Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 1 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 1 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 1 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 1 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 1 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 1 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 1 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 1 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 1 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.