14-15-28(26)32)40(37,38)31(2)22-8-6-5-7-9-22/h10-15,20-22H,4-9,16-19H2,1-3H3
  • InChiKey: XJZISEIPTZEARA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-cyclohexyl-1-ethyl-3-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-N-methyl-4-oxo-quinoline-6-sulfonamide
  • N-cyclohexyl-1-ethyl-3-[[4-(4-methoxyphenyl)-1-piperazinyl]-oxomethyl]-N-methyl-4-oxo-6-quinolinesulfonamide
  • N-cyclohexyl-1-ethyl-4-keto-3-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-N-methyl-quinoline-6-sulfonamide
  • N-cyclohexyl-1-ethyl-3-[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl-N-methyl-4-oxo-quinoline-6-sulfonamide
  • C519-1714
  • NCGC00109104-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0153 0.3732
Echinococcus multilocularis GPCR, family 2 0.0143 0.2953 0.3248
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0143 0.2953 0.3281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Loa Loa (eye worm) ctsf protein 0.002 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0409 1
Onchocerca volvulus 0.002 0.0153 0.1447
Schistosoma mansoni hypothetical protein 0.0143 0.2953 0.4382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0153 0.3732
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0153 0.0226
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0143 0.2953 0.3248
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0844 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1449 1
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2523 0.3744
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.6206 0.6895
Leishmania major hypothetical protein, conserved 0.0051 0.0844 0.5697
Leishmania major cathepsin L-like protease 0.0077 0.1449 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.6738 0.6738
Loa Loa (eye worm) latrophilin receptor protein 2 0.0143 0.2953 0.2953
Leishmania major cathepsin L-like protease 0.0077 0.1449 1
Loa Loa (eye worm) hypothetical protein 0.0452 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0153 0.3732
Brugia malayi Cathepsin L-like precursor 0.002 0.0153 0.0153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0409 0.2596
Leishmania major cathepsin L-like protease 0.002 0.0153 0.0773
Schistosoma mansoni survival motor neuron protein 0.0058 0.102 0.1514
Leishmania major cathepsin L-like protease 0.002 0.0153 0.0773
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0153 0.0153
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0153 0.0153
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0143 0.2953 0.2953
Loa Loa (eye worm) hypothetical protein 0.0143 0.2953 0.2953
Entamoeba histolytica cysteine protease, putative 0.002 0.0153 0.3732
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0844 1
Brugia malayi Flap endonuclease-1 0.0031 0.0409 0.0409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0044 0.5
Onchocerca volvulus 0.002 0.0153 0.1447
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0153 0.3732
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0844 0.5697
Brugia malayi Cathepsin L-like precursor 0.002 0.0153 0.0153
Leishmania major cathepsin L-like protease 0.002 0.0153 0.0773
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0153 0.3732
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0153 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0153 0.3732
Echinococcus granulosus flap endonuclease 1 0.0031 0.0409 0.0454
Onchocerca volvulus 0.006 0.1054 1
Brugia malayi hypothetical protein 0.0051 0.0844 0.0844
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0153 0.1356
Leishmania major cathepsin L-like protease 0.002 0.0153 0.0773
Brugia malayi MH2 domain containing protein 0.0123 0.2501 0.2501
Brugia malayi TAR-binding protein 0.0124 0.2523 0.2523
Schistosoma mansoni hypothetical protein 0.0023 0.0208 0.0309
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0409 0.4557
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0153 0.3732
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0153 0.3732
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0044 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1449 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Schistosoma mansoni hypothetical protein 0.0058 0.102 0.1514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0844 0.5697
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0409 0.2596
Loa Loa (eye worm) cysteine protease 0.002 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.006 0.1054 0.1054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0208 0.0232
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0409 0.5
Echinococcus granulosus tumor protein p63 0.0408 0.9 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.6206 0.688
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.2523 0.2523
Onchocerca volvulus 0.002 0.0153 0.1447
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Brugia malayi latrophilin 2 splice variant baaae 0.0309 0.6738 0.6738
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0409 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Leishmania major cysteine peptidase A (CPA) 0.002 0.0153 0.0773
Loa Loa (eye worm) hypothetical protein 0.002 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0286 0.6206 0.6206
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.2501 0.2501
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0153 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0153 0.3732
Loa Loa (eye worm) RNA binding protein 0.0124 0.2523 0.2523
Echinococcus multilocularis tumor protein p63 0.0408 0.9 1
Brugia malayi Latrophilin receptor protein 2 0.0143 0.2953 0.2953
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.2523 0.2523
Brugia malayi hypothetical protein 0.0033 0.0436 0.0436
Plasmodium falciparum flap endonuclease 1 0.0031 0.0409 0.4557
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1073 0.7322
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0409 0.2596
Brugia malayi Cathepsin L-like precursor 0.002 0.0153 0.0153
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1449 1
Leishmania major cathepsin L-like protease 0.002 0.0153 0.0773
Onchocerca volvulus 0.002 0.0153 0.1447
Brugia malayi Cathepsin L-like precursor 0.002 0.0153 0.0153
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0153 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2523 0.3744
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.2501 0.2501
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0044 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Echinococcus granulosus GPCR family 2 0.0143 0.2953 0.3281
Brugia malayi isocitrate dehydrogenase 0.0015 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1449 1
Schistosoma mansoni flap endonuclease-1 0.0028 0.034 0.0504
Onchocerca volvulus Cathepsin F homolog 0.002 0.0153 0.1447
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0153 0.3732
Brugia malayi Calcitonin receptor-like protein seb-1 0.0452 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0153 0.0153
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.102 0.102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0153 0.3732
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0058 0.102 0.968
Schistosoma mansoni hypothetical protein 0.0143 0.2953 0.4382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Schistosoma mansoni hypothetical protein 0.0143 0.2953 0.4382
Brugia malayi hypothetical protein 0.0286 0.6206 0.6206
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2523 0.3744
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0844 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0153 0.0169
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0143 0.2953 0.3248
Leishmania major cathepsin L-like protease 0.0077 0.1449 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0153 0.1356
Schistosoma mansoni hypothetical protein 0.0309 0.6738 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0409 0.4557
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0844 1
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0409 0.0407
Echinococcus multilocularis cysteine protease 0.002 0.0153 0.0121
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0208 0.0184
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0153 0.3732
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0153 0.3732
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0153 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2523 0.3744
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2523 0.3744
Loa Loa (eye worm) TAR-binding protein 0.0124 0.2523 0.2523
Toxoplasma gondii cathepsin CPL 0.002 0.0153 0.1356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Onchocerca volvulus 0.002 0.0153 0.1447
Loa Loa (eye worm) fibroinase 0.002 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0143 0.2953 0.4382
Plasmodium vivax vivapain-2 0.002 0.0153 0.1356
Onchocerca volvulus 0.002 0.0153 0.1447
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1449 1
Echinococcus multilocularis cysteine protease 0.002 0.0153 0.0121
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0153 0.1356
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0452 1 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0153 0.1447
Onchocerca volvulus 0.002 0.0153 0.1447
Brugia malayi RNA binding protein 0.0124 0.2523 0.2523
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0143 0.2953 0.3281
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0051 0.0844 0.0844
Echinococcus granulosus tar DNA binding protein 0.0124 0.2523 0.2803
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0153 0.0153
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0153 0.0121
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0044 0.0065
Echinococcus multilocularis tar DNA binding protein 0.0124 0.2523 0.2767
Onchocerca volvulus Cathepsin L homolog 0.002 0.0153 0.1447
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0153 0.0773
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0153 0.3732
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0153 0.0121
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0153 0.0226
Plasmodium vivax vivapain-2 0.002 0.0153 0.1356
Echinococcus granulosus cathepsin l1 0.002 0.0153 0.0169
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0844 0.5697
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1296 0.8914
Schistosoma mansoni cellular tumor antigen P53 0.006 0.1054 0.1564

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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