Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.2427 | 0.2427 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0276 | 0.4095 | 0.4095 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0087 | 0.0492 | 0.0492 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1359 | 0.1359 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0087 | 0.0492 | 0.0492 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0087 | 0.0492 | 0.0492 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.4095 | 0.4095 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0133 | 0.1359 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.02 | 0.2648 | 0.2648 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0188 | 0.2427 | 0.2427 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2648 | 0.2648 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0276 | 0.4095 | 0.4095 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0276 | 0.4095 | 0.4095 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0585 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0585 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0585 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0133 | 0.1359 | 1 |
Brugia malayi | hypothetical protein | 0.0086 | 0.046 | 0.046 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0087 | 0.0492 | 0.0492 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0585 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0585 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0087 | 0.0492 | 0.0492 |
Loa Loa (eye worm) | RNA binding protein | 0.02 | 0.2648 | 0.2648 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0087 | 0.0492 | 0.0492 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0133 | 0.1359 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0492 | 0.0492 |
Brugia malayi | RNA recognition motif domain containing protein | 0.02 | 0.2648 | 0.2648 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0492 | 0.0492 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0087 | 0.0492 | 0.0492 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2648 | 0.2648 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2648 | 0.2648 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0133 | 0.1359 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0133 | 0.1359 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0133 | 0.1359 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0585 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2648 | 0.2648 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.2427 | 0.2427 |
Leishmania major | hypothetical protein, conserved | 0.0133 | 0.1359 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0492 | 0.0492 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0087 | 0.0492 | 0.0492 |
Schistosoma mansoni | tar DNA-binding protein | 0.02 | 0.2648 | 0.2648 |
Echinococcus multilocularis | GPCR, family 2 | 0.0087 | 0.0492 | 0.0492 |
Loa Loa (eye worm) | TAR-binding protein | 0.02 | 0.2648 | 0.2648 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0492 | 0.0492 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0133 | 0.1359 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.02 | 0.2648 | 0.2648 |
Brugia malayi | TAR-binding protein | 0.02 | 0.2648 | 0.2648 |
Brugia malayi | hypothetical protein | 0.0133 | 0.1359 | 0.1359 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.02 | 0.2648 | 0.2648 |
Echinococcus granulosus | tar DNA binding protein | 0.02 | 0.2648 | 0.2648 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 0.0492 | 0.0492 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0794 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.