Detailed information for compound 1456881

Basic information

Technical information
  • TDR Targets ID: 1456881
  • Name: N-(2,4-dimethylphenyl)-1-pyrazin-2-ylpiperidi ne-3-carboxamide
  • MW: 310.393 | Formula: C18H22N4O
  • H donors: 1 H acceptors: 3 LogP: 2.3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCN(C1)c1cnccn1)Nc1ccc(cc1C)C
  • InChi: 1S/C18H22N4O/c1-13-5-6-16(14(2)10-13)21-18(23)15-4-3-9-22(12-15)17-11-19-7-8-20-17/h5-8,10-11,15H,3-4,9,12H2,1-2H3,(H,21,23)
  • InChiKey: BIPFOTSXBKEMQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dimethylphenyl)-1-pyrazin-2-yl-piperidine-3-carboxamide
  • N-(2,4-dimethylphenyl)-1-(2-pyrazinyl)-3-piperidinecarboxamide
  • N-(2,4-dimethylphenyl)-1-pyrazin-2-yl-nipecotamide
  • NCGC00116894-01
  • D216-0929

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.3684 0.3684
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0584 0.1257
Giardia lamblia GTOR 0.0022 0.2501 0.9519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Schistosoma mansoni ferritin 0.001 0.082 0.082
Onchocerca volvulus 0.0035 0.4363 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.2501 0.679
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.2501 0.538
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.2628 0.7133
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1288
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.2628 0.7133
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.3684 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.2628 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.2508 0.6806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1288
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.1325 0.3596
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0584 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1288
Schistosoma mansoni ap endonuclease 0.0023 0.2628 0.2628
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.2501 0.538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.1121 0.3043
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.2501 0.2501
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1288
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.2501 0.9519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.2501 0.679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0716 0.1943
Schistosoma mansoni ferritin light chain 0.001 0.082 0.082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.1121 0.3043
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.001 0.0716 0.1539
Trichomonas vaginalis ferritin, putative 0.001 0.082 0.2225
Toxoplasma gondii exonuclease III APE 0.0023 0.2628 0.2966
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0012 0.1121 0.3043
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.2628 0.5651
Echinococcus multilocularis serine protein kinase ATM 0.003 0.3684 0.7923
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0891 0.2042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trichomonas vaginalis helicase, putative 0.0008 0.0474 0.1288
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.2628 0.7133
Echinococcus granulosus serine protein kinase ATM 0.003 0.3684 0.7923
Schistosoma mansoni cpg binding protein 0.0037 0.465 0.465
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.2501 0.679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.1325 0.3596
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.2501 0.9519
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1288
Echinococcus multilocularis cpg binding protein 0.0037 0.465 1
Schistosoma mansoni ferritin 0.001 0.082 0.082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0512 0.1389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.2628 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1288
Entamoeba histolytica hypothetical protein 0.003 0.3684 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1288
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.1121 0.1121
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0056 0.0056
Schistosoma mansoni ap endonuclease 0.0023 0.2628 0.2628
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.2501 0.5733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.2628 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.082 0.3119
Schistosoma mansoni ferritin 0.001 0.082 0.082
Echinococcus multilocularis expressed protein 0.001 0.082 0.1763
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.2501 0.679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Loa Loa (eye worm) hypothetical protein 0.0012 0.1121 0.2569
Schistosoma mansoni ferritin light chain 0.001 0.082 0.082
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0012 0.1121 0.3043
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0512 0.1389
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.2628 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.2628 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0474 0.1288
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.082 0.3119
Entamoeba histolytica protein kinase rad3, putative 0.0012 0.1121 0.3043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.1121 0.2569
Loa Loa (eye worm) hypothetical protein 0.0026 0.3075 0.7048
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.8861 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.1121 0.3043
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0871 0.1996
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.2628 0.7133
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.3075 0.8347
Schistosoma mansoni apoferritin-2 0.001 0.082 0.082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.1121 0.3043
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.2501 0.679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.1121 0.3043
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.1121 0.2411
Brugia malayi FAT domain containing protein 0.001 0.0716 0.1641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Schistosoma mansoni cpg binding protein 0.0037 0.465 0.465
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1288
Schistosoma mansoni hypothetical protein 0.001 0.0716 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.2501 0.9519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.4363 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.2628 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.3684 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.2501 0.5733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.001 0.0716 0.1539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Echinococcus granulosus expressed protein 0.001 0.082 0.1763
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.2501 0.679
Echinococcus multilocularis ferritin 0.001 0.082 0.1763
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.2508 0.9542
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.3684 0.8444
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.2501 0.538
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0584 0.1257
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.1121 0.2411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1288
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.2628 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.2628 0.7133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.2628 0.7133
Schistosoma mansoni cpg binding protein 0.0035 0.4363 0.4363
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.2501 0.679
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0014 0.1325 0.1495
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.2501 0.2823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.1121 0.3043
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.2628 0.6023
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1288
Schistosoma mansoni ferritin 0.001 0.082 0.082
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.3684 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Echinococcus granulosus cpg binding protein 0.0037 0.465 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.2501 0.679
Toxoplasma gondii FATC domain-containing protein 0.003 0.3684 0.4158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.2501 0.2501
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.2501 0.5733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.2501 0.679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Treponema pallidum bacterioferrin (TpF1) 0.001 0.082 0.3119
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.2628 0.6023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0584 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1288
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0891 0.1916
Brugia malayi CXXC zinc finger family protein 0.0035 0.4363 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.2501 0.9519
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.2501 0.679
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.1121 0.3043
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0474 0.1288
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.2501 0.9519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.1325 0.3596
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0891 0.1916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.2501 0.679
Echinococcus granulosus ferritin 0.001 0.082 0.1763
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.082 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.1325 0.3037
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.2501 0.538
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0584 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.2501 0.679
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.2501 0.5733
Loa Loa (eye worm) hypothetical protein 0.001 0.0716 0.1641
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.2628 0.5651
Schistosoma mansoni apoferritin-2 0.001 0.082 0.082
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.2628 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.2501 0.679

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.1192 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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