Detailed information for compound 1456733

Basic information

Technical information
  • TDR Targets ID: 1456733
  • Name: [2-(2-methoxyethyl)piperidin-1-yl]-[5-[(6-met hylpyridin-3-yl)oxymethyl]-1,2-oxazol-3-yl]me thanone
  • MW: 359.42 | Formula: C19H25N3O4
  • H donors: 0 H acceptors: 3 LogP: 2.11 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCC1CCCCN1C(=O)c1noc(c1)COc1ccc(nc1)C
  • InChi: 1S/C19H25N3O4/c1-14-6-7-16(12-20-14)25-13-17-11-18(21-26-17)19(23)22-9-4-3-5-15(22)8-10-24-2/h6-7,11-12,15H,3-5,8-10,13H2,1-2H3
  • InChiKey: JUHGLYPSDFAUKP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-(2-methoxyethyl)-1-piperidyl]-[5-[(6-methyl-3-pyridyl)oxymethyl]isoxazol-3-yl]methanone
  • [2-(2-methoxyethyl)-1-piperidinyl]-[5-[(6-methyl-3-pyridyl)oxymethyl]-3-isoxazolyl]methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0003 0.0003
Echinococcus multilocularis beta adrenergic receptor kinase 0.0062 0.0086 0.0084
Brugia malayi 6-phosphofructokinase 0.0231 0.0448 0.0547
Chlamydia trachomatis glutamine binding protein 0.0344 0.0689 0.2703
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0231 0.319
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0019 0.0016
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0231 0.0448 0.1731
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0047 0.0045
Onchocerca volvulus 0.0022 0.0003 0.0001
Echinococcus multilocularis neutral amino acid transporter A 0.1195 0.2504 0.2503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Loa Loa (eye worm) hypothetical protein 0.0487 0.0995 0.0993
Leishmania major cathepsin L-like protease 0.0063 0.0089 0.0838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0036 0.0182
Trichomonas vaginalis glutaminase, putative 0.027 0.0531 0.325
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0098 0.0165 0.0162
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0042 0.0355
Schistosoma mansoni axis inhibition protein axin 0.0062 0.0086 0.0093
Brugia malayi Metabotropic glutamate receptor precursor. 0.3849 0.817 1
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0448 0.2733
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.4219 0.896 1
Schistosoma mansoni tyrosine kinase 0.0487 0.0995 0.1108
Echinococcus granulosus glutamate receptor 2 0.1067 0.2233 0.2231
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0156 0.0154
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0602 0.124 0.1517
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0085 0.0488
Brugia malayi Doublecortin family protein 0.0022 0.0003 0.0003
Echinococcus granulosus excitatory amino acid transporter 3 0.1195 0.2504 0.2503
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0003 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0017 0.0106
Schistosoma mansoni hypothetical protein 0.036 0.0723 0.0804
Schistosoma mansoni glutaminase 0.027 0.0531 0.059
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0061 0.0085 0.0274
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0003 0.0003
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0062 0.0086 0.0093
Schistosoma mansoni regulator of G protein signaling 0.0062 0.0086 0.0093
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0043
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0016 0.0014
Brugia malayi Glutamate receptor 1 precursor 0.058 0.1193 0.146
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.0085 0.1015
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0047 0.0045
Echinococcus multilocularis lamin dm0 0.0062 0.0088 0.0085
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0016 0.0015
Toxoplasma gondii exonuclease III APE 0.0061 0.0085 0.3204
Brugia malayi Glutamate receptor 2 precursor 0.058 0.1193 0.146
Loa Loa (eye worm) hypothetical protein 0.0602 0.124 0.1238
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0088 0.0085
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1195 0.2504 0.2503
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0115 0.0125
Entamoeba histolytica hypothetical protein 0.0043 0.0047 0.0415
Onchocerca volvulus 0.0062 0.0088 0.034
Loa Loa (eye worm) hypothetical protein 0.0487 0.0995 0.0993
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0448 0.2733
Loa Loa (eye worm) hypothetical protein 0.0062 0.0086 0.0084
Brugia malayi glutathione reductase 0.0084 0.0134 0.0164
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.0085 0.9618
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0064 0.058
Mycobacterium tuberculosis Probable dehydrogenase 0.0192 0.0364 0.1396
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0017 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Brugia malayi metabotropic glutamate receptor type 2 0.1947 0.411 0.5031
Echinococcus granulosus tyrosine kinase 0.0487 0.0995 0.0993
Loa Loa (eye worm) phosphofructokinase 0.0231 0.0448 0.0445
Echinococcus multilocularis tyrosine kinase 0.0487 0.0995 0.0993
Schistosoma mansoni hypothetical protein 0.027 0.0531 0.059
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0115 0.1097
Schistosoma mansoni lipoxygenase 0.0063 0.0089 0.0096
Brugia malayi hypothetical protein 0.0438 0.0889 0.1087
Entamoeba histolytica hypothetical protein 0.0043 0.0047 0.0415
Schistosoma mansoni protein kinase 0.0487 0.0995 0.1108
Echinococcus granulosus excitatory amino acid transporter 2 0.1195 0.2504 0.2503
Leishmania major cathepsin L-like protease 0.0063 0.0089 0.0838
Echinococcus granulosus glutamate receptor 1 0.0043 0.0045 0.0043
Loa Loa (eye worm) glutaminase 0.027 0.0531 0.0529
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0017 0.1091
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0089 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0028 0.0133
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1195 0.2504 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0064 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0086 0.0494
Onchocerca volvulus 0.0438 0.0889 0.3542
Brugia malayi steroid hormone receptor 0.0022 0.0003 0.0003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0062 0.0088 0.6482
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0064 0.0061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0017 0.0106
Brugia malayi ecdysteroid receptor 0.0022 0.0003 0.0003
Brugia malayi nuclear receptor NHR-88 0.0022 0.0003 0.0003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0017 0.0886
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0017 0.0106
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0017 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0064 0.0355
Echinococcus multilocularis glutamate receptor 2 0.0797 0.1656 0.1654
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0098 0.0165 0.0162
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0064 0.058
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0231 0.0255
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1353 0.2842 0.284
Brugia malayi Pre-SET motif family protein 0.0686 0.1419 0.1736
Brugia malayi hypothetical protein 0.0022 0.0003 0.0003
Schistosoma mansoni glutamate receptor AMPA 0.0538 0.1102 0.1228
Leishmania major ATP-dependent phosphofructokinase 0.0231 0.0448 0.4463
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.0231 0.0229
Loa Loa (eye worm) hypothetical protein 0.0487 0.0995 0.0993
Trypanosoma cruzi extracellular receptor, putative 0.0487 0.0995 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.0538 0.1102 0.11
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0085 0.6273
Treponema pallidum glutamate/aspartate transporter 0.0529 0.1085 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0017 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0083
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0062 0.0086 0.0494
Echinococcus multilocularis lamin 0.0062 0.0088 0.0085
Brugia malayi Bromodomain containing protein 0.0029 0.0016 0.0019
Echinococcus granulosus histone lysine methyltransferase setb 0.0098 0.0165 0.0162
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0064 0.1424
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0089 0.0838
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0344 0.0689 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0064 0.058
Leishmania major extracellular receptor, putative 0.0487 0.0995 1
Brugia malayi PXA domain containing protein 0.0062 0.0086 0.0105
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0062 0.0086 0.0084
Toxoplasma gondii thioredoxin reductase 0.0084 0.0134 0.5484
Loa Loa (eye worm) PXA domain-containing protein 0.0062 0.0086 0.0084
Loa Loa (eye worm) cytochrome P450 family protein 0.0079 0.0124 0.0121
Chlamydia trachomatis neutral amino acid transporter 0.0529 0.1085 0.4293
Schistosoma mansoni hypothetical protein 0.036 0.0723 0.0804
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.0085 0.0796
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0048 0.0256
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0344 0.0689 0.6295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0036 0.0182
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0017 0.0106
Echinococcus multilocularis axis inhibition protein axin 0.0062 0.0086 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Entamoeba histolytica hypothetical protein 0.0062 0.0086 0.0808
Loa Loa (eye worm) hypothetical protein 0.0098 0.0165 0.0162
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0115 0.0112
Brugia malayi hypothetical protein 0.0119 0.0208 0.0254
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0014
Brugia malayi phosphofructokinase 0.0231 0.0448 0.0547
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0051 0.0063
Plasmodium falciparum glutathione reductase 0.0084 0.0134 1
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1195 0.2504 1
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0088 0.0505
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2045 0.2043
Echinococcus multilocularis NMDA receptor 0.0598 0.1231 0.1229
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0029 0.0027
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0062 0.0086 0.0084
Brugia malayi intermediate filament protein 0.0062 0.0088 0.0107
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0064 0.058
Echinococcus multilocularis peregrin 0.0029 0.0016 0.0014
Plasmodium vivax glutathione reductase, putative 0.0084 0.0134 0.812
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0025 0.0118
Echinococcus multilocularis axis inhibition protein axin 0.0062 0.0086 0.0084
Brugia malayi hypothetical protein 0.0022 0.0003 0.0003
Echinococcus multilocularis Regulator of G protein signaling 20 0.0062 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0043
Schistosoma mansoni glutamate receptor AMPA 0.0538 0.1102 0.1228
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0086 0.0494
Loa Loa (eye worm) hypothetical protein 0.0487 0.0995 0.0993
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0003 0.0001
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0115 0.014
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0064 0.0068
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0686 0.1419 0.1416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0049 0.006 0.0058
Loa Loa (eye worm) hypothetical protein 0.4706 1 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0529 0.1085 0.1083
Schistosoma mansoni ATP-binding cassette transporter 0.0538 0.1102 0.1228
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0598 0.1231 0.1229
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0062 0.0088 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Loa Loa (eye worm) hypothetical protein 0.0487 0.0995 0.0993
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.027 0.0531 0.0529
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0062 0.0088 0.0505
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.0231 0.0862
Brugia malayi PHD-finger family protein 0.0029 0.0016 0.0019
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0026 0.0031
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0089 0.0838
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0115 0.1097
Toxoplasma gondii 6-phosphofructokinase 0.0062 0.0088 0.3332
Brugia malayi Excitatory amino acid transporter 0.1195 0.2504 0.3065
Entamoeba histolytica hypothetical protein 0.0043 0.0047 0.0415
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0036 0.0911
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0064 0.0061
Brugia malayi hypothetical protein 0.0487 0.0995 0.1217
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.1067 0.2233 0.2231
Onchocerca volvulus Poor gastrulation protein homolog 0.0602 0.124 0.4946
Schistosoma mansoni regulator of G protein signaling 0.0062 0.0086 0.0093
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.109 0.228 0.2278
Echinococcus granulosus Regulator of G protein signaling 20 0.0062 0.0086 0.0084
Onchocerca volvulus 0.0781 0.1621 0.6469
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0017 0.0378
Leishmania major trypanothione reductase 0.0084 0.0134 0.1293
Echinococcus multilocularis geminin 0.036 0.0723 0.0721
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0134 0.0472
Echinococcus multilocularis regulator of G protein signaling 3 0.0062 0.0086 0.0084
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1195 0.2504 0.2503
Echinococcus granulosus glutamate receptor 4 0.0043 0.0045 0.0043
Entamoeba histolytica hypothetical protein 0.0043 0.0047 0.0415
Loa Loa (eye worm) hypothetical protein 0.0119 0.0208 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0013 0.0044
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0017 0.0378
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.0085 0.0639
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0088 0.0505
Mycobacterium tuberculosis Probable oxidoreductase 0.0213 0.041 0.158
Brugia malayi jmjC domain containing protein 0.0094 0.0156 0.0191
Echinococcus granulosus peregrin 0.0029 0.0016 0.0014
Treponema pallidum glutamate transporter 0.0529 0.1085 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.3362 0.713 0.8727
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0098 0.0165 0.6901
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0086 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0083
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1353 0.2842 0.284
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0016 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0017 0.0106
Echinococcus granulosus geminin 0.036 0.0723 0.0721
Loa Loa (eye worm) hypothetical protein 0.0062 0.0086 0.0084
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0538 0.1102 0.11
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0134 0.1293
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0003 0.0003
Onchocerca volvulus 0.0487 0.0995 0.3967
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.0085 0.0274
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0487 0.0995 0.3967
Echinococcus granulosus axis inhibition protein axin 0.0062 0.0086 0.0084
Echinococcus granulosus thioredoxin glutathione reductase 0.0085 0.0135 0.0133
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0062 0.0086 0.0105
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0064 0.058
Schistosoma mansoni regulator of G protein signaling 0.0062 0.0086 0.0093
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0014
Echinococcus granulosus excitatory amino acid transporter 2 0.1195 0.2504 0.2503
Echinococcus granulosus nmda type glutamate receptor 0.0614 0.1266 0.1264
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0156 0.0154
Schistosoma mansoni regulator of G protein signaling 0.0062 0.0086 0.0093
Echinococcus granulosus beta-adrenergic receptor kinase 0.0062 0.0086 0.0084
Echinococcus granulosus 6 phosphofructokinase 0.0231 0.0448 0.0445
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0095 0.0157 0.0154
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0231 0.0448 1
Entamoeba histolytica phosphofructokinase, putative 0.0231 0.0448 0.4463
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0192 0.0364 0.1396
Echinococcus granulosus neutral amino acid transporter 0.1195 0.2504 0.2503
Loa Loa (eye worm) hypothetical protein 0.0487 0.0995 0.0993
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0062 0.0086 0.0084
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0062 0.0088 0.0285
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0078 0.072
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0529 0.1085 0.1208
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.0085 0.0083
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0014
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0105 0.0179 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0088 0.0505
Echinococcus multilocularis expressed protein 0.12 0.2516 0.2514
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0371 0.0748 0.0745
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.0085 0.0104
Echinococcus granulosus lamin dm0 0.0062 0.0088 0.0085
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0051 0.0279
Schistosoma mansoni intermediate filament proteins 0.0062 0.0088 0.0095
Loa Loa (eye worm) RecQ helicase 0.0045 0.0051 0.0049
Brugia malayi Pre-SET motif family protein 0.0098 0.0165 0.0201
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0062 0.0086 0.0084
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0213 0.041 0.5473
Loa Loa (eye worm) hypothetical protein 0.0061 0.0085 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0112 0.0193 0.0213
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0017 0.0106
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.0085 0.0796
Echinococcus granulosus receptor type guanylyl cyclase 0.0487 0.0995 0.0993
Mycobacterium tuberculosis Probable reductase 0.0192 0.0364 0.1396
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0231 0.0448 0.4463
Schistosoma mansoni lozenge 0.0055 0.0072 0.0077
Echinococcus granulosus glutamate receptor subunit protein glur 0.0313 0.0622 0.062
Echinococcus granulosus atrial natriuretic peptide receptor 0.0487 0.0995 0.0993
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0047 0.005
Onchocerca volvulus 0.0487 0.0995 0.3967
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0487 0.0995 0.0993
Loa Loa (eye worm) hypothetical protein 0.0062 0.0088 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0041 0.0217
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0006 0.0143
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0031 0.0032
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0231 0.0448 0.4033
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0047 0.0045
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0105 0.0179 0.0177
Schistosoma mansoni lamin 0.0062 0.0088 0.0095
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0062 0.0088 0.3332
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0017 0.0106
Plasmodium falciparum thioredoxin reductase 0.0029 0.0017 0.1091
Echinococcus granulosus Excitatory amino acid transporter 0.1195 0.2504 0.2503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0064 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0041 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0044
Echinococcus granulosus GPCR family 3 C terminal 0.0602 0.124 0.1238
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0003 0.0003
Leishmania major cathepsin L-like protease 0.0063 0.0089 0.0838
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0041 0.0217
Echinococcus granulosus lamin 0.0062 0.0088 0.0085
Schistosoma mansoni lamin 0.0062 0.0088 0.0095
Schistosoma mansoni z-protein (S1r protein) 0.0062 0.0086 0.0093
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0017 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0165 0.0181
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0051 0.0049
Echinococcus granulosus sodium:dicarboxylate symporter 0.1195 0.2504 0.2503
Schistosoma mansoni 6-phosphofructokinase 0.0231 0.0448 0.0497
Schistosoma mansoni 6-phosphofructokinase 0.0231 0.0448 0.0497
Loa Loa (eye worm) hypothetical protein 0.0062 0.0086 0.0084
Brugia malayi hypothetical protein 0.0143 0.0259 0.0316
Mycobacterium ulcerans 6-phosphofructokinase 0.0231 0.0448 0.6407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0083
Schistosoma mansoni tyrosine kinase 0.0487 0.0995 0.1108
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0017 0.0033
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0064 0.1424
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0042 0.0355
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0089 0.0838
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0006 0.014
Giardia lamblia GTOR 0.0051 0.0064 0.6631
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Echinococcus granulosus jumonji domain containing protein 0.004 0.004 0.0038
Echinococcus multilocularis metabotropic glutamate receptor 5 0.4706 1 1
Schistosoma mansoni hypothetical protein 0.0043 0.0047 0.005
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.006 0.0547
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0448 0.2733
Entamoeba histolytica hypothetical protein 0.0062 0.0086 0.0808
Echinococcus multilocularis Protein lozenge 0.0055 0.0072 0.0069
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0105 0.0179 0.0177
Brugia malayi Receptor family ligand binding region containing protein 0.109 0.228 0.2791
Brugia malayi Thioredoxin reductase 0.0084 0.0134 0.0164
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0003 0.0003
Brugia malayi A-kinase anchor protein 10, precursor 0.0062 0.0086 0.0105
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.027 0.0531 0.0529
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0165 0.0181
Brugia malayi Cytochrome P450 family protein 0.0079 0.0124 0.0151
Entamoeba histolytica hypothetical protein 0.0062 0.0086 0.0808
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0017 0.0378
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0026 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Echinococcus granulosus nmda type glutamate receptor 0.0487 0.0995 0.0993
Loa Loa (eye worm) hypothetical protein 0.0062 0.0086 0.0084
Brugia malayi Regulator of G protein signaling domain containing protein 0.0062 0.0086 0.0105
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0017 0.0065
Loa Loa (eye worm) hypothetical protein 0.0438 0.0889 0.0886
Loa Loa (eye worm) hypothetical protein 0.0062 0.0086 0.0084
Schistosoma mansoni ap endonuclease 0.0061 0.0085 0.0092
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0313 0.0622 0.062
Schistosoma mansoni axis inhibition protein axin 0.0062 0.0086 0.0093
Plasmodium vivax SET domain protein, putative 0.0098 0.0165 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0213 0.041 0.158
Plasmodium falciparum phd finger protein, putative 0.0029 0.0016 0.1037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0213 0.041 0.158
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0192 0.0364 0.1396
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0003 0.0003
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0134 0.0132
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0598 0.1231 0.1229
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0082 0.0079
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0231 0.0448 1
Echinococcus multilocularis 6 phosphofructokinase 0.0231 0.0448 0.0445
Echinococcus multilocularis nmda type glutamate receptor 0.0487 0.0995 0.0993
Echinococcus multilocularis regulator of G protein signaling 0.0062 0.0086 0.0084
Loa Loa (eye worm) 6-phosphofructokinase 0.0231 0.0448 0.0445
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0017 0.0106
Brugia malayi regulator of G-protein signaling egl-10 0.0062 0.0086 0.0105
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.0085 0.1902
Onchocerca volvulus 0.0119 0.0208 0.0821
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0003 0.0001
Schistosoma mansoni regulator of G protein signaling 0.0062 0.0086 0.0093
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0942 0.1965 0.1963
Plasmodium vivax 6-phosphofructokinase, putative 0.0062 0.0088 0.5263
Loa Loa (eye worm) hypothetical protein 0.0487 0.0995 0.0993
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0115 0.0112
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.0085 0.0083
Mycobacterium ulcerans glutaminase 0.027 0.0531 0.765
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0086 0.0093
Echinococcus multilocularis Excitatory amino acid transporter 0.1195 0.2504 0.2503
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0003 0.0003
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0088 0.0085
Brugia malayi PXA domain containing protein 0.0062 0.0086 0.0105
Brugia malayi Guanylyl cyclase protein 23 0.0487 0.0995 0.1217
Echinococcus multilocularis receptor type guanylyl cyclase 0.0487 0.0995 0.0993
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0086 0.0093
Loa Loa (eye worm) RGS-3 protein 0.0062 0.0086 0.0084
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0344 0.0689 0.2703
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0088 0.0505
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0051 0.0279
Plasmodium falciparum glutathione reductase 0.0029 0.0017 0.1091
Loa Loa (eye worm) hypothetical protein 0.0438 0.0889 0.0886
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0017 0.0378
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Brugia malayi hypothetical protein 0.0062 0.0086 0.0105
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.0085 0.0796
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.109 0.228 0.2278
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0062 0.0088 0.0285
Echinococcus multilocularis glutamate receptor 2 0.1067 0.2233 0.2231
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0134 0.812
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0598 0.1231 0.1229
Echinococcus granulosus Excitatory amino acid transporter 0.1195 0.2504 0.2503
Echinococcus granulosus neutral amino acid transporter A 0.1195 0.2504 0.2503
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0115 0.2566
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0086 0.0494
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1353 0.2842 0.284
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0088 0.0505
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0487 0.0995 0.0993
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0192 0.0364 0.1396
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.0231 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.109 0.228 0.2278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0044
Chlamydia trachomatis glutamate symporter 0.1195 0.2504 1
Brugia malayi glutaminase DH11.1 0.027 0.0531 0.065
Schistosoma mansoni glutamate receptor kainate 0.0538 0.1102 0.1228
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0017 0.0014
Schistosoma mansoni glutamate receptor kainate 0.0865 0.1801 0.2008
Loa Loa (eye worm) glutathione reductase 0.0084 0.0134 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0013 0.0044
Brugia malayi hypothetical protein 0.0043 0.0047 0.0058
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0115 0.0125
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0064 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0086 0.0494
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0003 0.0001
Loa Loa (eye worm) glutamate receptor 0.3849 0.817 0.8169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0036 0.0182
Loa Loa (eye worm) glutaminase 2 0.027 0.0531 0.0529
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0088 0.0107
Echinococcus multilocularis excitatory amino acid transporter 3 0.1195 0.2504 0.2503
Schistosoma mansoni glutamate receptor NMDA 0.0538 0.1102 0.1228
Echinococcus granulosus neutral amino acid transporter A 0.1195 0.2504 0.2503
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0003 0.0003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1353 0.2842 0.284
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.004 0.2824
Echinococcus granulosus regulator of G protein signaling 7 0.0062 0.0086 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0019 0.0079
Echinococcus multilocularis musashi 0.0062 0.0088 0.0085
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0017 0.1091
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0016 0.0014
Echinococcus granulosus regulator of G protein signaling 3 0.0062 0.0086 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0041 0.0217
Loa Loa (eye worm) excitatory amino acid transporter 0.1195 0.2504 0.2503
Echinococcus multilocularis jumonji domain containing protein 0.004 0.004 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0036 0.0182
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0192 0.0364 0.1396
Loa Loa (eye worm) runx1 0.0055 0.0072 0.0069
Brugia malayi Receptor family ligand binding region containing protein 0.0487 0.0995 0.1217
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1353 0.2842 0.284
Brugia malayi 6-phosphofructokinase 0.0231 0.0448 0.0547
Loa Loa (eye worm) RGC/RGC protein kinase 0.0487 0.0995 0.0993
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0115 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0036 0.0182
Echinococcus multilocularis metabotropic glutamate receptor 2 0.3247 0.6885 0.6884
Echinococcus multilocularis glutamate receptor 4 0.0043 0.0045 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0016 0.0842
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0062 0.0088 0.0824
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0017 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0086 0.0494
Echinococcus granulosus bloom syndrome protein 0.0045 0.0051 0.0049
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0344 0.0689 0.6295
Brugia malayi hypothetical protein 0.0062 0.0086 0.0105
Brugia malayi regulator of G-protein signaling rgs-7 0.0062 0.0086 0.0105
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.0085 0.0796
Schistosoma mansoni hypothetical protein 0.0602 0.124 0.1382
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0017 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0003 0.0003
Echinococcus multilocularis regulator of G protein signaling 7 0.0062 0.0086 0.0084
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0017 0.01
Entamoeba histolytica phosphofructokinase, putative 0.0231 0.0448 0.4463
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0062 0.0088 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0013 0.0044
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1195 0.2504 1
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1195 0.2504 0.2793
Loa Loa (eye worm) glutamate receptor 2 0.0538 0.1102 0.11
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0062 0.0086 0.0093
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0019 0.0016
Schistosoma mansoni ap endonuclease 0.0061 0.0085 0.0092
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0115 0.1097
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.0029
Onchocerca volvulus Alhambra homolog 0.0029 0.0016 0.0055
Brugia malayi Regulator of G protein signaling domain containing protein 0.0062 0.0086 0.0105
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0231 0.319
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0017 0.0886
Entamoeba histolytica hypothetical protein 0.0487 0.0995 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0454 0.0452
Onchocerca volvulus 0.0119 0.0208 0.0821
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0047 0.0045
Echinococcus granulosus metabotropic glutamate receptor 2 0.3247 0.6885 0.6884
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.0231 0.0229
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0089 0.0086
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0231 0.319
Brugia malayi jmjC domain containing protein 0.0035 0.0029 0.0035
Schistosoma mansoni metabotropic glutamate receptor 0.3247 0.6885 0.7683
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0003 0.0003
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0017 0.0065
Echinococcus granulosus expressed protein 0.12 0.2516 0.2514
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0085 0.5094
Loa Loa (eye worm) RGC/RGC protein kinase 0.0487 0.0995 0.0993
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0029 0.003
Entamoeba histolytica phosphofructokinase, putative 0.0231 0.0448 0.4463
Echinococcus granulosus glutamate receptor 2 0.0797 0.1656 0.1654
Echinococcus granulosus axis inhibition protein axin 0.0062 0.0086 0.0084
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.1067 0.2233 0.2231
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.002 0.1085
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0062 0.0086 0.0084
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0062 0.0088 0.6482
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0454 0.0555
Loa Loa (eye worm) glutamate receptor 1 0.058 0.1193 0.1191
Echinococcus multilocularis neutral amino acid transporter A 0.1195 0.2504 0.2503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0017 0.0106
Schistosoma mansoni glutamate receptor NMDA 0.1025 0.2142 0.2389
Schistosoma mansoni metabotropic glutamate receptor 0.1947 0.411 0.4586
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0602 0.124 0.4946
Loa Loa (eye worm) 6-phosphofructokinase 0.0231 0.0448 0.0445
Echinococcus multilocularis Excitatory amino acid transporter 0.1195 0.2504 0.2503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0089 0.1994
Echinococcus multilocularis excitatory amino acid transporter 2 0.1195 0.2504 0.2503
Echinococcus multilocularis nmda type glutamate receptor 0.0614 0.1266 0.1264
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.0085 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0003 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) RGC/RGC protein kinase 0.0487 0.0995 0.0993
Brugia malayi nuclear hormone receptor 0.0022 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0165 0.0181
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0019 0.0147
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0088 0.0505
Plasmodium vivax 6-phosphofructokinase, putative 0.0062 0.0088 0.5263
Plasmodium falciparum thioredoxin reductase 0.0084 0.0134 1
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0231 0.0255
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0029 0.0027
Echinococcus multilocularis glutamate receptor 2 0.058 0.1193 0.1191
Echinococcus multilocularis regulator of G protein signaling 3 0.0062 0.0086 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0086 0.0494
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0016
Schistosoma mansoni glutamate receptor kainate 0.0865 0.1801 0.2008
Trichomonas vaginalis phosphofructokinase, putative 0.0231 0.0448 0.2733
Echinococcus multilocularis thioredoxin glutathione reductase 0.0085 0.0135 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0036 0.0182
Echinococcus granulosus regulator of G protein signaling 7 0.0062 0.0086 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0019 0.0079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0029 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0041 0.0217
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0064 0.0061
Loa Loa (eye worm) hypothetical protein 0.0119 0.0208 0.0205
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1353 0.2842 0.284
Brugia malayi M-phase phosphoprotein, mpp8 0.0119 0.0208 0.0254
Echinococcus multilocularis excitatory amino acid transporter 2 0.1195 0.2504 0.2503
Toxoplasma gondii phosphofructokinase PFKII 0.0062 0.0088 0.3332
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0089 0.0838
Echinococcus multilocularis neutral amino acid transporter A 0.1195 0.2504 0.2503
Echinococcus multilocularis GPCR, family 3, C terminal 0.0602 0.124 0.1238
Trypanosoma brucei trypanothione reductase 0.0084 0.0134 0.2998
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0344 0.0689 0.2703
Echinococcus granulosus regulator of G protein signaling 3 0.0062 0.0086 0.0084
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0115 0.0112
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0029 0.0027
Onchocerca volvulus 0.0112 0.0193 0.0762
Trichomonas vaginalis set domain proteins, putative 0.0781 0.1621 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0036 0.0182
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0017 0.0016
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0487 0.0995 0.1217
Echinococcus granulosus intermediate filament protein 0.0062 0.0088 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0064 0.0355
Loa Loa (eye worm) hypothetical protein 0.0062 0.0086 0.0084
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0017 0.0106
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0529 0.1085 0.1208
Echinococcus multilocularis regulator of G protein signaling 7 0.0062 0.0086 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0029 0.0016 0.0015
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.0231 0.2276
Loa Loa (eye worm) glutamate receptor 0.146 0.307 0.3068
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0085 0.0488
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0105 0.0179 0.0197
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0062 0.0086 0.0093
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0042 0.0928
Onchocerca volvulus 0.0062 0.0088 0.034
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0529 0.1085 0.1083

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.6834 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.