Detailed information for compound 145730

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 464.918 | Formula: C18H25ClN2O8S
  • H donors: 3 H acceptors: 7 LogP: 1.18 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCN(c1ccc(cc1)C(=O)N[C@H](C(=O)O)CCCC(=O)O)CCOS(=O)(=O)C
  • InChi: 1S/C18H25ClN2O8S/c1-30(27,28)29-12-11-21(10-9-19)14-7-5-13(6-8-14)17(24)20-15(18(25)26)3-2-4-16(22)23/h5-8,15H,2-4,9-12H2,1H3,(H,20,24)(H,22,23)(H,25,26)/t15-/m0/s1
  • InChiKey: HRKVIFPMHXTMGN-HNNXBMFYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0411 0.5047 0.5901
Trichomonas vaginalis conserved hypothetical protein 0.0411 0.5047 0.5901
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0021 0.0021
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.1181 0.2923
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1335 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.008 0.0818 0.0818
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.004 0.0313 0.0367
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0911 0.1066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0818 0.0957
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0281 0.0281
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.002 0.0055 0.0064
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.077 0.0889
Schistosoma mansoni protein farnesyltransferase subunit beta 0.002 0.0055 0.01
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1335 0.3308
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0156 0.1787 0.3245
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0911 0.1653
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0047 0.0399 0.0725
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0411 0.5047 0.9163
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0818 0.0957
Trypanosoma cruzi lanosterol synthase, putative 0.0145 0.1653 0.1924
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0281 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-41 0.008 0.0818 0.0957
Loa Loa (eye worm) hypothetical protein 0.0237 0.2826 0.3307
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0015 0.0027
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.033 0.4014 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0307
Onchocerca volvulus Protein ultraspiracle homolog 0.008 0.0818 0.1113
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0135 0.1635
Echinococcus granulosus nAChR subunit 0.0047 0.0399 0.0725
Schistosoma mansoni hypothetical protein 0.0034 0.023 0.0418
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0101 0.0105
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0156 0.1787 0.3245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0368 0.0668
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0101 0.0105
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.002 0.0055 0.0051
Brugia malayi beta-lactamase family protein 0.0036 0.0262 0.0307
Schistosoma mansoni zinc finger protein 0.0038 0.0281 0.051
Echinococcus granulosus protein farnesyltransferase subunit beta 0.002 0.0055 0.01
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0087 0.0911 0.1066
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0562 0.1375
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0023 0.0027
Plasmodium falciparum importin beta, putative 0.0029 0.017 0.0316
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0281 0.051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.008 0.0818 0.0957
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0073 0.0123
Brugia malayi steroid hormone receptor 0.008 0.0818 0.0957
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.077 0.0889
Loa Loa (eye worm) hypothetical protein 0.0156 0.1787 0.2092
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0114 0.0204
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0562 0.102
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.077 0.1398
Loa Loa (eye worm) hypothetical protein 0.0299 0.3621 0.4237
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0406 0.0406
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0262 0.1876
Loa Loa (eye worm) hypothetical protein 0.0033 0.0224 0.0262
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0411 0.5047 1
Brugia malayi hypothetical protein 0.0042 0.0338 0.0396
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.002 0.0055 0.01
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0368 0.0431
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0406 0.0785
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Echinococcus multilocularis glycine receptor subunit beta 0.0087 0.0911 0.0911
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0114 0.0204
Brugia malayi hypothetical protein 0.004 0.0313 0.0367
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0281 0.0329
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.004 0.0313 0.0313
Entamoeba histolytica Ran family GTPase 0.0021 0.0073 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.002 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0307
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.0338 0.0338
Schistosoma mansoni ran 0.0021 0.0073 0.0133
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0101 0.0105
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Echinococcus granulosus glycine receptor subunit beta 0.0087 0.0911 0.1653
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0685 0.8545 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0073 0.0073
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0328 0.3983 0.4661
Schistosoma mansoni nAChR subunit 0.0087 0.0911 0.1653
Onchocerca volvulus 0.0048 0.0419 0.0448
Onchocerca volvulus 0.0156 0.1787 0.2727
Leishmania major GTP-binding protein, putative 0.0021 0.0073 0.0072
Toxoplasma gondii ABC1 family protein 0.0036 0.0262 0.0294
Schistosoma mansoni hypothetical protein 0.002 0.006 0.0109
Loa Loa (eye worm) hypothetical protein 0.0049 0.0429 0.0502
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0128 0.0128
Onchocerca volvulus 0.004 0.0313 0.0273
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.002 0.0055 0.0051
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0396
Toxoplasma gondii hypothetical protein 0.0026 0.0135 0.0145
Schistosoma mansoni cpg binding protein 0.0066 0.064 0.1163
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0562 0.0645
Echinococcus granulosus intermediate filament protein 0.0027 0.0149 0.0271
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0262 0.0294
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0087 0.0911 0.1653
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0799 0.0799
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0068 0.0124
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Leishmania major farnesyltransferase beta subunit 0.002 0.0055 0.0051
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.004 0.0313 0.0313
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0818 0.1484
Leishmania major lanosterol synthase, putative 0.0125 0.14 0.1627
Brugia malayi nuclear hormone receptor 0.0038 0.0281 0.0329
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0368 0.0431
Trypanosoma cruzi phospholipase A2-like protein, putative 0.015 0.1719 0.2001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0818 0.0818
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0307
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0087 0.0911 0.1066
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.2826 0.2826
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0911 0.1066
Plasmodium vivax importin-beta 2, putative 0.0029 0.017 0.0316
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Schistosoma mansoni hypothetical protein 0.0309 0.3739 0.6787
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0685 0.8545 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0799 0.145
Schistosoma mansoni nAChR subunit 0.0087 0.0911 0.1653
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0114 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-40 0.008 0.0818 0.0957
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0251 0.0251
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0368 0.0368
Onchocerca volvulus 0.0038 0.0281 0.0219
Echinococcus multilocularis snurportin 1 0.0309 0.3739 0.3739
Schistosoma mansoni nAChR subunit 0.0087 0.0911 0.1653
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0135 0.0916
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Brugia malayi ecdysteroid receptor 0.008 0.0818 0.0957
Brugia malayi CXXC zinc finger family protein 0.006 0.0573 0.067
Loa Loa (eye worm) LGC-31 protein 0.0087 0.0911 0.1066
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.077 0.5723
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.077 0.0889
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0281 0.0281
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.077 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0818 0.0957
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0562 0.0645
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0055 0.0087
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0396
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0911 0.1653
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Loa Loa (eye worm) hypothetical protein 0.0498 0.6157 0.7205
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Echinococcus granulosus cpg binding protein 0.0066 0.064 0.1163
Schistosoma mansoni hypothetical protein 0.0185 0.2166 0.3932
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0262 0.0498
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0011 0.002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0593 0.1076
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0087 0.0911 0.1066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0399 0.0725
Echinococcus multilocularis dnaJ subfamily B 0.0447 0.5509 0.5509
Mycobacterium leprae Probable lipase LipE 0.0036 0.0262 0.1876
Echinococcus multilocularis musashi 0.0027 0.0149 0.0149
Schistosoma mansoni retinoic acid receptor RXR 0.008 0.0818 0.1484
Loa Loa (eye worm) acetylcholine receptor protein 0.004 0.0313 0.0367
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0055 0.01
Brugia malayi Bromodomain containing protein 0.0038 0.0281 0.0329
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0087 0.0911 0.1653
Plasmodium vivax glutathione reductase, putative 0.0047 0.0406 0.0785
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.077 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0911 0.0911
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0911 0.1653
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0015 0.0015
Mycobacterium tuberculosis Probable reductase 0.0108 0.1181 0.2923
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0429 0.0502
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0116 0.1287 0.1506
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0281 0.051
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0021 0.0021
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0128 0.0232
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0685 0.8545 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0262 0.0627
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0585 0.0672
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0436 0.3196
Onchocerca volvulus 0.004 0.0313 0.0273
Loa Loa (eye worm) beta-lactamase 0.0036 0.0262 0.0307
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Schistosoma mansoni hypothetical protein 0.0185 0.2166 0.3932
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.008 0.0818 0.1484
Schistosoma mansoni hypothetical protein 0.0447 0.5509 1
Schistosoma mansoni ran 0.0021 0.0073 0.0133
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0911 0.1066
Entamoeba histolytica hypothetical protein 0.0047 0.0399 0.0405
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0368 0.0668
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0087 0.0911 0.1653
Schistosoma mansoni coup transcription factor 0.008 0.0818 0.1484
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0055 0.0051
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.008 0.0818 0.1484
Trichomonas vaginalis esterase, putative 0.0036 0.0262 0.0294
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0087 0.0911 0.1066
Trypanosoma cruzi protein farnesyltransferase, putative 0.002 0.0055 0.0051
Echinococcus granulosus geminin 0.0185 0.2166 0.3932
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.2744 0.6826
Onchocerca volvulus 0.0047 0.0399 0.0416
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0123
Echinococcus granulosus dnaJ subfamily B 0.0447 0.5509 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0281 0.051
Onchocerca volvulus 0.0087 0.0911 0.1268
Onchocerca volvulus 0.008 0.0818 0.1113
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0262 0.0627
Brugia malayi Cation transporter family protein 0.0087 0.0911 0.1066
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.1181 0.2923
Schistosoma mansoni acetylcholine receptor subunit beta 0.004 0.0313 0.0569
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0368 0.0668
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.002 0.0055 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0114 0.0133
Onchocerca volvulus Phospholipase A2 homolog 0.0091 0.0959 0.1348
Schistosoma mansoni thyroid hormone receptor 0.008 0.0818 0.1484
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0262 0.0307
Schistosoma mansoni hypothetical protein 0.0048 0.0419 0.076
Brugia malayi PHD-finger family protein 0.0028 0.0157 0.0184
Onchocerca volvulus 0.0328 0.3983 0.6382
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.008 0.0818 0.1113
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0365
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0055 0.0051
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0128 0.0232
Mycobacterium ulcerans epoxide hydrolase EphA 0.033 0.4014 0.469
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0262 0.0627
Onchocerca volvulus 0.0087 0.0911 0.1268
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.1181 0.2923
Trypanosoma cruzi phospholipase A1, putative 0.0328 0.3983 0.4654
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0281 0.0281
Echinococcus granulosus snurportin 1 0.0309 0.3739 0.6787
Loa Loa (eye worm) hypothetical protein 0.0034 0.023 0.0269
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0281 0.0281
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0251 0.0456
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0073 0.0072
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0411 0.5047 0.5901
Leishmania major phospholipase A1, putative 0.0328 0.3983 0.4654
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Schistosoma mansoni steroid hormone receptor ad4bp 0.008 0.0818 0.1484
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0087 0.0911 0.1066
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0411 0.5047 0.5901
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Loa Loa (eye worm) GABA receptor subunit 0.0047 0.0399 0.0467
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0685 0.8545 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0419 0.076
Schistosoma mansoni lamin 0.0027 0.0149 0.0271
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.008 0.0818 0.0818
Brugia malayi Importin beta-1 subunit 0.0029 0.017 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0064
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0281 0.051
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0328 0.3983 0.4661
Loa Loa (eye worm) hypothetical protein 0.008 0.0818 0.0957
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.008 0.0818 0.0957
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0064
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0411 0.5047 0.5901
Echinococcus multilocularis FTZ F1 alpha 0.008 0.0818 0.0818
Echinococcus multilocularis lamin 0.0027 0.0149 0.0149
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.004 0.0313 0.0367
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0411 0.5047 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.008 0.0818 0.0957
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.2826 0.513
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0087 0.0911 0.1066
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0429 0.0502
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0911 0.0911
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0087 0.0911 0.1066
Loa Loa (eye worm) hypothetical protein 0.0091 0.0959 0.1122
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Mycobacterium tuberculosis Conserved protein 0.0036 0.0262 0.0627
Mycobacterium tuberculosis Probable oxidoreductase 0.0276 0.3317 0.826
Echinococcus granulosus zinc finger protein 0.0023 0.0091 0.0165
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0573 0.067
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0436 0.0792
Schistosoma mansoni nAChR subunit 0.0087 0.0911 0.1653
Echinococcus multilocularis geminin 0.0185 0.2166 0.2166
Loa Loa (eye worm) hypothetical protein 0.0116 0.1287 0.1506
Echinococcus multilocularis ecdysone induced protein 78C 0.008 0.0818 0.0818
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.1181 0.2923
Echinococcus granulosus importin subunit beta 1 0.0029 0.017 0.0309
Brugia malayi nuclear hormone receptor 0.008 0.0818 0.0957
Loa Loa (eye worm) integrin alpha pat-2 0.0237 0.2828 0.3309
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.017 0.0187
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.002 0.0055 0.01
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Echinococcus multilocularis synaptic glycoprotein sc2 0.0411 0.5047 0.5047
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Schistosoma mansoni bromodomain containing protein 0.0066 0.0638 0.1158
Echinococcus granulosus nAChR subunit 0.0087 0.0911 0.1653
Schistosoma mansoni nuclear receptor 0.0038 0.0281 0.051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0593 0.0593
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0818 0.0957
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0101 0.0105
Echinococcus granulosus integrin alpha ps 0.0033 0.0224 0.0406
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0089 0.0104
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0262 0.0627
Loa Loa (eye worm) hypothetical protein 0.0069 0.0687 0.0804
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.0338 0.0614
Brugia malayi Thioredoxin reductase 0.0047 0.0406 0.0476
Onchocerca volvulus 0.0156 0.1787 0.2727
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0562 0.0645
Echinococcus granulosus lamin dm0 0.0027 0.0149 0.0271
Schistosoma mansoni importin beta-1 0.0029 0.017 0.0309
Loa Loa (eye worm) hypothetical protein 0.0045 0.0379 0.0444
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.002 0.0055 0.0055
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.004 0.0313 0.0367
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1303 0.1525
Schistosoma mansoni integrin alpha-ps 0.0036 0.026 0.0472
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0262 0.0294
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0281 0.0329
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0055 0.0051
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0307
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0149 0.0175
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Entamoeba histolytica hypothetical protein 0.0411 0.5047 0.588
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Onchocerca volvulus 0.0087 0.0911 0.1268
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0047 0.0399 0.0467
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0262 0.0262
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0411 0.5047 0.5901
Onchocerca volvulus Bile acid receptor homolog 0.008 0.0818 0.1113
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0911 0.1066
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.017 0.0187
Schistosoma mansoni nuclear receptor 0.0038 0.0281 0.051
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0299 0.3621 0.4237
Plasmodium vivax farnesyltransferase beta subunit, putative 0.002 0.0055 0.0087
Trypanosoma brucei protein farnesyltransferase beta subunit 0.002 0.0055 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0368 0.0668
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0396
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.0818 0.0957
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.002 0.0055 0.0055
Brugia malayi RNA, U transporter 1 0.0082 0.085 0.0995
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0585 0.0585
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0281 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0818 0.0957
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0911 0.1066
Echinococcus granulosus retinoic acid receptor rxr beta a 0.008 0.0818 0.1484
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0685 0.8545 1
Echinococcus multilocularis integrin alpha ps 0.0033 0.0224 0.0224
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.004 0.0313 0.0569
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0073 0.0133
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.002 0.0055 0.0051
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1335 0.3308
Brugia malayi nuclear receptor NHR-88 0.0038 0.0281 0.0329
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0299 0.3621 0.6573
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0299 0.3621 0.6573
Echinococcus multilocularis cpg binding protein 0.0066 0.064 0.064
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.0818 0.1484
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0262 0.0294
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0307
Loa Loa (eye worm) hypothetical protein 0.0156 0.1787 0.2092
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0411 0.5047 0.5047
Giardia lamblia Synaptic glycoprotein SC2 0.0411 0.5047 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0087 0.0911 0.1066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.008 0.0818 0.0957
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.004 0.0313 0.0367
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.054 0.098
Echinococcus multilocularis integrin alpha ps 0.0069 0.0682 0.0682
Brugia malayi nuclear receptor NHR-88 0.008 0.0818 0.0957
Brugia malayi Cation transporter family protein 0.0087 0.0911 0.1066
Onchocerca volvulus Phospholipase A2 homolog 0.0498 0.6157 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.2701 0.3161
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0055 0.0051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.1465 0.266
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.008 0.0818 0.1484
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.002 0.0055 0.0051
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0313 0.0569
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0436 0.0436
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0047 0.0399 0.0467
Plasmodium falciparum thioredoxin reductase 0.0047 0.0406 0.0785
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0411 0.5047 0.5901
Onchocerca volvulus 0.0156 0.1787 0.2727
Brugia malayi MH2 domain containing protein 0.0118 0.1303 0.1525
Schistosoma mansoni thyroid hormone receptor 0.008 0.0818 0.1484
Echinococcus multilocularis nAChR subunit 0.0087 0.0911 0.0911
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0262 0.0307
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0262 0.0294
Mycobacterium tuberculosis Conserved protein 0.0036 0.0262 0.0627
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0411 0.5047 0.5901
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0087 0.0911 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.008 0.0818 0.0957
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.0338 0.0396
Brugia malayi photoreceptor-specific nuclear receptor 0.008 0.0818 0.0957
Onchocerca volvulus 0.0036 0.0262 0.0188
Onchocerca volvulus 0.0328 0.3983 0.6382
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0262 0.0627
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0585 0.1062
Loa Loa (eye worm) hypothetical protein 0.0047 0.0399 0.0467
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0299 0.3621 0.6573
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0073 0.0072
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0281 0.051
Loa Loa (eye worm) steroid hormone receptor 0.008 0.0818 0.0957
Loa Loa (eye worm) PHD-finger family protein 0.002 0.006 0.007
Brugia malayi nuclear receptor RXR 0.0038 0.0281 0.0329
Echinococcus granulosus ecdysone induced protein 78C 0.008 0.0818 0.1484
Schistosoma mansoni nuclear hormone receptor 0.008 0.0818 0.1484
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.008 0.0818 0.1484
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.1181 0.2923
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.002 0.0055 0.01
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0087 0.0911 0.1066
Loa Loa (eye worm) hypothetical protein 0.0047 0.0399 0.0467
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.077 1
Brugia malayi Bromodomain containing protein 0.0077 0.0784 0.0918
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0087 0.0911 0.1653
Onchocerca volvulus 0.0328 0.3983 0.6382
Brugia malayi hypothetical protein 0.0237 0.2826 0.3307
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0685 0.8545 1
Toxoplasma gondii thioredoxin reductase 0.0047 0.0406 0.0463
Echinococcus multilocularis importin subunit beta 1 0.0029 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0033 0.0224 0.0406
Mycobacterium ulcerans short chain dehydrogenase 0.0276 0.3317 0.3874
Echinococcus multilocularis integrin alpha 3 0.0118 0.1307 0.1307
Loa Loa (eye worm) hypothetical protein 0.008 0.0818 0.0957
Brugia malayi hypothetical protein 0.0038 0.0281 0.0329
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0299 0.3621 0.3621
Trypanosoma cruzi lanosterol synthase, putative 0.0145 0.1653 0.1924
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0167
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0281 0.0329
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.008 0.0826 0.2037
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.008 0.0818 0.1484
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0406 0.0463
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.077 0.077
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0799 0.145
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0299 0.3621 0.3621
Brugia malayi hypothetical protein 0.0016 0.0003 0.0004
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.077 0.0889
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0055 0.0064
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0047 0.0399 0.0467
Mycobacterium ulcerans short chain dehydrogenase 0.0017 0.0014 0.0004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.132 0.1534
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.002 0.0055 0.0051
Loa Loa (eye worm) ACC-1 protein 0.0087 0.0911 0.1066
Onchocerca volvulus 0.0061 0.0585 0.0725
Brugia malayi ecdysone receptor 0.0038 0.0281 0.0329
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0087 0.0911 0.1653
Brugia malayi tailless protein 0.0038 0.0281 0.0329
Trichomonas vaginalis set domain proteins, putative 0.0478 0.5902 0.6902
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.008 0.0818 0.0818
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0406 0.0738
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0017 0.0014 0.0008
Leishmania major hypothetical protein, conserved 0.0024 0.0114 0.012
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0911 0.1653
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0281 0.051
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0396
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0262 0.0294
Schistosoma mansoni nAChR subunit 0.0087 0.0911 0.1653
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0047 0.0399 0.0725
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.042 0.5163 0.6042
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0911 0.1066
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0411 0.5047 0.588
Plasmodium falciparum polyprenol reductase, putative 0.0411 0.5047 1
Trypanosoma cruzi phospholipase A2-like protein, putative 0.015 0.1719 0.2001
Giardia lamblia Prenyltransferase 0.002 0.0055 0.0087
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0299 0.3621 0.3621
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Onchocerca volvulus 0.0036 0.0262 0.0188
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.008 0.0818 0.1484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0585 0.1062
Brugia malayi hypothetical protein 0.0038 0.0281 0.0329
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0114 0.012
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0114 0.012
Loa Loa (eye worm) hypothetical protein 0.008 0.0818 0.0957
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0911 0.1066
Onchocerca volvulus 0.0047 0.0399 0.0416
Echinococcus multilocularis zinc finger protein 0.0023 0.0091 0.0091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0368 0.0368
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.077 1
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0338 0.0396
Mycobacterium ulcerans hypothetical protein 0.0036 0.0262 0.0294
Onchocerca volvulus 0.006 0.0573 0.0705
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0406 0.0476
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.004 0.0313 0.0569
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0685 0.8545 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0799 0.145
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Plasmodium vivax geranylgeranyltransferase, putative 0.002 0.0055 0.0087
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0396
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0281 0.0329
Echinococcus granulosus integrin alpha ps 0.0069 0.0682 0.1238
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0281 0.051
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.002 0.0055 0.0064
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0911 0.1653
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0021 0.0039
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.004 0.0313 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0818 0.0957
Brugia malayi Synaptic glycoprotein SC2 0.0411 0.5047 0.5907
Schistosoma mansoni lamin 0.0027 0.0149 0.0271
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0281 0.051
Brugia malayi hypothetical protein 0.004 0.0313 0.0367
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.002 0.0055 0.0051
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0562 0.0645
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0047 0.0399 0.0467
Echinococcus multilocularis lamin dm0 0.0027 0.0149 0.0149
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.3739 0.4375
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0685 0.8545 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0087 0.0911 0.0911
Brugia malayi Integrin alpha pat-2 precursor 0.0154 0.1765 0.2065
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0281 0.051
Trypanosoma cruzi protein farnesyltransferase, putative 0.002 0.0055 0.0051
Loa Loa (eye worm) hypothetical protein 0.0411 0.5047 0.5907
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0087 0.0911 0.0911
Leishmania major geranylgeranyltransferase, putative 0.002 0.0055 0.0051
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0562 0.102
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0262 0.0476
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0055 0.0064
Onchocerca volvulus 0.0411 0.5047 0.8154
Mycobacterium ulcerans beta-lactamase 0.0036 0.0262 0.0294
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0411 0.5047 0.5901
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0338 0.0396
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0281 0.0219
Plasmodium vivax SET domain protein, putative 0.0061 0.0585 0.114
Loa Loa (eye worm) hypothetical protein 0.008 0.0818 0.0957
Schistosoma mansoni integrin alpha 0.0154 0.1765 0.3204
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0429 0.0502
Onchocerca volvulus Putative nachr subunit 0.0299 0.3621 0.5779
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0262 0.0294
Schistosoma mansoni zinc finger protein 0.0023 0.0091 0.0165
Brugia malayi conserved hypotetical protein 0.0038 0.0281 0.0329
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Brugia malayi Phospholipase A2 family protein 0.0498 0.6157 0.7205
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0281 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.008 0.0818 0.0957
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0313 0.0367
Schistosoma mansoni acetylcholine receptor-related 0.004 0.0313 0.0569
Schistosoma mansoni cpg binding protein 0.0066 0.064 0.1163
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0281 0.0329
Brugia malayi hypothetical protein 0.004 0.0313 0.0367
Echinococcus multilocularis nAChR subunit 0.0047 0.0399 0.0399
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0419 0.049
Plasmodium falciparum glutathione reductase 0.0047 0.0406 0.0785
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0818 0.0818
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0015 0.0027
Mycobacterium tuberculosis Conserved protein 0.0036 0.0262 0.0627
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.008 0.0818 0.0957
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.008 0.0818 0.1484
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.002 0.0055 0.0087
Brugia malayi excitatory GABA receptor EXP-1A 0.0087 0.0911 0.1066
Leishmania major importin beta-1 subunit, putative 0.0023 0.0101 0.0105
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Trichomonas vaginalis ran, putative 0.0021 0.0073 0.0072
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.004 0.0313 0.0313
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0411 0.5047 0.9163
Echinococcus granulosus integrin alpha 3 0.0118 0.1307 0.2372
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0262 0.0627
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0262 0.0476
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0199
Brugia malayi Pre-SET motif family protein 0.042 0.5163 0.6042
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0911 0.1653
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0562 0.0645
Schistosoma mansoni RAR-like nuclear receptor 0.008 0.0818 0.1484
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Echinococcus multilocularis integrin alpha ps 0.0069 0.0682 0.0682
Echinococcus granulosus FTZ F1 alpha 0.008 0.0818 0.1484
Brugia malayi intermediate filament protein 0.0027 0.0149 0.0175
Onchocerca volvulus 0.0038 0.0281 0.0219
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Loa Loa (eye worm) hypothetical protein 0.0047 0.0399 0.0467
Onchocerca volvulus 0.0478 0.5902 0.9576
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0262 0.0294
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.002 0.0055 0.0051
Plasmodium vivax polyprenol reductase, putative 0.0411 0.5047 1
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.002 0.0055 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Giardia lamblia Rab geranylgeranyltransferase 0.002 0.0055 0.0087
Onchocerca volvulus 0.0036 0.0262 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-31 0.008 0.0818 0.0957
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0685 0.8545 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.077 0.1507
Loa Loa (eye worm) hypothetical protein 0.0085 0.0885 0.1035
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0068 0.008
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1303 0.1525
Loa Loa (eye worm) hypothetical protein 0.0047 0.0399 0.0467
Plasmodium falciparum protein farnesyltransferase subunit beta 0.002 0.0055 0.0087
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.077 0.1507
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0338 0.0614
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0262 0.0294
Brugia malayi Steroid receptor seven-up type 2 0.008 0.0818 0.0957
Schistosoma mansoni intermediate filament proteins 0.0027 0.0149 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-14 0.008 0.0818 0.0957
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.008 0.0818 0.0957
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0073 0.0072
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0281 0.0329
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0562 0.102
Brugia malayi Nuclear hormone receptor family member nhr-1 0.008 0.0818 0.0957
Echinococcus multilocularis glycine receptor subunit beta 0.0087 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-3 0.008 0.0818 0.0957
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0175
Loa Loa (eye worm) hypothetical protein 0.0076 0.077 0.0901
Schistosoma mansoni nAChR subunit 0.004 0.0313 0.0569
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0135 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0368 0.0668
Schistosoma mansoni nAChR subunit 0.0087 0.0911 0.1653
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0073 0.0072
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0911 0.1066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0282 0.033
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0149 0.0175
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.0338 0.0614
Loa Loa (eye worm) hypothetical protein 0.008 0.0818 0.0957
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0313 0.0367
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0685 0.8545 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.002 0.0055 0.0051
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.1181 0.8834
Brugia malayi hypothetical protein 0.004 0.0313 0.0367
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0818 0.1484
Loa Loa (eye worm) hypothetical protein 0.0116 0.1276 0.1493
Schistosoma mansoni nAChR subunit 0.0087 0.0911 0.1653
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0411 0.5047 0.588
Loa Loa (eye worm) hypothetical protein 0.0038 0.0281 0.0329
Brugia malayi hypothetical protein 0.0042 0.0338 0.0396
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0114 0.012
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.002 0.0055 0.0051
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0123
Loa Loa (eye worm) DR-78 0.0038 0.0281 0.0329
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0281 0.051
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0047 0.0399 0.0467
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0087 0.0911 0.0911
Mycobacterium ulcerans lipase LipD 0.0036 0.0262 0.0294
Trypanosoma brucei phospholipase A1, putative 0.0328 0.3983 0.4654
Loa Loa (eye worm) hypothetical protein 0.0078 0.0799 0.0934
Onchocerca volvulus 0.004 0.0313 0.0273
Mycobacterium ulcerans hypothetical protein 0.0685 0.8545 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0262 0.0294
Echinococcus granulosus glycine receptor subunit beta 0.0087 0.0911 0.1653
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.017 0.0187
Trypanosoma brucei lanosterol synthase 0.0145 0.1653 0.1924
Echinococcus granulosus synaptic glycoprotein sc2 0.0411 0.5047 0.9163
Schistosoma mansoni nAChR subunit 0.004 0.0313 0.0569
Brugia malayi glutathione reductase 0.0047 0.0406 0.0476
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.008 0.0818 0.0818
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0021 0.0039
Loa Loa (eye worm) hypothetical protein 0.0087 0.0911 0.1066
Schistosoma mansoni integrin alpha-ps 0.0069 0.0682 0.1238
Loa Loa (eye worm) hypothetical protein 0.0411 0.5047 0.5907
Trichomonas vaginalis conserved hypothetical protein 0.0411 0.5047 0.5901
Brugia malayi follicle stimulating hormone receptor 0.0227 0.2701 0.3161
Trypanosoma cruzi phospholipase A1, putative 0.0328 0.3983 0.4654
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.023 0.0269
Brugia malayi Pre-SET motif family protein 0.0061 0.0585 0.0685
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0011 0.002
Brugia malayi beta-lactamase 0.0036 0.0262 0.0307
Loa Loa (eye worm) ACC-1 protein 0.0087 0.0911 0.1066
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0135 0.0246
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0281 0.0329
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0299 0.3621 0.4237
Entamoeba histolytica hypothetical protein 0.0023 0.0101 0.0054
Brugia malayi nuclear receptor RXR 0.0042 0.0338 0.0396
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0085
Loa Loa (eye worm) hypothetical protein 0.0047 0.0399 0.0467
Loa Loa (eye worm) hypothetical protein 0.008 0.0818 0.0957
Schistosoma mansoni cpg binding protein 0.006 0.0573 0.1039
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0114 0.012
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0313 0.0367
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0281 0.051
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.008 0.0818 0.0818
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.008 0.0818 0.1484
Brugia malayi Probable ClpP-like protease 0.0076 0.077 0.0901
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0149 0.0175
Echinococcus granulosus lamin 0.0027 0.0149 0.0271
Loa Loa (eye worm) hypothetical protein 0.008 0.0818 0.0957
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0262 0.0476
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0436 0.1062
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0087 0.0911 0.1066
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.077 0.1398
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0262 0.0294
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0281 0.0281
Leishmania major hypothetical protein, conserved 0.0036 0.0262 0.0294
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0411 0.5047 0.9163
Loa Loa (eye worm) hypothetical protein 0.0685 0.8545 1
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0055 0.0051
Loa Loa (eye worm) hypothetical protein 0.0047 0.0399 0.0467
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0021 0.0039
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0015 0.0027
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0068 0.0068
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1335 0.3308
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0818 0.0957
Loa Loa (eye worm) hypothetical protein 0.0121 0.1343 0.1572
Loa Loa (eye worm) hypothetical protein 0.004 0.0313 0.0367
Leishmania major trypanothione reductase 0.0047 0.0406 0.0463
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0262 0.0627
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0436 0.1062
Loa Loa (eye worm) hypothetical protein 0.0036 0.026 0.0304
Loa Loa (eye worm) glutathione reductase 0.0047 0.0406 0.0476
Schistosoma mansoni Tr4/Tr2 (homologue) 0.008 0.0818 0.1484
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.002 0.0055 0.0051
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0087 0.0911 0.1653
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0073 0.0085
Brugia malayi hypothetical protein 0.004 0.0313 0.0367
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0087 0.0911 0.1066
Plasmodium falciparum geranylgeranyltransferase, putative 0.002 0.0055 0.0087
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0406 0.0987
Brugia malayi Cation transporter family protein 0.0156 0.1787 0.2092
Brugia malayi hypothetical protein 0.0024 0.0114 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0399 0.0467
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0911 0.1066
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0313 0.0569
Brugia malayi nuclear receptor NHR-67 0.0038 0.0281 0.0329
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0281 0.0219
Trypanosoma brucei trypanothione reductase 0.0047 0.0406 0.0463
Brugia malayi beta-lactamase family protein 0.0036 0.0262 0.0307

Activities

Activity type Activity value Assay description Source Reference
Degree of activation (functional) = 19 fold Ratio of the IC50 of the compound in thebeta-Gal- and CPG2-expressing cell line ChEMBL. 15115406
Degree of activation (functional) = 19 fold Ratio of the IC50 of the compound in thebeta-Gal- and CPG2-expressing cell line ChEMBL. 15115406
IC50 (functional) = 165 uM Cytotoxicity in the line MDA MB 361 breast adenocarcinoma cell line expressing bata-galactosidase ChEMBL. 15115406
IC50 (functional) = 165 uM Cytotoxicity in the line MDA MB 361 breast adenocarcinoma cell line expressing bata-galactosidase ChEMBL. 15115406
IC50 (functional) = 3125 uM Cytotoxicity in the line MDA MB 361 breast adenocarcinoma cell line expressing CPG2 ChEMBL. 15115406
IC50 (functional) = 3125 uM Cytotoxicity in the line MDA MB 361 breast adenocarcinoma cell line expressing CPG2 ChEMBL. 15115406
T1/2 (ADMET) = 59 min The chemical half-life of the compound was determined by HPLC ChEMBL. 15115406

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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