Detailed information for compound 145702

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 290.483 | Formula: C20H34O
  • H donors: 1 H acceptors: 1 LogP: 7.07 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC/C=C\C/C=C\C=C\C=C\C(CCCCC)O
  • InChi: 1S/C20H34O/c1-3-5-7-8-9-10-11-12-13-14-15-17-19-20(21)18-16-6-4-2/h9-10,12-15,17,19-21H,3-8,11,16,18H2,1-2H3/b10-9-,13-12-,15-14+,19-17+
  • InChiKey: WBWQDCDHKBAYAF-PFKFLXLKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi DIX domain containing protein 0.0028 0.0044 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0101 0.0273 0.5311
Brugia malayi Calcitonin receptor-like protein seb-1 0.2394 0.7467 0.7462
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.02 0.0318
Loa Loa (eye worm) MH2 domain-containing protein 0.0218 0.064 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0178 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.02 0.3983
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0021 0.0022 0.0006
Plasmodium vivax replication factor C subunit 1, putative 0.0071 0.0178 0.3529
Loa Loa (eye worm) MH2 domain-containing protein 0.3201 1 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.02 1
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0021 0.0022 0.0025
Toxoplasma gondii LsmAD domain-containing protein 0.0101 0.0273 0.544
Brugia malayi latrophilin 2 splice variant baaae 0.1637 0.509 0.5081
Echinococcus granulosus mothers against decapentaplegic 2 0.0097 0.0262 0.0426
Brugia malayi Smad1 0.0218 0.064 0.0623
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.002 0.0019 0.0019
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0071 0.0178 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0071 0.0178 0.3353
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0028 0.0044 0.0044
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0028 0.0044 0.0036
Echinococcus granulosus nibrin 0.0071 0.0178 0.0278
Brugia malayi MH1 domain containing protein 0.0218 0.064 0.0623
Loa Loa (eye worm) nuclear factor I 0.0121 0.0334 0.0326
Brugia malayi regulator of G-protein signaling egl-10 0.0028 0.0044 0.0025
Trichomonas vaginalis replication factor C large subunit, putative 0.0071 0.0178 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0014
Schistosoma mansoni tar DNA-binding protein 0.1839 0.5727 1
Brugia malayi RNA binding protein 0.1839 0.5727 0.5719
Onchocerca volvulus 0.0602 0.1844 1
Brugia malayi MH1 domain containing protein 0.0121 0.0334 0.0316
Schistosoma mansoni hypothetical protein 0.0757 0.2332 0.4065
Loa Loa (eye worm) hypothetical protein 0.0757 0.2332 0.2326
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0036
Brugia malayi hypothetical protein 0.0028 0.0044 0.0025
Loa Loa (eye worm) MH1 domain-containing protein 0.0097 0.0262 0.0254
Schistosoma mansoni tar DNA-binding protein 0.1839 0.5727 1
Loa Loa (eye worm) hypothetical protein 0.0572 0.1751 0.1744
Brugia malayi DKFZp564C0469 protein 0.0071 0.0178 0.0159
Schistosoma mansoni dep domain containing protein 0.0028 0.0044 0.0064
Onchocerca volvulus 0.0028 0.0044 0.0139
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.004 0.054
Echinococcus granulosus Pleckstrin G protein interacting region 0.0028 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0071 0.0178 0.0169
Toxoplasma gondii hypothetical protein 0.0027 0.004 0.0801
Echinococcus granulosus TGF beta signal transducer SmadC 0.0218 0.064 0.1089
Schistosoma mansoni isocitrate dehydrogenase 0.0021 0.0022 0.0025
Onchocerca volvulus 0.0071 0.0178 0.0869
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0178 0.3282
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0022 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0101 0.0273 0.5261
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0116 0.527
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0044 0.0044
Brugia malayi MH2 domain containing protein 0.0097 0.0262 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0178 1
Brugia malayi Probable isocitrate dehydrogenase 0.0021 0.0022 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0178 1
Schistosoma mansoni hypothetical protein 0.1637 0.509 0.8887
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.1637 0.509 0.5086
Brugia malayi hypothetical protein 0.0065 0.0161 0.0142
Giardia lamblia Replication factor C, subunit 1 0.0071 0.0178 0.5
Brugia malayi MH1 domain containing protein 0.0121 0.0334 0.0316
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0019 0.0019
Schistosoma mansoni smad 0.0218 0.064 0.1106
Loa Loa (eye worm) transcription factor SMAD2 0.3201 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0262 0.0254
Schistosoma mansoni dishevelled 0.0028 0.0044 0.0064
Plasmodium falciparum ataxin-2 like protein, putative 0.0101 0.0273 0.5311
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0174 0.0502 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.02 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0174 0.0502 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0097 0.0262 0.0426
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0021 0.0022 0.0014
Toxoplasma gondii hypothetical protein 0.0028 0.0044 0.0883
Brugia malayi MH2 domain containing protein 0.0218 0.064 0.0623
Brugia malayi isocitrate dehydrogenase 0.0174 0.0502 0.0484
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0098 0.0139
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.1839 0.5727 0.5723
Loa Loa (eye worm) hypothetical protein 0.0071 0.0178 0.0169
Brugia malayi hypothetical protein 0.0071 0.0178 0.0159
Loa Loa (eye worm) hypothetical protein 0.0071 0.0178 0.0169
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0174 0.0502 0.0864
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0044 0.0025
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0044 0.0044
Schistosoma mansoni tar DNA-binding protein 0.1839 0.5727 1
Loa Loa (eye worm) RNA binding protein 0.1839 0.5727 0.5723
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.004 0.1002
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0019 0.0016 0.0014
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0021 0.0022 0.0003
Loa Loa (eye worm) isocitrate dehydrogenase 0.0174 0.0502 0.0494
Echinococcus multilocularis mothers against decapentaplegic 5 0.0218 0.064 0.1089
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.02 0.3989
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0044 0.0044
Schistosoma mansoni DNA ligase IV 0.0071 0.0178 0.0297
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0757 0.2332 0.4053
Leishmania major hypothetical protein, conserved 0.0101 0.0273 0.5228
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0174 0.0502 0.0847
Loa Loa (eye worm) hypothetical protein 0.0078 0.02 0.0192
Schistosoma mansoni Smad4 0.0218 0.064 0.1106
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.02 0.0318
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0021 0.0022 0.0003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.02 0.3819
Loa Loa (eye worm) RecQ helicase 0.0021 0.0022 0.0013
Echinococcus granulosus tar DNA binding protein 0.1839 0.5727 1
Loa Loa (eye worm) Smad1 0.0218 0.064 0.0632
Toxoplasma gondii isocitrate dehydrogenase 0.0174 0.0502 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0022 0.0178
Brugia malayi Probable ClpP-like protease 0.0078 0.02 0.0182
Schistosoma mansoni chromosome transmission fidelity factor 0.0071 0.0178 0.0297
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0021 0.0022 0.0213
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.2394 0.7467 0.7464
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0116 0.017
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0044 0.0044
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0022 0.0178
Loa Loa (eye worm) RasGEF domain-containing protein 0.002 0.0019 0.0011
Echinococcus granulosus GPCR family 2 0.0757 0.2332 0.4053
Brugia malayi hypothetical protein 0.0101 0.0273 0.0255
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0071 0.0178 0.3536
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0116 0.017
Schistosoma mansoni hypothetical protein 0.0757 0.2332 0.4065
Schistosoma mansoni smad1 5 8 and 0.0218 0.064 0.1106
Loa Loa (eye worm) RasGEF domain-containing protein 0.002 0.0019 0.0011
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0071 0.0178 1
Brugia malayi hypothetical protein 0.0071 0.0178 0.0159
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0174 0.0502 0.0847
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0071 0.0178 0.8721
Schistosoma mansoni hypothetical protein 0.0045 0.0098 0.0158
Schistosoma mansoni topbp1 0.0071 0.0178 0.0297
Loa Loa (eye worm) hypothetical protein 0.0121 0.0334 0.0326
Loa Loa (eye worm) RasGEF domain-containing protein 0.002 0.0019 0.0011
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0071 0.0178 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0036
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0021 0.0022 0.0003
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0021 0.0022 0.0006
Loa Loa (eye worm) hypothetical protein 0.2394 0.7467 0.7464
Loa Loa (eye worm) DIX domain-containing protein 0.0028 0.0044 0.0036
Plasmodium vivax ataxin-2 like protein, putative 0.0101 0.0273 0.5436
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0021 0.0022 0.0006
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.004 0.0791
Schistosoma mansoni regulator of G protein signaling 0.0028 0.0044 0.0064
Brugia malayi hypothetical protein 0.0602 0.1844 0.1828
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.02 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0019 0.0019
Toxoplasma gondii ATPase, AAA family protein 0.0071 0.0178 0.3536
Schistosoma mansoni smad1 5 8 and 0.0218 0.064 0.1106
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0071 0.0178 1
Schistosoma mansoni smad 0.0097 0.0262 0.0444
Trypanosoma brucei PAB1-binding protein , putative 0.0101 0.0273 0.2946
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0178 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0097 0.0262 0.0243
Echinococcus multilocularis Smad4 0.0218 0.064 0.1089
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.02 1
Brugia malayi RNA recognition motif domain containing protein 0.1839 0.5727 0.5719
Schistosoma mansoni hypothetical protein 0.0757 0.2332 0.4065
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0178 0.3282
Trypanosoma cruzi FHA domain containing protein, putative 0.0071 0.0178 0.3282
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0028 0.0044 0.0064
Brugia malayi topoisomerase 0.0071 0.0178 0.0159
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0174 0.0502 0.0847
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0178 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0116 0.1955
Echinococcus granulosus mothers against decapentaplegic 5 0.0218 0.064 0.1089
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0174 0.0502 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.002 0.0019 0.0019
Loa Loa (eye worm) TAR-binding protein 0.1839 0.5727 0.5723
Echinococcus multilocularis mothers against decapentaplegic 2 0.0097 0.0262 0.0426
Schistosoma mansoni unc-13 (munc13) 0.0021 0.0022 0.0025
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0218 0.064 0.1089
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0097 0.0262 0.1331
Echinococcus multilocularis GPCR, family 2 0.0757 0.2332 0.4053
Loa Loa (eye worm) MH1 domain-containing protein 0.0218 0.064 0.0632
Schistosoma mansoni tar DNA-binding protein 0.1839 0.5727 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0572 0.1751 0.9493
Loa Loa (eye worm) hypothetical protein 0.0101 0.0273 0.0265
Treponema pallidum DNA ligase (lig) 0.0071 0.0178 0.8578
Echinococcus granulosus bloom syndrome protein 0.0021 0.0022 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0757 0.2332 0.2318
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.02 1
Echinococcus granulosus replication factor c subunit 1 0.0071 0.0178 0.0278
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0174 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0757 0.2332 0.4053
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0174 0.0502 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0757 0.2332 0.2318
Loa Loa (eye worm) hypothetical protein 0.0071 0.0178 0.0169
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0757 0.2332 0.4053
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.02 0.0336
Loa Loa (eye worm) hypothetical protein 0.0602 0.1844 0.1837
Toxoplasma gondii isocitrate dehydrogenase 0.0174 0.0502 1
Schistosoma mansoni z-protein (S1r protein) 0.0028 0.0044 0.0064
Schistosoma mansoni dishevelled 0.0028 0.0044 0.0064
Schistosoma mansoni tar DNA-binding protein 0.1839 0.5727 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0098 0.0139
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0071 0.0178 0.0159
Echinococcus multilocularis replication factor c subunit 1 0.0071 0.0178 0.0278
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0028 0.0044 0.0139
Entamoeba histolytica tartrate dehydrogenase, putative 0.0021 0.0022 0.0213
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.2394 0.7467 0.7462
Echinococcus multilocularis isocitrate dehydrogenase 0.0174 0.0502 0.0847
Brugia malayi Isocitrate dehydrogenase 0.0174 0.0502 0.0484
Loa Loa (eye worm) hypothetical protein 0.0071 0.0178 0.0169
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0044 0.0044
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0174 0.0502 0.0847
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0071 0.0178 0.3282
Brugia malayi MH2 domain containing protein 0.0218 0.064 0.0623
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0011
Brugia malayi MH1 domain containing protein 0.0218 0.064 0.0623
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0071 0.0178 0.8721
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0021 0.0022 0.0006
Echinococcus granulosus Smad4 0.0218 0.064 0.1089
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0174 0.0502 1
Schistosoma mansoni Smad4 0.0097 0.0262 0.0444
Loa Loa (eye worm) hypothetical protein 0.0071 0.0178 0.0169
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0071 0.0178 0.8721
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0757 0.2332 0.4053
Brugia malayi TAR-binding protein 0.1839 0.5727 0.5719
Brugia malayi Pax transcription activation domain interacting protein 0.0071 0.0178 0.0159
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0044 0.0044
Echinococcus granulosus smad 0.0218 0.064 0.1089
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0116 0.1955
Loa Loa (eye worm) MH2 domain-containing protein 0.0097 0.0262 0.0254
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0218 0.064 0.1106
Schistosoma mansoni Smad4 0.0097 0.0262 0.0444
Loa Loa (eye worm) latrophilin receptor protein 2 0.0757 0.2332 0.2326
Brugia malayi hypothetical protein 0.0028 0.0044 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0101 0.0273 0.5261
Schistosoma mansoni hypothetical protein 0.0757 0.2332 0.4065
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.02 0.3989
Echinococcus granulosus mothers against decapentaplegic 6 0.0097 0.0262 0.0426
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0174 0.0502 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0174 0.0502 0.0847
Echinococcus multilocularis nibrin 0.0071 0.0178 0.0278
Brugia malayi N-terminal motif family protein 0.0572 0.1751 0.1735
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.02 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0174 0.0502 1
Echinococcus multilocularis smad 0.0218 0.064 0.1089
Brugia malayi Probable isocitrate dehydrogenase 0.0021 0.0022 0.0003
Entamoeba histolytica hypothetical protein 0.0071 0.0178 1
Schistosoma mansoni ras GTP exchange factor 0.002 0.0019 0.0019
Echinococcus multilocularis tar DNA binding protein 0.1839 0.5727 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0071 0.0178 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0044 0.0025
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0022 0.0003
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.02 1
Schistosoma mansoni smad1 5 8 and 0.0218 0.064 0.1106
Schistosoma mansoni topbp1 0.0071 0.0178 0.0297

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 95 % Inhibition of 5-lipoxygenase was evaluated in human polymorphonuclear leukocytes stimulated by calcium ionophore A-23,187 for formation of 5-HETE at 10 uM ChEMBL. No reference
Inhibition (binding) = 95 % Inhibition of 5-lipoxygenase was evaluated in human polymorphonuclear leukocytes stimulated by calcium ionophore A-23,187 for formation of LTB4 at 10 uM ChEMBL. No reference
Inhibition (binding) = 95 % Inhibition of 5-lipoxygenase was evaluated in human polymorphonuclear leukocytes stimulated by calcium ionophore A-23,187 for formation of 5-HETE at 10 uM ChEMBL. No reference
Inhibition (binding) = 95 % Inhibition of 5-lipoxygenase was evaluated in human polymorphonuclear leukocytes stimulated by calcium ionophore A-23,187 for formation of LTB4 at 10 uM ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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