Detailed information for compound 1457065

Basic information

Technical information
  • TDR Targets ID: 1457065
  • Name: 3-(cyclohexylcarbamoylamino)-N-(phenylmethyl) -8-azabicyclo[3.2.1]octane-8-carboxamide
  • MW: 384.515 | Formula: C22H32N4O2
  • H donors: 3 H acceptors: 2 LogP: 3.17 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1C2CCC1CC(C2)NC(=O)NC1CCCCC1)NCc1ccccc1
  • InChi: 1S/C22H32N4O2/c27-21(24-17-9-5-2-6-10-17)25-18-13-19-11-12-20(14-18)26(19)22(28)23-15-16-7-3-1-4-8-16/h1,3-4,7-8,17-20H,2,5-6,9-15H2,(H,23,28)(H2,24,25,27)
  • InChiKey: FDOCICZHYUOUEY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[[(cyclohexylamino)-oxomethyl]amino]-N-(phenylmethyl)-8-azabicyclo[3.2.1]octane-8-carboxamide
  • N-(benzyl)-3-(cyclohexylcarbamoylamino)-8-azabicyclo[3.2.1]octane-8-carboxamide
  • ASN 06444208
  • 3-(3-Cyclohexyl-ureido)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid benzylamide
  • MLS000070973
  • SMR000006684

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0172 0.0505 0.1086
Loa Loa (eye worm) MH2 domain-containing protein 0.2595 1 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0025 0.0288
Echinococcus multilocularis mothers against decapentaplegic 5 0.0177 0.0523 0.1322
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0813 0.3018 1
Schistosoma mansoni tar DNA-binding protein 0.1052 0.3955 0.851
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.0409 0.1033
Brugia malayi MH2 domain containing protein 0.0177 0.0523 0.0523
Schistosoma mansoni DNA ligase IV 0.005 0.0025 0.0054
Loa Loa (eye worm) latrophilin receptor protein 2 0.0569 0.206 0.2059
Schistosoma mansoni smad1 5 8 and 0.0177 0.0523 0.1124
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0177 0.0523 0.1322
Loa Loa (eye worm) hypothetical protein 0.0085 0.0165 0.0164
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0019 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0569 0.206 0.5208
Toxoplasma gondii ATPase, AAA family protein 0.005 0.0025 0.0082
Schistosoma mansoni hypothetical protein 0.0058 0.0058 0.0125
Schistosoma mansoni hypothetical protein 0.0148 0.0409 0.0878
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0813 0.3018 1
Brugia malayi MH1 domain containing protein 0.0177 0.0523 0.0523
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0 0.0001
Brugia malayi MH1 domain containing protein 0.0177 0.0523 0.0523
Schistosoma mansoni tar DNA-binding protein 0.1052 0.3955 0.851
Loa Loa (eye worm) hypothetical protein 0.005 0.0025 0.0025
Loa Loa (eye worm) nuclear factor I 0.0098 0.0213 0.0213
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.0409 0.0878
Brugia malayi MH1 domain containing protein 0.0098 0.0213 0.0213
Onchocerca volvulus 0.0296 0.0992 0.7577
Plasmodium vivax ataxin-2 like protein, putative 0.0384 0.1335 0.4424
Trypanosoma cruzi PAB1-binding protein , putative 0.0384 0.1335 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0019 0.0061
Brugia malayi Smad1 0.0177 0.0523 0.0523
Echinococcus granulosus mothers against decapentaplegic 2 0.0079 0.014 0.0353
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0177 0.0523 0.1124
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.005 0.0025 0.0082
Loa Loa (eye worm) hypothetical protein 0.005 0.0025 0.0025
Schistosoma mansoni smad 0.0177 0.0523 0.1124
Brugia malayi hypothetical protein 0.005 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0813 0.3018 0.3018
Mycobacterium ulcerans glutaminase 0.0264 0.0865 0.2865
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0019 0.0138
Loa Loa (eye worm) hypothetical protein 0.0296 0.0992 0.0991
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0813 0.3018 0.7631
Schistosoma mansoni chromosome transmission fidelity factor 0.005 0.0025 0.0054
Echinococcus granulosus nibrin 0.005 0.0025 0.0064
Loa Loa (eye worm) MH2 domain-containing protein 0.0177 0.0523 0.0523
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0533 0.192 1
Echinococcus granulosus Smad4 0.0177 0.0523 0.1322
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.0547 0.1384
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0025 0.0186
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.0409 0.1033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1798 0.6877 0.6877
Brugia malayi N-terminal motif family protein 0.0377 0.1309 0.1308
Loa Loa (eye worm) hypothetical protein 0.005 0.0025 0.0025
Brugia malayi DKFZp564C0469 protein 0.005 0.0025 0.0025
Onchocerca volvulus 0.0058 0.0058 0.0442
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0377 0.1309 1
Echinococcus multilocularis GPCR, family 2 0.0569 0.206 0.5208
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.005 0.0025 0.0082
Giardia lamblia Replication factor C, subunit 1 0.005 0.0025 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0025 0.0186
Schistosoma mansoni tar DNA-binding protein 0.1052 0.3955 0.851
Onchocerca volvulus 0.005 0.0025 0.019
Brugia malayi Pax transcription activation domain interacting protein 0.005 0.0025 0.0025
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.028 0.0928 0.3075
Plasmodium falciparum ataxin-2 like protein, putative 0.0384 0.1335 0.4389
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.028 0.0928 0.3018
Entamoeba histolytica hypothetical protein 0.0148 0.0409 1
Brugia malayi hypothetical protein 0.0384 0.1335 0.1335
Schistosoma mansoni Smad4 0.0079 0.014 0.03
Entamoeba histolytica hypothetical protein 0.0148 0.0409 1
Schistosoma mansoni Smad4 0.0177 0.0523 0.1124
Brugia malayi hypothetical protein 0.0148 0.0409 0.0408
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0813 0.3018 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0023 0.0022
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0019 0.0138
Schistosoma mansoni smad1 5 8 and 0.0177 0.0523 0.1124
Schistosoma mansoni survival motor neuron protein 0.0058 0.0058 0.0125
Entamoeba histolytica hypothetical protein 0.0148 0.0409 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.005 0.0025 0.0186
Schistosoma mansoni peptidase Clp (S14 family) 0.0813 0.3018 0.6494
Brugia malayi RNA recognition motif domain containing protein 0.1052 0.3955 0.3955
Schistosoma mansoni hypothetical protein 0.0569 0.206 0.4432
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1798 0.6877 0.6877
Brugia malayi TAR-binding protein 0.1052 0.3955 0.3955
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0813 0.3018 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0019 0.0048
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.028 0.0928 0.3075
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.005 0.0025 0.0288
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.005 0.0025 0.0288
Echinococcus multilocularis mothers against decapentaplegic 2 0.0079 0.014 0.0353
Plasmodium falciparum replication factor C subunit 1, putative 0.005 0.0025 0.0021
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0813 0.3018 0.7631
Brugia malayi MH2 domain containing protein 0.0177 0.0523 0.0523
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.0547 0.0547
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0547 0.1177
Echinococcus multilocularis nibrin 0.005 0.0025 0.0064
Schistosoma mansoni topbp1 0.005 0.0025 0.0054
Brugia malayi RNA binding protein 0.1052 0.3955 0.3955
Schistosoma mansoni smad 0.0079 0.014 0.03
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.005 0.0025 0.0288
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0533 0.192 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0019 0.0138
Echinococcus granulosus GPCR family 2 0.0569 0.206 0.5208
Loa Loa (eye worm) hypothetical protein 0.0079 0.014 0.0139
Schistosoma mansoni topbp1 0.005 0.0025 0.0054
Brugia malayi hypothetical protein 0.0296 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.1798 0.6877 0.6877
Trichomonas vaginalis glutaminase, putative 0.0264 0.0865 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0019 0.0018
Brugia malayi topoisomerase 0.005 0.0025 0.0025
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0813 0.3018 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0058 0.0058
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0813 0.3018 1
Brugia malayi Bromodomain containing protein 0.0046 0.0011 0.0011
Loa Loa (eye worm) RNA binding protein 0.1052 0.3955 0.3955
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0813 0.3018 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.0949 0.0949
Plasmodium vivax replication factor C subunit 1, putative 0.005 0.0025 0.0082
Echinococcus granulosus mothers against decapentaplegic 5 0.0177 0.0523 0.1322
Loa Loa (eye worm) hypothetical protein 0.0052 0.0032 0.0031
Brugia malayi glutaminase DH11.1 0.0264 0.0865 0.0865
Echinococcus granulosus TGF beta signal transducer SmadC 0.0177 0.0523 0.1322
Schistosoma mansoni Smad4 0.0079 0.014 0.03
Loa Loa (eye worm) hypothetical protein 0.005 0.0025 0.0025
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0533 0.192 0.636
Echinococcus multilocularis peptidase Clp (S14 family) 0.0533 0.192 0.4854
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0025 0.0288
Toxoplasma gondii hypothetical protein 0.028 0.0928 0.3075
Entamoeba histolytica hypothetical protein 0.0148 0.0409 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0569 0.206 0.5208
Brugia malayi mothers against decapentaplegic homolog 3 0.0079 0.014 0.0139
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0019 0.0048
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0813 0.3018 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.0547 0.0547
Trypanosoma cruzi FHA domain containing protein, putative 0.005 0.0025 0.0186
Loa Loa (eye worm) Smad1 0.0177 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.005 0.0025 0.0025
Loa Loa (eye worm) glutaminase 0.0264 0.0865 0.0865
Trypanosoma cruzi PAB1-binding protein , putative 0.0384 0.1335 1
Echinococcus granulosus smad 0.0177 0.0523 0.1322
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0019 0.0018
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0172 0.0505 0.1277
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0025 0.0288
Echinococcus multilocularis Smad4 0.0177 0.0523 0.1322
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0019 0.0048
Brugia malayi hypothetical protein 0.0286 0.0949 0.0949
Brugia malayi Bromodomain containing protein 0.0091 0.0185 0.0185
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0079 0.014 0.1065
Echinococcus granulosus replication factor c subunit 1 0.005 0.0025 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0025 0.0288
Brugia malayi MH2 domain containing protein 0.0079 0.014 0.0139
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0813 0.3018 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0113 0.0284
Echinococcus granulosus mothers against decapentaplegic 6 0.0079 0.014 0.0353
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0172 0.0505 0.1277
Loa Loa (eye worm) hypothetical protein 0.1229 0.4647 0.4647
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0547 0.1177
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0569 0.206 0.5208
Trichomonas vaginalis replication factor C large subunit, putative 0.005 0.0025 0.0288
Schistosoma mansoni glutaminase 0.0264 0.0865 0.1861
Brugia malayi Calcitonin receptor-like protein seb-1 0.1798 0.6877 0.6877
Schistosoma mansoni hypothetical protein 0.0569 0.206 0.4432
Echinococcus granulosus tar DNA binding protein 0.1052 0.3955 1
Brugia malayi isocitrate dehydrogenase 0.0048 0.0019 0.0018
Trypanosoma brucei PAB1-binding protein , putative 0.0384 0.1335 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0569 0.206 0.4432
Loa Loa (eye worm) glutaminase 2 0.0264 0.0865 0.0865
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0949 0.24
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.0547 0.1384
Plasmodium falciparum ataxin-2 like protein, putative 0.0384 0.1335 0.4389
Schistosoma mansoni hypothetical protein 0.0569 0.206 0.4432
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.0547 0.1384
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0019 0.0138
Loa Loa (eye worm) hypothetical protein 0.0377 0.1309 0.1308
Toxoplasma gondii LsmAD domain-containing protein 0.0384 0.1335 0.4424
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0813 0.3018 1
Schistosoma mansoni hypothetical protein 0.1229 0.4647 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0949 0.24
Brugia malayi hypothetical protein 0.005 0.0025 0.0025
Loa Loa (eye worm) MH1 domain-containing protein 0.0177 0.0523 0.0523
Schistosoma mansoni smad1 5 8 and 0.0177 0.0523 0.1124
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0919 0.4785
Schistosoma mansoni tar DNA-binding protein 0.1052 0.3955 0.851
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0113 0.0284
Loa Loa (eye worm) hypothetical protein 0.0098 0.0213 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0025 0.0288
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.1052 0.3955 0.3955
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0019 0.0048
Loa Loa (eye worm) hypothetical protein 0.0569 0.206 0.2059
Schistosoma mansoni bromodomain containing protein 0.0076 0.0129 0.0278
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0019 0.0096
Echinococcus multilocularis smad 0.0177 0.0523 0.1322
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0569 0.206 0.5208
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0019 0.0048
Loa Loa (eye worm) hypothetical protein 0.005 0.0025 0.0025
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0813 0.3018 1
Brugia malayi Probable ClpP-like protease 0.0813 0.3018 0.3018
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0019 0.0061
Schistosoma mansoni tar DNA-binding protein 0.1052 0.3955 0.851
Echinococcus multilocularis replication factor c subunit 1 0.005 0.0025 0.0064
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.028 0.0928 0.3032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.0547 0.1384
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.005 0.0025 0.0288
Loa Loa (eye worm) MH1 domain-containing protein 0.0079 0.014 0.0139
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.005 0.0025 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0079 0.014 0.0139
Leishmania major hypothetical protein, conserved 0.0384 0.1335 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0569 0.206 0.2059
Brugia malayi MH1 domain containing protein 0.0098 0.0213 0.0213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0547 0.1177
Loa Loa (eye worm) TAR-binding protein 0.1052 0.3955 0.3955
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.005 0.0025 0.0082
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0019 0.0061
Loa Loa (eye worm) transcription factor SMAD2 0.2595 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0019 0.004
Loa Loa (eye worm) hypothetical protein 0.0384 0.1335 0.1335
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.005 0.0025 0.0186
Echinococcus multilocularis mothers against decapentaplegic 6 0.0079 0.014 0.0353
Brugia malayi hypothetical protein 0.0248 0.0802 0.0801
Brugia malayi Latrophilin receptor protein 2 0.0569 0.206 0.2059
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0019 0.0138
Echinococcus granulosus peptidase Clp S14 family 0.0533 0.192 0.4854
Brugia malayi latrophilin 2 splice variant baaae 0.1229 0.4647 0.4647
Echinococcus multilocularis tar DNA binding protein 0.1052 0.3955 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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