Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | pyruvate kinase, muscle | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyruvate kinase | pyruvate kinase, muscle | 605 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.004 | 0.8988 | 0.8988 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0005 | 0.0005 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.004 | 0.8988 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0005 | 0.0005 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.6273 | 0.6271 |
Schistosoma mansoni | pyruvate kinase | 0.0021 | 0.2715 | 0.2712 |
Leishmania major | pyruvate kinase | 0.004 | 0.8988 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0005 | 0.0005 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.8988 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.004 | 0.8988 | 0.8988 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.8988 | 0.8988 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0005 | 0.0005 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0005 | 0.0005 |
Plasmodium vivax | pyruvate kinase, putative | 0.004 | 0.8988 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0005 | 0.0005 |
Leishmania major | pyruvate kinase | 0.004 | 0.8988 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0021 | 0.2715 | 0.2712 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 0.8988 | 0.8988 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.0005 | 0.0005 |
Echinococcus multilocularis | pyruvate kinase | 0.0021 | 0.2715 | 0.2712 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0005 | 0.0005 |
Chlamydia trachomatis | pyruvate kinase | 0.004 | 0.8988 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0021 | 0.2715 | 0.2712 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0005 | 0.0005 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0005 | 0.0005 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.004 | 0.8988 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.004 | 0.8988 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0005 | 0.0005 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0028 | 0.5089 | 0.5659 |
Mycobacterium ulcerans | pyruvate kinase | 0.004 | 0.8988 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.8988 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1 | 0.004 | 0.8988 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0005 | 0.0005 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.0005 | 0.0005 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0005 | 0.0005 |
Echinococcus granulosus | pyruvate kinase | 0.0021 | 0.2715 | 0.2712 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.8988 | 0.8988 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.8988 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.5089 | 0.5659 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.8988 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.004 | 0.8988 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.004 | 0.8988 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.8988 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.8988 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.8988 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.8988 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.0005 | 0.0005 |
Echinococcus granulosus | pyruvate kinase | 0.0021 | 0.2715 | 0.2712 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.8988 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0005 | 0.0005 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.8988 | 0.8988 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0005 | 0.0005 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.0005 | 0.0005 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0021 | 0.2715 | 0.2712 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.8988 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.8988 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 0.8988 | 0.8988 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.004 | 0.8988 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.8988 | 0.8988 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.