Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.1294 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2981 | 0.3446 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2981 | 0.2981 |
Echinococcus multilocularis | acetylcholinesterase | 0.0146 | 0.6988 | 0.8078 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0198 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0063 | 0.2193 | 0.262 |
Echinococcus granulosus | acetylcholinesterase | 0.0146 | 0.6988 | 0.8351 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.1541 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2981 | 0.2981 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.2193 | 0.2535 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2981 | 0.3446 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2981 | 0.3446 |
Echinococcus multilocularis | GPCR, family 2 | 0.0063 | 0.2193 | 0.2535 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.8651 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0146 | 0.6988 | 0.8351 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2981 | 0.3446 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0063 | 0.2193 | 0.2193 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.5331 | 0.5331 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0063 | 0.2193 | 0.2193 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.1294 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.8369 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2981 | 0.3446 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.2193 | 0.2535 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.2193 | 0.2535 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.1541 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.1294 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0063 | 0.2193 | 0.2535 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2981 | 0.2981 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0146 | 0.6988 | 0.8078 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2981 | 0.2981 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0063 | 0.2193 | 0.2193 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2981 | 0.3562 |
Loa Loa (eye worm) | carboxylesterase | 0.0146 | 0.6988 | 0.6988 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.8651 | 0.8651 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.5331 | 0.5331 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0136 | 0.6386 | 0.6386 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.1541 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2981 | 0.2981 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.1541 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0146 | 0.6988 | 0.6988 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.6386 | 0.6386 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0063 | 0.2193 | 0.2535 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0146 | 0.6988 | 0.8078 |
Echinococcus multilocularis | acetylcholinesterase | 0.0146 | 0.6988 | 0.8078 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.1541 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.6988 | 0.6988 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0063 | 0.2193 | 0.262 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.8651 | 0.8651 |
Echinococcus granulosus | GPCR family 2 | 0.0063 | 0.2193 | 0.262 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.2193 | 0.2535 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.6386 | 0.7382 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.1541 | 0.1841 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.5331 | 0.5331 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.8651 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.6988 | 0.6988 |
Echinococcus granulosus | carboxylesterase 5A | 0.0146 | 0.6988 | 0.8351 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2981 | 0.3446 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.6988 | 0.6988 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2981 | 0.2981 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2193 | 0.2193 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.6988 | 0.6988 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.