Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0088 | 0.674 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.4661 | 0.4661 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.2419 | 0.2419 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2419 | 0.519 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.4661 | 0.4661 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4661 | 0.6916 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0338 | 0.0338 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0338 | 0.0501 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.2419 | 0.519 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.4661 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0338 | 0.0338 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4661 | 0.6916 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2441 | 0.5237 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0338 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.4138 | 0.8878 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0338 | 0.0501 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0338 | 0.0338 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.4661 | 0.4661 |
Brugia malayi | RNA binding protein | 0.0074 | 0.4661 | 0.4661 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.4661 | 0.4661 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.4661 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4661 | 0.6916 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.4661 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0338 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0878 | 0.0878 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0338 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0338 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4661 | 0.6916 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.2419 | 0.2419 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4661 | 0.6916 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.9285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.