Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0334 | 1 | 1 |
Mycobacterium ulcerans | glutaminase | 0.031 | 0.9183 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0114 | 0.2599 | 0.2599 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2599 | 0.2599 |
Brugia malayi | glutaminase DH11.1 | 0.031 | 0.9183 | 0.9183 |
Loa Loa (eye worm) | glutaminase | 0.031 | 0.9183 | 0.9183 |
Schistosoma mansoni | tar DNA-binding protein | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0334 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0334 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0114 | 0.2599 | 0.2599 |
Schistosoma mansoni | tar DNA-binding protein | 0.0334 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0334 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.031 | 0.9183 | 0.9183 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.1396 | 0.1396 |
Trichomonas vaginalis | glutaminase, putative | 0.031 | 0.9183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1396 | 0.1396 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0334 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0078 | 0.1396 | 0.1396 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0114 | 0.2599 | 0.2599 |
Loa Loa (eye worm) | glutaminase 2 | 0.031 | 0.9183 | 0.9183 |
Loa Loa (eye worm) | TAR-binding protein | 0.0334 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0334 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0334 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0334 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0334 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.