Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.4386 | 0.5743 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0195 | 0.3801 | 0.4978 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.3801 | 1 |
Brugia malayi | RNA binding protein | 0.0195 | 0.3801 | 0.4978 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.7636 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0195 | 0.3801 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.3801 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.3801 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0195 | 0.3801 | 0.4978 |
Loa Loa (eye worm) | TAR-binding protein | 0.0195 | 0.3801 | 0.4978 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0204 | 0.4386 | 0.5743 |
Brugia malayi | TAR-binding protein | 0.0195 | 0.3801 | 0.4978 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0195 | 0.3801 | 0.4978 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0204 | 0.4386 | 0.5743 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0204 | 0.4386 | 0.5743 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.3801 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.7636 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0195 | 0.3801 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.3801 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.