Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0216 | 0.5042 | 0.5042 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.2177 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.2177 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.1057 | 0.1057 |
Brugia malayi | RNA recognition motif domain containing protein | 0.033 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.2177 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.9386 | 0.9386 |
Brugia malayi | hypothetical protein | 0.015 | 0.2177 | 0.2177 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.015 | 0.2177 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.033 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.1057 | 0.1057 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0316 | 0.9386 | 0.9386 |
Brugia malayi | TAR-binding protein | 0.033 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.033 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.015 | 0.2177 | 0.2177 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.015 | 0.2177 | 0.2177 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.1057 | 0.1057 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0316 | 0.9386 | 0.9386 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0316 | 0.9386 | 0.9386 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.2177 | 0.2177 |
Loa Loa (eye worm) | TAR-binding protein | 0.033 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.015 | 0.2177 | 0.2177 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.033 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.5042 | 0.5042 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0216 | 0.5042 | 0.5042 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.033 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 79.22 % | Cytotoxicity against human T47D cells assessed as survival at 25 uM after 2 days by MTT assay | ChEMBL. | 20800481 |
IC50 (functional) | = 75 uM | Cytotoxicity against human T47D cells after 2 days by MTT assay | ChEMBL. | 20800481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.