Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0899 | 0.3163 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.2609 | 1 | 1 |
Onchocerca volvulus | 0.0495 | 0.1547 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0539 | 0.1723 | 0.4076 |
Brugia malayi | glutaminase DH11.1 | 0.0265 | 0.0625 | 0.0625 |
Loa Loa (eye worm) | hypothetical protein | 0.1705 | 0.6384 | 0.6281 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0178 | 0.0276 | 0.0653 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0178 | 0.0276 | 0.0873 |
Loa Loa (eye worm) | hypothetical protein | 0.0539 | 0.1723 | 0.1488 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0539 | 0.1723 | 0.5447 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0899 | 0.3163 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0899 | 0.3163 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0539 | 0.1723 | 0.4076 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0899 | 0.3163 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0265 | 0.0625 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1165 | 0.4226 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0796 | 0.275 | 0.6506 |
Brugia malayi | Probable ClpP-like protease | 0.0899 | 0.3163 | 0.3163 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0899 | 0.3163 | 1 |
Schistosoma mansoni | smad | 0.0178 | 0.0276 | 0.0653 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0796 | 0.275 | 0.2544 |
Brugia malayi | MH1 domain containing protein | 0.0178 | 0.0276 | 0.0276 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0166 | 0.023 | 0.0729 |
Echinococcus multilocularis | GPCR, family 2 | 0.0539 | 0.1723 | 0.5447 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0371 | 0.1048 | 0.1034 |
Schistosoma mansoni | smad1 5 8 and | 0.0178 | 0.0276 | 0.0653 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0899 | 0.3163 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0539 | 0.1723 | 0.4076 |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 0.1547 | 0.1307 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0371 | 0.1048 | 0.1034 |
Brugia malayi | MH2 domain containing protein | 0.0178 | 0.0276 | 0.0276 |
Echinococcus multilocularis | smad | 0.0178 | 0.0276 | 0.0873 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0539 | 0.1723 | 0.5447 |
Loa Loa (eye worm) | TAR-binding protein | 0.0796 | 0.275 | 0.2544 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1705 | 0.6384 | 0.6384 |
Echinococcus multilocularis | tar DNA binding protein | 0.0796 | 0.275 | 0.8695 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0899 | 0.3163 | 0.7483 |
Schistosoma mansoni | tar DNA-binding protein | 0.0796 | 0.275 | 0.6506 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0589 | 0.1923 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0899 | 0.3163 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0796 | 0.275 | 0.8695 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0178 | 0.0276 | 0.0873 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0899 | 0.3163 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0796 | 0.275 | 0.275 |
Brugia malayi | hypothetical protein | 0.0495 | 0.1547 | 0.1547 |
Schistosoma mansoni | Smad4 | 0.0178 | 0.0276 | 0.0653 |
Leishmania major | hypothetical protein, conserved | 0.0371 | 0.1048 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0539 | 0.1723 | 0.4076 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0371 | 0.1048 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0265 | 0.0625 | 0.0359 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0371 | 0.1048 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1165 | 0.4226 | 0.4062 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.1705 | 0.6384 | 0.6384 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0899 | 0.3163 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0178 | 0.0276 | 0.0276 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0589 | 0.1923 | 0.4744 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0899 | 0.3163 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0899 | 0.3163 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 0.3163 | 0.2968 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0539 | 0.1723 | 0.5447 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1705 | 0.6384 | 0.6281 |
Schistosoma mansoni | tar DNA-binding protein | 0.0796 | 0.275 | 0.6506 |
Echinococcus granulosus | smad | 0.0178 | 0.0276 | 0.0873 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.023 | 0.0545 |
Brugia malayi | hypothetical protein | 0.0239 | 0.0523 | 0.0523 |
Echinococcus multilocularis | Smad4 | 0.0178 | 0.0276 | 0.0873 |
Brugia malayi | hypothetical protein | 0.0371 | 0.1048 | 0.1048 |
Echinococcus granulosus | GPCR family 2 | 0.0539 | 0.1723 | 0.5447 |
Schistosoma mansoni | glutaminase | 0.0265 | 0.0625 | 0.1479 |
Echinococcus granulosus | Smad4 | 0.0178 | 0.0276 | 0.0873 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0166 | 0.023 | 0.0729 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0589 | 0.1923 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1048 | 0.0794 |
Loa Loa (eye worm) | RNA binding protein | 0.0796 | 0.275 | 0.2544 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0371 | 0.1048 | 0.1034 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0371 | 0.1048 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0265 | 0.0625 | 0.0359 |
Schistosoma mansoni | smad1 5 8 and | 0.0178 | 0.0276 | 0.0653 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.1165 | 0.4226 | 0.4226 |
Schistosoma mansoni | tar DNA-binding protein | 0.0796 | 0.275 | 0.6506 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0539 | 0.1723 | 0.5447 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0371 | 0.1048 | 0.1034 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0178 | 0.0276 | 0.0873 |
Schistosoma mansoni | tar DNA-binding protein | 0.0796 | 0.275 | 0.6506 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0589 | 0.1923 | 0.6081 |
Brugia malayi | Smad1 | 0.0178 | 0.0276 | 0.0276 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0899 | 0.3163 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.2609 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0178 | 0.0276 | 0.0653 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0539 | 0.1723 | 0.1723 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0899 | 0.3163 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0539 | 0.1723 | 0.1488 |
Brugia malayi | TAR-binding protein | 0.0796 | 0.275 | 0.275 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0589 | 0.1923 | 0.6081 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0539 | 0.1723 | 0.1723 |
Brugia malayi | MH2 domain containing protein | 0.0178 | 0.0276 | 0.0276 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0178 | 0.0276 | 0.0873 |
Brugia malayi | RNA binding protein | 0.0796 | 0.275 | 0.275 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 uM | Inhibitory concentration of the compound required for 50% apoptosis induction was evaluated using jurkat cells (T-lymphoma cells); NT means not tested | ChEMBL. | 12182874 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.