Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hexokinase | 0.018 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0312 | 0.0312 |
Echinococcus granulosus | hexokinase | 0.018 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1212 | 0.1212 |
Onchocerca volvulus | 0.0113 | 0.6003 | 0.6003 | |
Schistosoma mansoni | lamin | 0.0033 | 0.1212 | 0.1212 |
Treponema pallidum | hexokinase (hxk) | 0.018 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.018 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.1212 | 0.1212 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1212 | 0.1212 |
Echinococcus granulosus | hexokinase | 0.018 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1212 | 0.1212 |
Trypanosoma cruzi | hexokinase, putative | 0.018 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.1212 | 0.1212 |
Leishmania major | hexokinase, putative | 0.018 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.018 | 1 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.1212 | 0.1212 | |
Plasmodium vivax | hexokinase, putative | 0.018 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.018 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.018 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.018 | 1 | 0.5 |
Onchocerca volvulus | 0.018 | 1 | 1 | |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0209 | 0.0209 |
Brugia malayi | Hexokinase family protein | 0.0113 | 0.6003 | 0.6003 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.659 | 0.659 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1212 | 0.1212 |
Entamoeba histolytica | hexokinase 1 | 0.018 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1212 | 0.1212 |
Echinococcus multilocularis | hexokinase | 0.018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0174 | 0.0174 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1212 | 0.1212 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0209 | 0.0209 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1212 | 0.1212 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0174 | 0.0174 |
Plasmodium falciparum | hexokinase | 0.018 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0113 | 0.6003 | 0.6003 |
Loa Loa (eye worm) | hexokinase | 0.0056 | 0.2592 | 0.2592 |
Brugia malayi | hexokinase type II | 0.0057 | 0.2684 | 0.2684 |
Onchocerca volvulus | 0.018 | 1 | 1 | |
Echinococcus granulosus | hexokinase | 0.018 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1212 | 0.1212 |
Loa Loa (eye worm) | hexokinase | 0.018 | 1 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.0113 | 0.6003 | 0.6003 |
Brugia malayi | Hexokinase family protein | 0.018 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.018 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.018 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1177 | 0.1177 |
Brugia malayi | Hexokinase family protein | 0.0056 | 0.2592 | 0.2592 |
Onchocerca volvulus | 0.018 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0209 | 0.0209 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2684 | 0.2684 |
Echinococcus granulosus | hexokinase type 2 | 0.018 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.018 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1212 | 0.1212 |
Schistosoma mansoni | hexokinase | 0.018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1212 | 0.1212 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1212 | 0.1212 |
Trypanosoma cruzi | hexokinase, putative | 0.018 | 1 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.1212 | 0.1212 | |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2684 | 0.2684 |
Echinococcus multilocularis | hexokinase | 0.018 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.018 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.