Detailed information for compound 1456638

Basic information

Technical information
  • TDR Targets ID: 1456638
  • Name: N-[2-(2-methoxyphenoxy)ethyl]cyclopentanamine
  • MW: 235.322 | Formula: C14H21NO2
  • H donors: 1 H acceptors: 0 LogP: 2.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1OCCNC1CCCC1
  • InChi: 1S/C14H21NO2/c1-16-13-8-4-5-9-14(13)17-11-10-15-12-6-2-3-7-12/h4-5,8-9,12,15H,2-3,6-7,10-11H2,1H3
  • InChiKey: MDMGXNAXOWLMAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • cyclopentyl-[2-(2-methoxyphenoxy)ethyl]amine
  • MLS000537572
  • N-cyclopentyl-N-[2-(2-methoxyphenoxy)ethyl]amine
  • SMR000164023

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase eta 0.0043 0.2803 0.2804
Loa Loa (eye worm) hypothetical protein 0.0043 0.2803 0.2803
Schistosoma mansoni hypothetical protein 0.0033 0.1772 0.2319
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0761 0.076
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.3547 1
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.152 0.3665
Schistosoma mansoni intermediate filament proteins 0.0033 0.1748 0.2288
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.3293 0.3289
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0018 0.0233 0.0233
Echinococcus granulosus lamin 0.0033 0.1748 0.1746
Giardia lamblia PHD finger protein 15 0.0035 0.1995 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0761 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0761 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.1748 0.1748
Schistosoma mansoni hypothetical protein 0.0023 0.0756 0.0984
Echinococcus granulosus dna polymerase kappa 0.0019 0.0346 0.0341
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.2803 0.7676
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.3547 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0346 0.034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.7462 0.7474
Leishmania major DNA polymerase eta, putative 0.003 0.152 0.2153
Echinococcus granulosus lamin dm0 0.0033 0.1748 0.1746
Schistosoma mansoni DNA polymerase eta 0.0043 0.2803 0.3675
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.9981 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.7462 0.9794
Echinococcus granulosus peregrin 0.0035 0.1995 0.1994
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.3293 0.3289
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0761 0.0756
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.2733 0.2734
Plasmodium falciparum phd finger protein, putative 0.0035 0.1995 0.4429
Brugia malayi intermediate filament protein 0.0033 0.1748 0.1743
Echinococcus multilocularis musashi 0.0033 0.1748 0.1746
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0761 0.076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.7462 0.9794
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1748 0.1743
Plasmodium vivax hypothetical protein, conserved 0.0035 0.1995 0.4429
Loa Loa (eye worm) hypothetical protein 0.0035 0.1995 0.1995
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.337 0.3372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.7462 0.746
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0756 0.0751
Schistosoma mansoni lamin 0.0033 0.1748 0.2288
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0346 0.0341
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.5795 1
Leishmania major DNA polymerase eta, putative 0.0043 0.2803 0.4509
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0346 0.0447
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.2803 0.7676
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.5732 0.5732
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.5795 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1748 0.1748
Schistosoma mansoni lamin 0.0033 0.1748 0.2288
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.5795 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0756 0.0751
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.7462 0.7474
Schistosoma mansoni hypothetical protein 0.0035 0.1995 0.2613
Echinococcus granulosus dna polymerase eta 0.0043 0.2803 0.2804
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.2733 0.2734
Echinococcus granulosus intermediate filament protein 0.0033 0.1748 0.1746
Brugia malayi jmjC domain containing protein 0.0115 0.9981 0.9981
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.1995 0.1995
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.7462 0.7462
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.5795 0.5804
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.2733 0.3583
Brugia malayi hypothetical protein 0.0051 0.3547 0.3543
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.5795 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 1 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0761 0.076
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0346 0.0447
Schistosoma mansoni ap endonuclease 0.0023 0.0761 0.0991
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0346 0.0341
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.2733 0.3583
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0761 0.1294
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.5795 1
Echinococcus granulosus jumonji domain containing protein 0.0049 0.337 0.3372
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.3547 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0006 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0761 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0346 0.0346
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.1995 0.2452
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.1995 0.1994
Echinococcus multilocularis peregrin 0.0035 0.1995 0.1994
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0761 0.1294
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0761 0.0756
Leishmania major hypothetical protein, conserved 0.0051 0.3547 0.5875
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0761 0.0755
Loa Loa (eye worm) hypothetical protein 0.006 0.4503 0.4503
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0761 1
Echinococcus multilocularis lamin dm0 0.0033 0.1748 0.1746
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.1995 0.2452
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.9981 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Brugia malayi PHD-finger family protein 0.0035 0.1995 0.199
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.1995 0.2613
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.2733 0.2733
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.152 0.1508
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0761 0.1294
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.5795 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.3293 0.3293
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0346 0.0341
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.006 0.0054
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.006 0.0054
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.3547 0.5535
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1772 0.1767
Onchocerca volvulus Alhambra homolog 0.0035 0.1995 1
Brugia malayi hypothetical protein 0.0033 0.1753 0.1748
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.006
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.1995 0.1994
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1748 0.1748
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0761 0.0761
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.7462 0.9794
Brugia malayi cytoplasmic intermediate filament protein 0.0018 0.0233 0.0227
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.3547 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.3293 0.3293
Loa Loa (eye worm) transcription factor SMAD2 0.0115 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.3547 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.5795 0.5804
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.3547 1
Schistosoma mansoni ap endonuclease 0.0023 0.0761 0.0991
Loa Loa (eye worm) hypothetical protein 0.0032 0.1688 0.1688
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0761 0.2513
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.2803 0.2799
Brugia malayi jmjC domain containing protein 0.0043 0.2733 0.2729
Schistosoma mansoni jumonji domain containing protein 0.0092 0.7618 1
Brugia malayi Bromodomain containing protein 0.0035 0.1995 0.199
Echinococcus multilocularis lamin 0.0033 0.1748 0.1746
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.7462 0.7474
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.7462 0.7474
Loa Loa (eye worm) hypothetical protein 0.0051 0.3547 0.3547
Loa Loa (eye worm) hypothetical protein 0.0033 0.1772 0.1772
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0761 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.5795 0.7605
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.5795 0.7605

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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