Detailed information for compound 145674

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.38 | Formula: C18H14N2O4S
  • H donors: 1 H acceptors: 3 LogP: 3.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C(S1)Cc1ccc(cc1)OCc1nc2c(o1)cccc2
  • InChi: 1S/C18H14N2O4S/c21-17-15(25-18(22)20-17)9-11-5-7-12(8-6-11)23-10-16-19-13-3-1-2-4-14(13)24-16/h1-8,15H,9-10H2,(H,20,21,22)
  • InChiKey: SQWNJVRCRCZMOH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0913 0.3856
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.023 0.097
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0014 0.023 0.3395
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Entamoeba histolytica hypothetical protein 0.0038 0.1244 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0677 1
Brugia malayi nuclear hormone receptor 0.0014 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0913 0.1643
Schistosoma mansoni smad 0.0016 0.0327 0.0589
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0913 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0327 0.1382
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.005 0.0742
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.023 0.1061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0913 0.3856
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0303 0.128
Brugia malayi conserved hypotetical protein 0.0014 0.023 0.023
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0014 0.023 0.3395
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0913 0.0913
Schistosoma mansoni hypothetical protein 0.0064 0.2368 0.4261
Loa Loa (eye worm) transcription factor SMAD2 0.0242 1 1
Brugia malayi ecdysone receptor 0.0014 0.023 0.023
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0662 0.0662
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.005 0.005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0913 0.3856
Loa Loa (eye worm) hypothetical protein 0.0016 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0913 0.0913
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0303 0.0546
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.023 0.023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.023 0.0971
Schistosoma mansoni nuclear hormone receptor 0.003 0.0913 0.1643
Schistosoma mansoni hypothetical protein 0.0064 0.2368 0.4261
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0303 0.128
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0177 0.2611
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.023 0.023
Brugia malayi Nuclear hormone receptor E75 0.0014 0.023 0.023
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0327 0.1382
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.023 0.023
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.005 0.0212
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0177 0.2669
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0662 0.2796
Loa Loa (eye worm) RecQ helicase 0.0024 0.0662 0.0662
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.023 0.3395
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0913 0.3856
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.2368 1
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0913 0.3856
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0913 0.1643
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.023 0.2519
Loa Loa (eye worm) hypothetical protein 0.003 0.0913 0.0913
Brugia malayi Smad1 0.0016 0.0327 0.0327
Schistosoma mansoni nuclear hormone receptor 0.0014 0.023 0.0414
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.023 0.0971
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.2368 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.003 0.0913 0.0913
Loa Loa (eye worm) hypothetical protein 0.0016 0.0303 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0913 0.0913
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0009 0 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0913 0.0913
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0913 0.1643
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0913 0.3856
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.1244 0.2238
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0913 1
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0913 0.0913
Brugia malayi MH1 domain containing protein 0.0009 0.0011 0.0011
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.005 0.0742
Onchocerca volvulus 0.0014 0.023 0.2519
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0913 0.0913
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.005 0.0212
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0913 0.1643
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Echinococcus granulosus GPCR family 2 0.0064 0.2368 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0913 0.3856
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0913 0.0913
Schistosoma mansoni hypothetical protein 0.0138 0.5558 1
Brugia malayi isocitrate dehydrogenase 0.0014 0.023 0.023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.1244 0.5251
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0014 0.023 0.3395
Leishmania major hypothetical protein, conserved 0.0025 0.0677 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0913 0.3856
Schistosoma mansoni DNA helicase recq5 0.001 0.005 0.009
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.005 0.0212
Brugia malayi Nuclear hormone receptor E75 0.0014 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0303 0.0303
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.8306 0.8306
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0325 0.4796
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0009 0 0.5
Schistosoma mansoni DNA helicase recq1 0.001 0.005 0.009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0094 0.0397
Brugia malayi MH1 domain containing protein 0.0016 0.0327 0.0327
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0913 0.0913
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0913 0.1643
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.023 0.0971
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0913 0.3856
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0536 0.7912
Brugia malayi nuclear receptor NHR-88 0.003 0.0913 0.0913
Brugia malayi MH1 domain containing protein 0.0009 0.0011 0.0011
Brugia malayi MH1 domain containing protein 0.0016 0.0327 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0913 0.0913
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0913 0.3856
Schistosoma mansoni hypothetical protein 0.0038 0.1244 0.2238
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.023 0.3395
Brugia malayi hypothetical protein 0.0016 0.0303 0.0303
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0913 0.0913
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.023 0.023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0913 0.3856
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.005 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0913 0.0913
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.023 0.0971
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0009 0 0.5
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.023 0.023
Schistosoma mansoni thyroid hormone receptor 0.003 0.0913 0.1643
Brugia malayi hypothetical protein 0.0025 0.0677 0.0677
Chlamydia trachomatis DNA ligase 0.0009 0 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0303 0.0546
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.2368 0.2368
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.5558 0.5558
Onchocerca volvulus 0.0014 0.023 0.2519
Schistosoma mansoni Smad4 0.0016 0.0327 0.0589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0913 0.0913
Brugia malayi hypothetical protein 0.0038 0.1244 0.1244
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0913 0.0913
Schistosoma mansoni hypothetical protein 0.0064 0.2368 0.4261
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.023 0.0971
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0913 0.3856
Brugia malayi nuclear receptor NHR-67 0.0014 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.003 0.0913 0.0913
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0014 0.023 0.3395
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0913 0.0913
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0177 0.1421
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0913 0.1643
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.023 0.097
Schistosoma mansoni nuclear receptor 0.0014 0.023 0.0414
Brugia malayi tailless protein 0.0014 0.023 0.023
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0327 0.0589
Entamoeba histolytica hypothetical protein 0.0038 0.1244 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.2368 1
Schistosoma mansoni nuclear receptor 0.0014 0.023 0.0414
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.023 0.0971
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.2368 0.2368
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0677 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0913 0.0913
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0913 0.0913
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.023 0.0414
Echinococcus multilocularis Smad4 0.0016 0.0327 0.1382
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.023 0.0414
Brugia malayi hypothetical protein 0.0016 0.0302 0.0302
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0014 0.023 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0913 0.0913
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0913 0.0913
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.023 0.0414
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.8306 0.8306
Echinococcus granulosus bloom syndrome protein 0.0024 0.0662 0.2796
Echinococcus granulosus smad 0.0016 0.0327 0.1382
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0913 0.3856
Echinococcus granulosus Smad4 0.0016 0.0327 0.1382
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0138 0.5558 0.5558
Brugia malayi Latrophilin receptor protein 2 0.0064 0.2368 0.2368
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0913 0.0913
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0677 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0913 0.0913
Brugia malayi nuclear receptor NHR-88 0.0014 0.023 0.023
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0677 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.023 0.0971
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.023 0.097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.8306 0.8306
Schistosoma mansoni thyroid hormone receptor 0.003 0.0913 0.1643
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.003 0.0913 0.0913
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0177 0.2611
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0303 0.0303
Treponema pallidum DNA ligase (lig) 0.0009 0 0.5
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.023 0.3395
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.023 0.0971
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.005 0.0742
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.1244 0.5251
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0913 0.0913
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0327 0.1382
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.023 0.0414
Schistosoma mansoni smad1 5 8 and 0.0016 0.0327 0.0589
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0913 0.3856
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0316 0.4673
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0662 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0677 1
Brugia malayi MH2 domain containing protein 0.0016 0.0327 0.0327
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.023 0.097
Loa Loa (eye worm) Smad1 0.0016 0.0327 0.0327
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0677 1
Brugia malayi hypothetical protein 0.0014 0.023 0.023
Schistosoma mansoni nuclear hormone receptor 0.0014 0.023 0.0414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0913 0.0913
Schistosoma mansoni hypothetical protein 0.0064 0.2368 0.4261
Loa Loa (eye worm) hypothetical protein 0.0122 0.4866 0.4866
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.023 0.0971
Loa Loa (eye worm) hypothetical protein 0.001 0.005 0.005
Brugia malayi hypothetical protein 0.0014 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0303 0.0303
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0913 0.0913
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0913 0.0913
Echinococcus multilocularis GPCR, family 2 0.0064 0.2368 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0662 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.005 0.005
Brugia malayi MH2 domain containing protein 0.0016 0.0327 0.0327
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.023 0.0971
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.023 0.097
Echinococcus granulosus FTZ F1 alpha 0.003 0.0913 0.3856
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0303 0.0303
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0913 1
Entamoeba histolytica hypothetical protein 0.0038 0.1244 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0443 0.0797
Loa Loa (eye worm) hypothetical protein 0.003 0.0913 0.0913
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.005 0.0212
Entamoeba histolytica hypothetical protein 0.0038 0.1244 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.005 0.005
Brugia malayi nuclear receptor RXR 0.0014 0.023 0.023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.023 0.0971
Brugia malayi steroid hormone receptor 0.003 0.0913 0.0913
Brugia malayi hypothetical protein 0.0016 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0025 0.0677 0.0677
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0677 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0913 0.0913
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.023 0.023
Brugia malayi Isocitrate dehydrogenase 0.0014 0.023 0.023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.023 0.097
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0913 0.1643
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.023 0.2519
Schistosoma mansoni hypothetical protein 0.0011 0.0094 0.0169
Brugia malayi ecdysteroid receptor 0.003 0.0913 0.0913
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0303 0.0303
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0913 0.3856
Brugia malayi nuclear receptor RXR 0.0016 0.0303 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0913 0.0913
Schistosoma mansoni coup transcription factor 0.003 0.0913 0.1643
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0913 0.3856
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.2368 1
Echinococcus multilocularis smad 0.0016 0.0327 0.1382
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.023 0.0971
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0094 0.0397
Loa Loa (eye worm) nuclear factor I 0.0009 0.0011 0.0011
Loa Loa (eye worm) DR-78 0.0014 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0327 0.1382
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0202 0.8306 0.8306
Schistosoma mansoni smad1 5 8 and 0.0016 0.0327 0.0589
Loa Loa (eye worm) hypothetical protein 0.003 0.0913 0.0913
Loa Loa (eye worm) hypothetical protein 0.0016 0.0303 0.0303
Brugia malayi nuclear hormone receptor 0.003 0.0913 0.0913
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0327 0.0327
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0913 0.3856
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0327 0.0327
Schistosoma mansoni smad1 5 8 and 0.0016 0.0327 0.0589
Loa Loa (eye worm) hypothetical protein 0.0064 0.2368 0.2368
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.023 0.3395
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0913 0.1643
Loa Loa (eye worm) hypothetical protein 0.0014 0.023 0.023
Onchocerca volvulus 0.003 0.0913 1
Schistosoma mansoni zinc finger protein 0.0014 0.023 0.0414
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0913 0.1643

Activities

Activity type Activity value Assay description Source Reference
Reduction (functional) = 24 % Maximum reduction in plasma triglyceride levels in KKA mice at a dosage of 0.005% in diet ChEMBL. 1635060
Reduction (functional) = 24 % Maximum reduction in plasma triglyceride levels in KKA mice at a dosage of 0.005% in diet ChEMBL. 1635060
Reduction (functional) = 35 % Maximum reduction in blood glucose levels in KKA mice at a dosage of 0.005% in diet ChEMBL. 1635060
Reduction (functional) = 35 % Maximum reduction in blood glucose levels in KKA mice at a dosage of 0.005% in diet ChEMBL. 1635060

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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