Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0109 | 0.0998 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0109 | 0.0998 | 0.1529 |
Brugia malayi | Carboxylesterase family protein | 0.0643 | 0.6527 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0998 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0998 | 0.1529 |
Schistosoma mansoni | acetylcholinesterase | 0.0109 | 0.0998 | 0.1529 |
Echinococcus granulosus | neuroligin | 0.0109 | 0.0998 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0998 | 0.1529 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0109 | 0.0998 | 0.1529 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0109 | 0.0998 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0109 | 0.0998 | 0.1529 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0109 | 0.0998 | 0.1529 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0109 | 0.0998 | 0.1529 |
Onchocerca volvulus | 0.0109 | 0.0998 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0109 | 0.0998 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0998 | 0.1529 |
Onchocerca volvulus | 0.0109 | 0.0998 | 1 | |
Onchocerca volvulus | 0.0109 | 0.0998 | 1 | |
Brugia malayi | hypothetical protein | 0.0109 | 0.0998 | 0.1529 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0109 | 0.0998 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0109 | 0.0998 | 0.0998 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0109 | 0.0998 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0109 | 0.0998 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0998 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.6527 | 1 |
Onchocerca volvulus | 0.0109 | 0.0998 | 1 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0109 | 0.0998 | 0.0998 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0109 | 0.0998 | 0.0998 |
Brugia malayi | Carboxylesterase family protein | 0.0643 | 0.6527 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0998 | 0.1529 |
Schistosoma mansoni | gliotactin | 0.0109 | 0.0998 | 0.1529 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0109 | 0.0998 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0998 | 0.1529 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0643 | 0.6527 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0109 | 0.0998 | 0.1529 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0109 | 0.0998 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0643 | 0.6527 | 0.6527 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0109 | 0.0998 | 0.0998 |
Echinococcus multilocularis | acetylcholinesterase | 0.0643 | 0.6527 | 0.6527 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0109 | 0.0998 | 0.1529 |
Brugia malayi | Carboxylesterase family protein | 0.0109 | 0.0998 | 0.1529 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0109 | 0.0998 | 0.1529 |
Onchocerca volvulus | 0.0109 | 0.0998 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0643 | 0.6527 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0109 | 0.0998 | 0.1529 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0109 | 0.0998 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0643 | 0.6527 | 0.6527 |
Loa Loa (eye worm) | carboxylesterase | 0.0643 | 0.6527 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0109 | 0.0998 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.6527 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0643 | 0.6527 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0643 | 0.6527 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0643 | 0.6527 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3078 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.