Detailed information for compound 1457897

Basic information

Technical information
  • TDR Targets ID: 1457897
  • Name: 2-[(3,4-difluorophenyl)sulfonylamino]-N-(2-mo rpholin-4-ylphenyl)benzamide
  • MW: 473.492 | Formula: C23H21F2N3O4S
  • H donors: 2 H acceptors: 3 LogP: 3.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1NS(=O)(=O)c1ccc(c(c1)F)F)Nc1ccccc1N1CCOCC1
  • InChi: 1S/C23H21F2N3O4S/c24-18-10-9-16(15-19(18)25)33(30,31)27-20-6-2-1-5-17(20)23(29)26-21-7-3-4-8-22(21)28-11-13-32-14-12-28/h1-10,15,27H,11-14H2,(H,26,29)
  • InChiKey: FEFPMQDHAPTSSP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3,4-difluorophenyl)sulfonylamino]-N-(2-morpholinophenyl)benzamide
  • ZINC03215178
  • MLS000568943
  • SMR000150043

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0757 0.081
Loa Loa (eye worm) hypothetical protein 0.0041 0.0757 0.081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0757 0.081
Brugia malayi Nuclear hormone receptor-like 1 0.0271 0.8842 0.9461
Schistosoma mansoni coup transcription factor 0.0041 0.0757 0.0757
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1262 0.1351
Brugia malayi ecdysteroid receptor 0.0041 0.0757 0.081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0757 0.081
Brugia malayi steroid hormone receptor 0.0041 0.0757 0.081
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0087
Brugia malayi nuclear receptor NHR-88 0.0041 0.0757 0.081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1262 0.1262
Echinococcus multilocularis geminin 0.0205 0.6506 0.6506
Brugia malayi nuclear hormone receptor 0.0041 0.0757 0.081
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0263 0.8566 0.9166
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0757 0.081
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0081 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1262 0.1262
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0757 0.5537
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0757 0.5537
Schistosoma mansoni hypothetical protein 0.0205 0.6506 0.6506
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0757 0.081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0757 0.081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0757 0.081
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0757 0.081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1262 0.1262
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.9346 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0757 0.081
Brugia malayi hypothetical protein 0.0022 0.0081 0.0087
Schistosoma mansoni thyroid hormone receptor 0.0304 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0252 0.8166 0.8737
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0757 0.081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1262 0.1262
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1262 0.1351
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.9346 0.9346
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0757 0.0757
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0757 0.081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0757 0.081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0757 0.081
Loa Loa (eye worm) hypothetical protein 0.0041 0.0757 0.081
Onchocerca volvulus 0.0041 0.0757 0.5537
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0081 0.0081
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0087
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0757 0.081
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1262 0.1262
Brugia malayi Nuclear hormone receptor-like 1 0.0252 0.8166 0.8737
Loa Loa (eye worm) hypothetical protein 0.0041 0.0757 0.081
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0757 0.081
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0757 0.0757
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0757 0.0757
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0087
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0757 0.5537
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1262 0.1351
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0757 0.0757
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0757 0.0757
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.0286 0.9346 1
Schistosoma mansoni thyroid hormone receptor 0.0304 1 1
Onchocerca volvulus 0.0058 0.1368 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0757 0.081
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0757 0.081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0757 0.081
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0757 0.081
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0757 0.081
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0757 0.081
Loa Loa (eye worm) hypothetical protein 0.025 0.8085 0.865
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0757 0.0757
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0757 0.081
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0757 0.0757
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0081 0.0087
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0757 0.081
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0757 0.081
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0757 0.081
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4384 0.469
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0757 0.0757
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1368 0.1464
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0757 0.0757
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0757 0.081
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1262 0.1351
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0757 0.0757
Brugia malayi hypothetical protein 0.0022 0.0081 0.0087
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0081 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0757 0.081
Brugia malayi MH2 domain containing protein 0.0144 0.4384 0.469
Brugia malayi nuclear receptor RXR 0.0022 0.0081 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0757 0.081
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0757 0.081
Schistosoma mansoni hypothetical protein 0.0263 0.8566 0.8566
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.0041 0.0757 0.081
Echinococcus granulosus geminin 0.0205 0.6506 0.6961
Loa Loa (eye worm) hypothetical protein 0.0041 0.0757 0.081
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0757 0.0757
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4384 0.469
Brugia malayi Nuclear hormone receptor-like 1 0.0252 0.8166 0.8737
Brugia malayi hypothetical protein 0.0286 0.9346 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.1368 0.1368
Schistosoma mansoni hypothetical protein 0.0058 0.1368 0.1368
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0757 0.0757
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0757 0.081
Loa Loa (eye worm) hypothetical protein 0.0041 0.0757 0.081
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0263 0.8566 0.8566
Loa Loa (eye worm) hypothetical protein 0.0041 0.0757 0.081
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0757 0.081
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0757 0.081
Schistosoma mansoni hypothetical protein 0.0205 0.6506 0.6506
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0757 0.0757
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0757 0.081
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0757 0.0757

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.5875 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 141.2538 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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