Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.1364 | 0.1364 |
Brugia malayi | hypothetical protein | 0.0102 | 0.1364 | 0.1364 |
Echinococcus granulosus | neuroligin | 0.0102 | 0.1364 | 0.1364 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0603 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0102 | 0.1364 | 0.1364 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0603 | 1 | 1 |
Onchocerca volvulus | 0.0102 | 0.1364 | 0.5 | |
Schistosoma mansoni | acetylcholinesterase | 0.0102 | 0.1364 | 0.1364 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1364 | 0.1364 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.1364 | 0.1364 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0102 | 0.1364 | 0.1364 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1364 | 0.1364 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0102 | 0.1364 | 0.1364 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0102 | 0.1364 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0102 | 0.1364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1364 | 0.1364 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0102 | 0.1364 | 0.1364 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0603 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0102 | 0.1364 | 0.1364 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.1364 | 0.1364 |
Onchocerca volvulus | 0.0102 | 0.1364 | 0.5 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0102 | 0.1364 | 0.1364 |
Echinococcus granulosus | acetylcholinesterase | 0.0603 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.1364 | 0.1364 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1364 | 0.1364 |
Echinococcus multilocularis | neuroligin | 0.0102 | 0.1364 | 0.1364 |
Onchocerca volvulus | 0.0102 | 0.1364 | 0.5 | |
Onchocerca volvulus | 0.0102 | 0.1364 | 0.5 | |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0603 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0102 | 0.1364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0603 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0603 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0603 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.1364 | 0.1364 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0102 | 0.1364 | 1 |
Onchocerca volvulus | 0.0102 | 0.1364 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0603 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1364 | 0.1364 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0603 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0102 | 0.1364 | 0.1364 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.1364 | 0.1364 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0102 | 0.1364 | 0.1364 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0603 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0102 | 0.1364 | 0.1364 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0102 | 0.1364 | 0.1364 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0603 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0102 | 0.1364 | 0.1364 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0.1364 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0102 | 0.1364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1364 | 0.1364 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1364 | 0.1364 |
Loa Loa (eye worm) | carboxylesterase | 0.0102 | 0.1364 | 0.1364 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.