Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | Niemann-Pick disease, type C1 | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0004 | 0.0074 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0004 | 0.0246 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.0053 | 0.1032 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0121 | 0.0058 | 0.3747 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.0019 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.0085 | 0.544 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0023 | 0.1277 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0023 | 0.0448 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0026 | 0.1453 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0017 | 0.2949 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0004 | 0.0246 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 1.8691 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0017 | 0.0861 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.0087 | 0.5506 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.002 | 0.1284 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.002 | 0.1284 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.0087 | 0.5616 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.0085 | 0.1634 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0021 | 0.1129 |
Brugia malayi | TspO/MBR family protein | 0.0302 | 0.0156 | 1 |
Schistosoma mansoni | patched 1 | 0.0051 | 0.0021 | 0.1347 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.002 | 0.1284 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0017 | 0.1086 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0017 | 0.2949 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0004 | 0.0074 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0016 | 0.078 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0004 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0027 | 0.1534 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.0021 | 0.1363 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.0156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.0156 | 1 |
Echinococcus multilocularis | translocator protein | 0.0302 | 0.0156 | 0.3003 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.0156 | 1 |
Onchocerca volvulus | 0.0302 | 0.0156 | 0.5 | |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.0085 | 0.5447 |
Echinococcus multilocularis | protein dispatched 1 | 0.0058 | 0.0025 | 0.0479 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0017 | 0.2949 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0051 | 0.0021 | 0.1347 |
Brugia malayi | hypothetical protein | 0.0122 | 0.0059 | 0.3637 |
Echinococcus granulosus | expressed conserved protein | 0.0112 | 0.0053 | 0.3436 |
Onchocerca volvulus | 0.0302 | 0.0156 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0026 | 0.1453 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0017 | 0.1086 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0051 | 0.0021 | 0.0405 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0023 | 0.1492 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0004 | 0.0074 |
Echinococcus multilocularis | protein patched | 0.0051 | 0.0021 | 0.0405 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0023 | 0.1277 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.0057 | 0.3684 |
Onchocerca volvulus | 0.0302 | 0.0156 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.002 | 0.1284 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0051 | 0.0021 | 0.1129 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0017 | 0.2949 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.0057 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0017 | 0.0326 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0004 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0057 | 0.3524 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.0021 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.0087 | 0.5506 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0016 | 0.078 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0.0021 | 0.9886 |
Brugia malayi | CHE-14 protein | 0.0051 | 0.0021 | 0.1129 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0026 | 0.1453 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0004 | 0.0246 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0023 | 0.1492 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.0021 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0023 | 0.1492 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0026 | 0.1453 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.0302 | 0.0156 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.0057 | 0.1106 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0004 | 0.0246 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.0518 | 1 |
Onchocerca volvulus | 0.0302 | 0.0156 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0017 | 0.1086 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0119 | 0.0057 | 0.3524 |
Echinococcus granulosus | translocator protein | 0.0302 | 0.0156 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.0019 | 0.3298 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0016 | 0.1007 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.0087 | 0.1686 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 1.8691 | 1 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.0021 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.0021 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0023 | 0.1492 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0023 | 0.0448 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0051 | 0.0021 | 0.1347 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.0021 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0023 | 0.1492 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.0156 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0004 | 0.0246 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.0019 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 6.5104 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 7.3078 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.3183 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.