TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.549 | Formula: C20H26O2S2
H donors: 0 H acceptors: 1 LogP: 5.39 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)CCC#Cc1ccc(cc1)C1SCC(CS1)C(C)(C)C
InChi: 1S/C20H26O2S2/c1-20(2,3)17-13-23-19(24-14-17)16-11-9-15(10-12-16)7-5-6-8-18(21)22-4/h9-12,17,19H,6,8,13-14H2,1-4H3
InChiKey: NAXZRUMPHRMRDF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0837	0.0837
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0018	0.0135	0.0135
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0015	0.0058	0.0058
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0018	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0425	1	1
Brugia malayi	Cation transporter family protein	0.0015	0.0058	0.0058
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0015	0.0058	0.0058
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0058	0.0058
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0018	0.0135	0.0135
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0149	0.3308	0.3308
Loa Loa (eye worm)	MH1 domain-containing protein	0.0018	0.0119	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Onchocerca volvulus		0.0015	0.0058	0.0068
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0018	0.0135	0.0135
Brugia malayi	MH2 domain containing protein	0.0018	0.0119	0.0119
Onchocerca volvulus		0.0018	0.0135	0.016
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Brugia malayi	hypothetical protein	0.0018	0.0135	0.0135
Echinococcus granulosus	Smad4	0.0018	0.0119	0.0119
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0058	0.0058
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0194	0.4398	0.4398
Entamoeba histolytica	G protein alpha subunit, putative	0.0018	0.0135	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0058	0.0058
Schistosoma mansoni	nAChR subunit	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0058	0.0058
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0361	0.846	0.846
Toxoplasma gondii	hypothetical protein	0.0018	0.0124	0.5
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0015	0.0058	0.0058
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0015	0.0058	0.0058
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0018	0.0135	0.0135
Echinococcus granulosus	tar DNA binding protein	0.0194	0.4398	0.4398
Brugia malayi	MH2 domain containing protein	0.0258	0.5952	0.5952
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0058	0.0058
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0015	0.0058	0.0058
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0058	0.0058
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0058	0.0058
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0018	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0124	0.0124
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0018	0.0124	0.0124
Schistosoma mansoni	nAChR subunit	0.0015	0.0058	0.0058
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0018	0.0135	0.0135
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0015	0.0058	0.0058
Schistosoma mansoni	nAChR subunit	0.0015	0.0058	0.0058
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.4398	0.4398
Echinococcus multilocularis	glycine receptor subunit beta	0.0015	0.0058	0.0058
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0425	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0124	0.0124
Echinococcus multilocularis	Smad4	0.0018	0.0119	0.0119
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0018	0.0135	0.0135
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0425	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0135	0.0135
Brugia malayi	G-protein alpha subunit	0.0018	0.0135	0.0135
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0058	0.0058
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0018	0.0124	0.0124
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0018	0.0135	0.0135
Echinococcus granulosus	segment polarity protein dishevelled	0.0018	0.0124	0.0124
Brugia malayi	MH1 domain containing protein	0.0018	0.0119	0.0119
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0018	0.0124	0.0146
Onchocerca volvulus		0.0018	0.0135	0.016
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0361	0.846	1
Echinococcus multilocularis	tar DNA binding protein	0.0194	0.4398	0.4398
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0018	0.0135	1
Loa Loa (eye worm)	TAR-binding protein	0.0194	0.4398	0.4398
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0018	0.0135	0.0135
Loa Loa (eye worm)	G protein alpha subunit 3	0.0018	0.0135	0.0135
Brugia malayi	hypothetical protein	0.0018	0.0124	0.0124
Schistosoma mansoni	hypothetical protein	0.0047	0.0837	0.0837
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0018	0.0119	0.0119
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0837	0.0837
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0015	0.0058	0.0058
Schistosoma mansoni	z-protein (S1r protein)	0.0018	0.0124	0.0124
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0015	0.0058	0.0058
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0018	0.0124	0.0124
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0837	0.0837
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0018	0.0135	0.0135
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Onchocerca volvulus		0.0015	0.0058	0.0068
Echinococcus multilocularis	segment polarity protein dishevelled	0.0018	0.0124	0.0124
Schistosoma mansoni	dishevelled	0.0018	0.0124	0.0124
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0425	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0058	0.0058
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0018	0.0135	0.0135
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0015	0.0058	0.0058
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0018	0.0135	1
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0018	0.0135	0.0135
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0018	0.0119	0.0119
Echinococcus granulosus	GPCR family 2	0.0047	0.0837	0.0837
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0058	0.0058
Schistosoma mansoni	smad	0.0018	0.0119	0.0119
Brugia malayi	N-terminal motif family protein	0.0361	0.846	0.846
Schistosoma mansoni	Smad4	0.0018	0.0119	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0018	0.0135	0.0135
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0018	0.0135	0.0135
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0058	0.0058
Echinococcus multilocularis	regulator of G protein signaling 7	0.0018	0.0124	0.0124
Schistosoma mansoni	dep domain containing protein	0.0018	0.0124	0.0124
Loa Loa (eye worm)	DIX domain-containing protein	0.0018	0.0124	0.0124
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.4398	0.4398
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0058	0.0058
Brugia malayi	RNA binding protein	0.0194	0.4398	0.4398
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0018	0.0135	1
Brugia malayi	hypothetical protein	0.0018	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0837	0.0837
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0018	0.0135	1
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0119	0.0119
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0015	0.0058	0.0058
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.4398	0.4398
Onchocerca volvulus		0.0018	0.0135	0.016
Schistosoma mansoni	nAChR subunit	0.0015	0.0058	0.0058
Schistosoma mansoni	nAChR subunit	0.0015	0.0058	0.0058
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0058	0.0058
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0058	0.0058
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.0837	0.0837
Onchocerca volvulus		0.0015	0.0058	0.0068
Brugia malayi	DIX domain containing protein	0.0018	0.0124	0.0124
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0018	0.0135	0.0135
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0018	0.0135	0.0135
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0018	0.0135	0.0135
Echinococcus granulosus	nAChR subunit	0.0015	0.0058	0.0058
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0018	0.0135	0.0135
Loa Loa (eye worm)	MH2 domain-containing protein	0.0258	0.5952	0.5952
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0018	0.0135	1
Trypanosoma cruzi	hypothetical protein	0.0013	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0058	0.0058
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0015	0.0058	0.0058
Onchocerca volvulus	Putative nachr subunit	0.0015	0.0058	0.0068
Brugia malayi	Smad1	0.0018	0.0119	0.0119
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0018	0.0119	0.0119
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0015	0.0058	0.0058
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0837	0.0837
Echinococcus granulosus	segment polarity protein dishevelled	0.0018	0.0124	0.0124
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0018	0.0135	0.0135
Echinococcus multilocularis	smad	0.0018	0.0119	0.0119
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0015	0.0058	0.0058
Schistosoma mansoni	dishevelled	0.0018	0.0124	0.0124
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0018	0.0135	0.0135
Onchocerca volvulus		0.0015	0.0058	0.0068
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.4398	0.4398
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0015	0.0058	0.0058
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0018	0.0135	0.0135
Schistosoma mansoni	hypothetical protein	0.0047	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0135	0.0135
Echinococcus granulosus	expressed protein	0.0018	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0102	0.2164	0.2164
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0149	0.3308	0.3308
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0018	0.0135	0.0135
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0837	0.0837
Echinococcus multilocularis	nAChR subunit	0.0015	0.0058	0.0058
Schistosoma mansoni	nAChR subunit	0.0015	0.0058	0.0058
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0018	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0018	0.0135	0.0135
Onchocerca volvulus		0.0015	0.0058	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Loa Loa (eye worm)	RNA binding protein	0.0194	0.4398	0.4398
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0018	0.0135	0.0135
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0018	0.0135	0.0135
Brugia malayi	MH2 domain containing protein	0.0018	0.0119	0.0119
Echinococcus granulosus	mothers against decapentaplegic 5	0.0018	0.0119	0.0119
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0015	0.0058	0.0058
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0058	0.0058
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0018	0.0135	1
Loa Loa (eye worm)	LGC-31 protein	0.0015	0.0058	0.0058
Brugia malayi	regulator of G-protein signaling egl-10	0.0018	0.0124	0.0124
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0425	1	1
Trypanosoma cruzi	hypothetical protein	0.0013	0	0.5
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0018	0.0135	0.0135
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0015	0.0058	0.0058
Brugia malayi	RNA recognition motif domain containing protein	0.0194	0.4398	0.4398
Brugia malayi	excitatory GABA receptor EXP-1A	0.0015	0.0058	0.0058
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0018	0.0135	0.0135
Echinococcus granulosus	glycine receptor subunit beta	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Schistosoma mansoni	regulator of G protein signaling	0.0018	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Echinococcus multilocularis	segment polarity protein dishevelled	0.0018	0.0124	0.0124
Schistosoma mansoni	hypothetical protein	0.0047	0.0837	0.0837
Echinococcus granulosus	regulator of G protein signaling 7	0.0018	0.0124	0.0124
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0124	0.0124
Onchocerca volvulus		0.0015	0.0058	0.0068
Loa Loa (eye worm)	MH2 domain-containing protein	0.0018	0.0119	0.0119
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0149	0.3308	0.3308
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0018	0.0124	0.0124
Brugia malayi	MH1 domain containing protein	0.0018	0.0119	0.0119
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0018	0.0124	0.0124
Echinococcus multilocularis	regulator of G protein signaling 7	0.0018	0.0124	0.0124
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0018	0.0135	0.0135
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0015	0.0058	0.0058
Loa Loa (eye worm)	transcription factor SMAD2	0.0258	0.5952	0.5952
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0058	0.0058
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0018	0.0124	0.0124
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0018	0.0135	0.0135
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0018	0.0135	1
Brugia malayi	TAR-binding protein	0.0194	0.4398	0.4398
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0018	0.0135	0.0135
Brugia malayi	latrophilin 2 splice variant baaae	0.0102	0.2164	0.2164
Brugia malayi	Cation transporter family protein	0.0015	0.0058	0.0058
Echinococcus granulosus	regulator of G protein signaling 7	0.0018	0.0124	0.0124
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0058	0.0058
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0119	0.0119
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0058	0.0058
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0425	1	1
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0018	0.0135	0.0135
Schistosoma mansoni	hypothetical protein	0.0047	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0015	0.0058	0.0058
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0018	0.0119	0.0119
Loa Loa (eye worm)	Smad1	0.0018	0.0119	0.0119
Brugia malayi	Cation transporter family protein	0.0015	0.0058	0.0058
Schistosoma mansoni	hypothetical protein	0.0102	0.2164	0.2164
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.4398	0.4398
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0018	0.0135	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0058	0.0058
Echinococcus multilocularis	expressed protein	0.0018	0.0135	0.0135
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0015	0.0058	0.0058
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0015	0.0058	0.0058
Echinococcus granulosus	smad	0.0018	0.0119	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0135	0.0135
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0015	0.0058	0.0058
Onchocerca volvulus		0.0018	0.0124	0.0146
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0425	1	1
Schistosoma mansoni	nAChR subunit	0.0015	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0149	0.3308	0.3308
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0018	0.0135	0.0135
Loa Loa (eye worm)	ACC-1 protein	0.0015	0.0058	0.0058
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0015	0.0058	0.0058
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0015	0.0058	0.0058
Trypanosoma cruzi	guanine nucleotide releasing protein, putative	0.0013	0	0.5
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0018	0.0135	0.0135
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0425	1	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0015	0.0058	0.0058
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.0837	0.0837
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0018	0.0135	0.0135
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0837	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0135	0.0135
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0119	0.0119

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 17 nM	Inhibition of [3H]-EBOB binding at GABA-gated chloride channel NCB site in bovine brain membranes	ChEMBL.	No reference
IC50 (binding)	= 17 nM	Inhibition of [3H]-EBOB binding at GABA-gated chloride channel NCB site in bovine brain membranes	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 145868