Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5855 | 0.8901 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0903 | 0.1542 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0202 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0093 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.657 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0903 | 0.0903 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0903 | 0.1542 |
Onchocerca volvulus | 0.0033 | 0.0903 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.2589 | 0.3881 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0903 | 0.0845 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.2589 | 0.3881 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.5514 | 0.5485 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.5855 | 0.5855 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0.0063 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.2589 | 0.4421 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5855 | 0.8901 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5855 | 0.8901 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0064 | 0.2589 | 0.2542 |
Echinococcus granulosus | lamin | 0.0033 | 0.0903 | 0.1542 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.039 | 0.0502 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.5855 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0903 | 0.1542 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0903 | 0.0903 |
Schistosoma mansoni | lamin | 0.0033 | 0.0903 | 0.129 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.1904 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.2589 | 0.3881 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0138 | 0.657 | 0.6548 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5855 | 0.8901 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.2589 | 0.4421 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.1904 | 1 |
Brugia malayi | RNA binding protein | 0.0125 | 0.5855 | 0.5828 |
Echinococcus multilocularis | GPCR, family 2 | 0.0064 | 0.2589 | 0.4421 |
Echinococcus granulosus | GPCR family 2 | 0.0064 | 0.2589 | 0.4421 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.2589 | 0.4421 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.1904 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0903 | 0.1542 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0063 | 0.0108 |
Onchocerca volvulus | 0.0033 | 0.0903 | 0.5 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0063 | 0.0108 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0063 | 0.0063 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0063 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.5855 | 0.5855 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.5514 | 0.5514 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.1904 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.5855 | 0.5828 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.5855 | 1 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.5855 | 0.5828 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.657 | 0.657 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.1904 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2589 | 0.2589 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0063 | 0.0108 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.1904 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.039 | 0.0665 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0063 | 0.0108 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.1904 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.2589 | 0.3881 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.039 | 0.0665 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0871 | 0.0871 |
Schistosoma mansoni | lamin | 0.0033 | 0.0903 | 0.129 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0063 | 0.0108 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5855 | 0.8901 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0064 | 0.2589 | 0.2589 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0903 | 0.0903 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0903 | 0.129 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0064 | 0.2589 | 0.2542 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.1904 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0093 | 0.003 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.5514 | 0.5514 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0202 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0903 | 0.1542 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.5855 | 0.5855 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0903 | 0.0845 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1904 | 0.1904 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0931 | 0.0873 |
Brugia malayi | hypothetical protein | 0.0051 | 0.1904 | 0.1853 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.2589 | 0.4421 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.