Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.3454 | 1 |
Onchocerca volvulus | 0.0182 | 1 | 0.5 | |
Brugia malayi | RNA binding protein | 0.0069 | 0.2658 | 0.1977 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.2658 | 0.6762 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0053 | 0.1638 | 0.4744 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0081 | 0.3454 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3454 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3454 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2658 | 0.6947 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0998 | 0.0162 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2658 | 0.6947 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.3454 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.2658 | 0.6762 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3454 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0998 | 0.057 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0053 | 0.1638 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2083 | 0.1348 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3454 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.2658 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0081 | 0.3454 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3454 | 0.2846 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.2658 | 0.1977 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2658 | 0.6947 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2658 | 0.6947 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2083 | 0.1348 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.3454 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0053 | 0.1638 | 0.2608 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3454 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0998 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0998 | 0.057 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3454 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0998 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2083 | 0.1348 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0998 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2658 | 0.6947 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0998 | 0.5 |
Brugia malayi | Probable ClpP-like protease | 0.0081 | 0.3454 | 0.2846 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.2658 | 0.1977 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2083 | 0.1348 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.2658 | 0.1977 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3454 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.2658 | 0.1977 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0053 | 0.1638 | 0.2608 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.3454 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0053 | 0.1638 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0081 | 0.3454 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.