Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.1039 | 0.1277 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.0096 | 0.0249 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0571 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0396 | 0.3615 | 0.3561 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0125 | 0.1039 | 0.1277 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1068 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0062 | 0.0441 | 0.0412 |
Schistosoma mansoni | smad | 0.0073 | 0.0538 | 0.0553 |
Echinococcus multilocularis | smad | 0.0073 | 0.0538 | 0.0553 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.076 | 0.7072 | 0.7047 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0181 | 0.0181 |
Echinococcus granulosus | smad | 0.0073 | 0.0538 | 0.0553 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0376 | 0.3417 | 0.4715 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0396 | 0.3615 | 0.3615 |
Schistosoma mansoni | smad1 5 8 and | 0.0073 | 0.0538 | 0.0553 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0062 | 0.0441 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.0441 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0062 | 0.0441 | 0.7316 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0181 | 0.0037 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0181 | 0.0037 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0033 | 0.0156 | 0.0072 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0322 | 0.024 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.0359 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.0412 |
Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.0293 | 0.2636 | 0.2592 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0125 | 0.1039 | 0.1039 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0073 | 0.0538 | 0.0458 |
Loa Loa (eye worm) | nuclear factor I | 0.004 | 0.0229 | 0.0146 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.0571 | 0.0601 |
Brugia malayi | RNA recognition motif domain containing protein | 0.076 | 0.7072 | 0.7072 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.1031 | 0.965 | 1 |
Brugia malayi | RNA binding protein | 0.076 | 0.7072 | 0.7072 |
Schistosoma mansoni | tar DNA-binding protein | 0.076 | 0.7072 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0033 | 0.0156 | 0.0072 |
Loa Loa (eye worm) | RNA binding protein | 0.076 | 0.7072 | 0.7047 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0125 | 0.1039 | 0.1277 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.3615 | 0.3561 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0181 | 0.0037 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0181 | 0.0037 |
Schistosoma mansoni | smad1 5 8 and | 0.0073 | 0.0538 | 0.0553 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0062 | 0.0441 | 1 |
Brugia malayi | Smad1 | 0.0073 | 0.0538 | 0.0538 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0571 | 0.0601 |
Schistosoma mansoni | tar DNA-binding protein | 0.076 | 0.7072 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0571 | 0.0601 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0062 | 0.0441 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0062 | 0.0441 | 0.7316 |
Brugia malayi | MH2 domain containing protein | 0.0073 | 0.0538 | 0.0538 |
Schistosoma mansoni | smad1 5 8 and | 0.0073 | 0.0538 | 0.0553 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.0322 | 0.4744 |
Echinococcus granulosus | Smad4 | 0.0073 | 0.0538 | 0.0553 |
Echinococcus multilocularis | GPCR, family 2 | 0.0125 | 0.1039 | 0.1277 |
Brugia malayi | Isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.0441 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0033 | 0.0156 | 0.0156 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.7316 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0229 | 0.0146 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0125 | 0.1039 | 0.0963 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.2423 | 0.3278 |
Echinococcus multilocularis | Smad4 | 0.0073 | 0.0538 | 0.0553 |
Brugia malayi | MH2 domain containing protein | 0.0033 | 0.0156 | 0.0156 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.7316 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0073 | 0.0538 | 0.0553 |
Schistosoma mansoni | tar DNA-binding protein | 0.076 | 0.7072 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.0412 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0073 | 0.0538 | 0.0553 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0026 | 0.0096 | 0.0249 |
Entamoeba histolytica | hypothetical protein | 0.0293 | 0.2636 | 0.2592 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0062 | 0.0441 | 1 |
Schistosoma mansoni | Smad4 | 0.0073 | 0.0538 | 0.0553 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0571 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0073 | 0.0538 | 0.0538 |
Onchocerca volvulus | Mothers against decapentaplegic homolog | 0.0033 | 0.0156 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0125 | 0.1039 | 0.1039 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0396 | 0.3615 | 0.3615 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0571 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0571 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.1039 | 0.1277 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0571 | 0.0571 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0376 | 0.3417 | 0.4715 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0571 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0125 | 0.1039 | 0.1277 |
Echinococcus multilocularis | tar DNA binding protein | 0.076 | 0.7072 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.1039 | 0.1277 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.1039 | 0.1277 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0062 | 0.0441 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0571 | 0.5 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0073 | 0.0538 | 0.0553 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0571 | 0.0491 |
Brugia malayi | MH1 domain containing protein | 0.0073 | 0.0538 | 0.0538 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0571 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.004 | 0.0229 | 0.0229 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0062 | 0.0441 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1068 | 1 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0571 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0125 | 0.1039 | 0.1277 |
Brugia malayi | MH1 domain containing protein | 0.004 | 0.0229 | 0.0229 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0125 | 0.1039 | 0.1277 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.0096 | 0.0249 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0571 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.076 | 0.7072 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0073 | 0.0538 | 0.0553 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.0412 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0322 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1039 | 0.0963 |
Loa Loa (eye worm) | Smad1 | 0.0073 | 0.0538 | 0.0458 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0571 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0571 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.0412 |
Giardia lamblia | DNA repair protein RAD52 | 0.1031 | 0.965 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0271 | 0.2423 | 0.2423 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.0412 |
Brugia malayi | TAR-binding protein | 0.076 | 0.7072 | 0.7072 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0062 | 0.0441 | 0.0412 |
Schistosoma mansoni | tar DNA-binding protein | 0.076 | 0.7072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.2423 | 0.2359 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0073 | 0.0538 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0156 | 0.0072 |
Schistosoma mansoni | tar DNA-binding protein | 0.076 | 0.7072 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.076 | 0.7072 | 0.7047 |
Brugia malayi | MH2 domain containing protein | 0.0073 | 0.0538 | 0.0538 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0073 | 0.0538 | 0.0553 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.