Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0138 | 0.7152 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0769 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0253 | 0.0354 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.2989 | 0.2807 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0769 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0138 | 0.7152 | 0.7078 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0138 | 0.7152 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0138 | 0.7152 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0138 | 0.7152 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0769 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0138 | 0.7152 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0253 | 0.0354 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0188 | 1 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.2989 | 0.4179 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0769 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2989 | 0.4179 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2151 | 0.1947 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2989 | 0.4179 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2151 | 0.1947 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0138 | 0.7152 | 0.7078 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0138 | 0.7152 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0275 | 0.0022 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0769 | 0.0529 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0138 | 0.7152 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0253 | 0.0354 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0253 | 0.0354 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.2989 | 0.2807 |
Brugia malayi | RNA binding protein | 0.0064 | 0.2989 | 0.2807 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0769 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.2989 | 0.2807 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0253 | 0.0354 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1272 | 0.1046 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2151 | 0.1947 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2989 | 0.4179 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0253 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2989 | 0.4179 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2151 | 0.1947 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0769 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0769 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.2989 | 0.2807 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0769 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0253 | 0.0354 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0253 | 0.0354 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0253 | 0.0354 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.2989 | 0.4179 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2989 | 0.4179 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0769 | 0.0529 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1272 | 0.1779 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1272 | 0.1046 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0253 | 0.0354 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.2989 | 0.2807 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 63.0957 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.