Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0131 | 0.2893 | 0.2893 |
Brugia malayi | Smad1 | 0.0017 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0046 | 0.0046 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0289 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0044 | 0.0044 |
Schistosoma mansoni | tar DNA-binding protein | 0.0402 | 0.9736 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0017 | 0.0044 | 0.0045 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0131 | 0.2893 | 0.2893 |
Brugia malayi | TAR-binding protein | 0.0402 | 0.9736 | 0.9736 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.4146 | 0.4146 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0289 | 0.0289 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0289 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0017 | 0.0044 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.2893 | 0.2893 |
Schistosoma mansoni | smad | 0.0017 | 0.0044 | 0.0045 |
Schistosoma mansoni | tar DNA-binding protein | 0.0402 | 0.9736 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0402 | 0.9736 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0402 | 0.9736 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.4146 | 0.4259 |
Echinococcus multilocularis | tar DNA binding protein | 0.0402 | 0.9736 | 1 |
Echinococcus granulosus | smad | 0.0017 | 0.0044 | 0.0045 |
Echinococcus multilocularis | smad | 0.0017 | 0.0044 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4146 | 0.4146 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.2893 | 0.2971 |
Echinococcus multilocularis | Smad4 | 0.0017 | 0.0044 | 0.0045 |
Echinococcus multilocularis | GPCR, family 2 | 0.0131 | 0.2893 | 0.2971 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0131 | 0.2893 | 0.2971 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0289 | 1 |
Echinococcus granulosus | Smad4 | 0.0017 | 0.0044 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.6711 | 0.6711 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0289 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0017 | 0.0044 | 0.0044 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0044 | 0.0045 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.4146 | 0.4259 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4146 | 0.4146 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0017 | 0.0044 | 0.0045 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0289 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.2893 | 0.2971 |
Echinococcus granulosus | GPCR family 2 | 0.0131 | 0.2893 | 0.2971 |
Brugia malayi | RNA binding protein | 0.0402 | 0.9736 | 0.9736 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.2893 | 0.2971 |
Schistosoma mansoni | tar DNA-binding protein | 0.0402 | 0.9736 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0402 | 0.9736 | 0.9736 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0402 | 0.9736 | 0.9736 |
Echinococcus granulosus | tar DNA binding protein | 0.0402 | 0.9736 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0402 | 0.9736 | 0.9736 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0017 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | Smad1 | 0.0017 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0257 | 0.6065 | 0.6065 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.2893 | 0.2971 |
Schistosoma mansoni | Smad4 | 0.0017 | 0.0044 | 0.0045 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0402 | 0.9736 | 0.9736 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0289 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0044 | 0.0044 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0044 | 0.0044 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0131 | 0.2893 | 0.2971 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0257 | 0.6065 | 0.6065 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0289 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0131 | 0.2893 | 0.2893 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0131 | 0.2893 | 0.2971 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0017 | 0.0044 | 0.0045 |
Brugia malayi | MH2 domain containing protein | 0.0257 | 0.6065 | 0.6065 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0282 | 0.6711 | 0.6711 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0044 | 0.0045 |
Schistosoma mansoni | hypothetical protein | 0.0282 | 0.6711 | 0.6892 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0017 | 0.0044 | 0.0045 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0044 | 0.0045 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0131 | 0.2893 | 0.2971 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.4146 | 0.4259 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 11.2202 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.