TDR Targets

Basic information

Technical information

TDR Targets ID: 145777
Name: 6-[(2,3-dichloro-4,6-disulfamoylphenyl)carbam oyl]pyridine-2-carboxylic acid
MW: 469.277 | Formula: C13H10Cl2N4O7S2
H donors: 4 H acceptors: 8 LogP: 0.82 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cccc(n1)C(=O)O)Nc1c(Cl)c(Cl)c(cc1S(=O)(=O)N)S(=O)(=O)N
InChi: 1S/C13H10Cl2N4O7S2/c14-9-7(27(16,23)24)4-8(28(17,25)26)11(10(9)15)19-12(20)5-2-1-3-6(18-5)13(21)22/h1-4H,(H,19,20)(H,21,22)(H2,16,23,24)(H2,17,25,26)
InChiKey: IVKDUEUEOMQWRK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[(2,3-dichloro-4,6-disulfamoyl-phenyl)carbamoyl]pyridine-2-carboxylic acid
6-[(2,3-dichloro-4,6-disulfamoylanilino)-oxomethyl]-2-pyridinecarboxylic acid
6-[(2,3-dichloro-4,6-disulfamoyl-phenyl)carbamoyl]picolinic acid
6-[[(2,3-dichloro-4,6-disulfamoylphenyl)amino]-oxomethyl]-2-pyridinecarboxylic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	carbonic anhydrase II	Starlite/ChEMBL	References
Bos taurus	Carbonic anhydrase IV	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase I	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania mexicana	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei gambiense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	carbonic anhydrase 3	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania donovani	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Putative carbonic anhydrase 5 precursor	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus granulosus	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania braziliensis	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania major	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus multilocularis	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania infantum	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Carbonic anhydrase IV	312 aa	252 aa	23.4 %
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Carbonic anhydrase IV	312 aa	253 aa	26.9 %
Trypanosoma brucei	carbonic anhydrase-like protein	carbonic anhydrase I	261 aa	281 aa	25.3 %
Leishmania mexicana	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	287 aa	26.8 %
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Carbonic anhydrase IV	312 aa	322 aa	28.3 %
Leishmania braziliensis	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	277 aa	25.6 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase II	260 aa	259 aa	32.0 %
Schistosoma mansoni	carbonic anhydrase-related	Carbonic anhydrase IV	312 aa	265 aa	26.0 %
Echinococcus multilocularis	carbonic anhydrase	Carbonic anhydrase IV	312 aa	259 aa	30.1 %
Leishmania infantum	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	277 aa	26.7 %
Loa Loa (eye worm)	hypothetical protein	Carbonic anhydrase IV	312 aa	268 aa	25.4 %
Schistosoma mansoni	carbonic anhydrase-related	Carbonic anhydrase IV	312 aa	264 aa	24.2 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	Carbonic anhydrase IV	312 aa	268 aa	24.6 %
Echinococcus granulosus	carbonic anhydrase	Carbonic anhydrase IV	312 aa	304 aa	29.6 %
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Carbonic anhydrase IV	312 aa	264 aa	25.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0023	0	0.5
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 14	0.0023	0	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0082	0.0082
Schistosoma mansoni	hypothetical protein	0.0034	0.0082	0.0082
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0058	0.0267	0.0267
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0374	0.0374
Echinococcus multilocularis	Smad4	0.0034	0.0086	0.0086
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0058	0.0267	0.0267
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0058	0.0267	1
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0214	0.1435	0.1435
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.0584	0.0584
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0058	0.0267	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.1358	1	1
Loa Loa (eye worm)	hypothetical protein	0.0379	0.2666	0.2666
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0023	0	0.5
Brugia malayi	RNA binding protein	0.0543	0.3898	0.3898
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.1358	1	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.0584	0.0584
Brugia malayi	Pax transcription factor protein 2	0.0259	0.1766	0.1766
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0214	0.1435	0.1435
Onchocerca volvulus		0.0058	0.0267	0.1003
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0058	0.0267	0.0267
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0214	0.1435	0.1435
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0058	0.0267	0.0267
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0058	0.0267	1
Echinococcus multilocularis	expressed protein	0.0058	0.0267	0.0267
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0058	0.0267	0.0267
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0082	0.0082
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0058	0.0267	1
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0058	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0162	0.1043	0.1043
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.0086	0.0086
Schistosoma mansoni	smad	0.0034	0.0086	0.0086
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0058	0.0267	0.0267
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0058	0.0267	0.0267
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0058	0.0267	0.0267
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0584	0.0584
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0058	0.0267	0.0267
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.0625	0.0625
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0073	0.0375	0.0375
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0058	0.0267	0.0267
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0584	0.0584
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0584	0.0584
Loa Loa (eye worm)	TAR-binding protein	0.0543	0.3898	0.3898
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0584	0.0584
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.0625	0.0625
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0058	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0584	0.0584
Onchocerca volvulus		0.0259	0.1766	0.6626
Schistosoma mansoni	hypothetical protein	0.0034	0.0082	0.0082
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0034	0.0086	0.0086
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0214	0.1435	1
Brugia malayi	hypothetical protein	0.0058	0.0267	0.0267
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0584	0.0584
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0034	0.0086	0.0086
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0058	0.0267	0.0267
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0058	0.0267	0.0267
Echinococcus multilocularis	carbonic anhydrase II	0.0214	0.1435	0.1435
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0082	0.0082
Echinococcus granulosus	tar DNA binding protein	0.0543	0.3898	0.3898
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0082	0.0082
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0058	0.0267	0.0267
Trypanosoma cruzi	PAB1-binding protein , putative	0.0162	0.1043	0.7269
Echinococcus multilocularis	smad	0.0034	0.0086	0.0086
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0584	0.0584
Schistosoma mansoni	Smad4	0.0034	0.0086	0.0086
Brugia malayi	G-protein alpha subunit	0.0058	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0584	0.0584
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0058	0.0267	0.0267
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0214	0.1435	0.1435
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0058	0.0267	0.0267
Loa Loa (eye worm)	G protein alpha subunit 3	0.0058	0.0267	0.0267
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0058	0.0267	0.0267
Schistosoma mansoni	tar DNA-binding protein	0.0543	0.3898	0.3898
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0058	0.0267	1
Echinococcus granulosus	carbonic anhydrase II	0.0214	0.1435	0.1435
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0058	0.0267	0.0267
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0101	0.0584	0.0584
Onchocerca volvulus		0.0058	0.0267	0.1003
Onchocerca volvulus		0.0058	0.0267	0.1003
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0073	0.0375	0.0375
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0058	0.0267	0.0267
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0086	0.0086
Loa Loa (eye worm)	pax transcription factor protein 2	0.0259	0.1766	0.1766
Brugia malayi	MH1 domain containing protein	0.0034	0.0086	0.0086
Schistosoma mansoni	tar DNA-binding protein	0.0543	0.3898	0.3898
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0023	0	0.5
Schistosoma mansoni	hypothetical protein	0.0034	0.0082	0.0082
Echinococcus granulosus	Smad4	0.0034	0.0086	0.0086
Echinococcus multilocularis	tar DNA binding protein	0.0543	0.3898	0.3898
Brugia malayi	hypothetical protein	0.0105	0.0614	0.0614
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0058	0.0267	0.0267
Plasmodium falciparum	ataxin-2 like protein, putative	0.0162	0.1043	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0584	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0082	0.0082
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0058	0.0267	0.0267
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0584	0.0584
Schistosoma mansoni	hypothetical protein	0.0101	0.0584	0.0584
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0058	0.0267	1
Brugia malayi	Smad1	0.0034	0.0086	0.0086
Brugia malayi	MH2 domain containing protein	0.0034	0.0086	0.0086
Loa Loa (eye worm)	carbonic anhydrase 3	0.0214	0.1435	0.1435
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1358	1	1
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0584	0.0584
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0058	0.0267	0.0267
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0058	0.0267	0.0267
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0058	0.0267	0.0267
Leishmania major	hypothetical protein, conserved	0.0162	0.1043	0.7269
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.0086	0.0086
Trypanosoma cruzi	PAB1-binding protein , putative	0.0162	0.1043	0.7269
Brugia malayi	RNA recognition motif domain containing protein	0.0543	0.3898	0.3898
Giardia lamblia	DUB-1	0.0023	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0267	0.0267
Loa Loa (eye worm)	Smad1	0.0034	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0625	0.0625
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0086	0.0086
Plasmodium falciparum	carbonic anhydrase	0.0101	0.0584	0.5601
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0379	0.2666	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0214	0.1435	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.1358	1	1
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0058	0.0267	0.0267
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1358	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.0625	0.0625
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0082	0.0082
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0058	0.0267	0.0267
Giardia lamblia	Hypothetical protein	0.0023	0	0.5
Echinococcus granulosus	GPCR family 2	0.0034	0.0082	0.0082
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.1358	1	1
Brugia malayi	MH2 domain containing protein	0.05	0.3573	0.3573
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0058	0.0267	0.0267
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0034	0.0086	0.0086
Trypanosoma brucei	carbonic anhydrase-like protein	0.0214	0.1435	1
Brugia malayi	MH1 domain containing protein	0.0034	0.0086	0.0086
Plasmodium vivax	ataxin-2 like protein, putative	0.0162	0.1043	1
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0058	0.0267	0.0267
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0086	0.0086
Echinococcus granulosus	mothers against decapentaplegic 5	0.0034	0.0086	0.0086
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0584	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0374	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0267	0.0267
Brugia malayi	TAR-binding protein	0.0543	0.3898	0.3898
Schistosoma mansoni	hypothetical protein	0.0034	0.0082	0.0082
Toxoplasma gondii	LsmAD domain-containing protein	0.0162	0.1043	1
Echinococcus granulosus	expressed protein	0.0058	0.0267	0.0267
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0058	0.0267	0.0267
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0584	0.0584
Echinococcus granulosus	smad	0.0034	0.0086	0.0086
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0214	0.1435	0.1435
Loa Loa (eye worm)	RNA binding protein	0.0543	0.3898	0.3898
Schistosoma mansoni	tar DNA-binding protein	0.0543	0.3898	0.3898
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0058	0.0267	0.0267
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.1358	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.05	0.3573	0.3573
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0082	0.0082
Brugia malayi	N-terminal motif family protein	0.0379	0.2666	0.2666
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0058	0.0267	0.0267
Brugia malayi	hypothetical protein	0.0162	0.1043	0.1043
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0058	0.0267	0.0267
Schistosoma mansoni	carbonic anhydrase	0.0101	0.0584	0.0584
Plasmodium falciparum	ataxin-2 like protein, putative	0.0162	0.1043	1
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0058	0.0267	1
Leishmania major	carbonic anhydrase-like protein	0.0214	0.1435	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0162	0.1043	0.7269
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0543	0.3898	0.3898
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0058	0.0267	0.0267
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0082	0.0082
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0058	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0267	0.0267
Entamoeba histolytica	G protein alpha subunit, putative	0.0058	0.0267	1
Schistosoma mansoni	hypothetical protein	0.0073	0.0374	0.0374
Schistosoma mansoni	tar DNA-binding protein	0.0543	0.3898	0.3898
Loa Loa (eye worm)	transcription factor SMAD2	0.05	0.3573	0.3573
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0058	0.0267	0.0267
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0058	0.0267	1
Schistosoma mansoni	hypothetical protein	0.0073	0.0375	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0267	0.0267
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0584	0.0584
Toxoplasma gondii	hypothetical protein	0.0101	0.0584	0.5601
Brugia malayi	MH2 domain containing protein	0.0034	0.0086	0.0086
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.1358	1	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0584	0.0584
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0082	0.0082
Schistosoma mansoni	tar DNA-binding protein	0.0543	0.3898	0.3898
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0034	0.0086	0.0086

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 10 nM	Inhibitory activity against human recombinant carbonic anhydrase II	ChEMBL.	10411484
Ki (binding)	= 10 nM	Inhibitory activity against human recombinant carbonic anhydrase II	ChEMBL.	10411484
Ki (binding)	= 55 nM	Inhibitory activity against bovine lung microsomes carbonic anhydrase isozyme IV (bCA IV).	ChEMBL.	10411484
Ki (binding)	= 55 nM	Inhibitory activity against bovine lung microsomes carbonic anhydrase isozyme IV (bCA IV).	ChEMBL.	10411484
Ki (binding)	= 450 nM	Inhibitory activity against human cloned carbonic anhydrase isozyme I (hCA I, cytosolic form).	ChEMBL.	10411484
Ki (binding)	= 450 nM	Inhibitory activity against human cloned carbonic anhydrase isozyme I (hCA I, cytosolic form).	ChEMBL.	10411484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL89634
PubChem: 10838049

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 145777