Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutaminase | 0.0314 | 1 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0189 | 0.5367 | 0.5367 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.566 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | glutaminase | 0.0314 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.566 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.566 | 0.566 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.566 | 0.566 |
Loa Loa (eye worm) | glutaminase 2 | 0.0314 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.1175 | 0.1175 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.5367 | 0.5367 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.5367 | 0.5367 |
Onchocerca volvulus | 0.0114 | 0.2593 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0189 | 0.5367 | 0.5367 |
Loa Loa (eye worm) | glutaminase | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2466 | 0.2466 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.566 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.1175 | 0.1175 |
Echinococcus granulosus | tar DNA binding protein | 0.0189 | 0.5367 | 0.9483 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.5367 | 0.5367 |
Loa Loa (eye worm) | RNA binding protein | 0.0189 | 0.5367 | 0.5367 |
Brugia malayi | RNA binding protein | 0.0189 | 0.5367 | 0.5367 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.011 | 0.2466 | 0.2466 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.4647 | 0.4647 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.5367 | 0.5367 |
Trichomonas vaginalis | glutaminase, putative | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0189 | 0.5367 | 0.5367 |
Trypanosoma brucei | glucosidase, putative | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.011 | 0.2466 | 0.2466 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0044 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0189 | 0.5367 | 0.5367 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.4647 | 0.4647 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.5367 | 0.5367 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.011 | 0.2466 | 0.2466 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1175 | 0.1175 |
Echinococcus multilocularis | tar DNA binding protein | 0.0189 | 0.5367 | 0.9483 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.6511 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 25.4639 uM | PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.