Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0862 | 0.792 | 0.792 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 0.2948 | 0.3464 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0066 | 0.0313 | 1 |
Onchocerca volvulus | 0.046 | 0.4076 | 0.5 | |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0066 | 0.0313 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0342 | 0.2948 | 0.3464 |
Schistosoma mansoni | tar DNA-binding protein | 0.0862 | 0.792 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0862 | 0.792 | 0.7883 |
Schistosoma mansoni | tar DNA-binding protein | 0.0862 | 0.792 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0862 | 0.792 | 0.7883 |
Schistosoma mansoni | tar DNA-binding protein | 0.0862 | 0.792 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.108 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0066 | 0.0313 | 0.5 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0174 | 0.0174 |
Brugia malayi | RNA binding protein | 0.0862 | 0.792 | 0.792 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0342 | 0.2948 | 0.3464 |
Echinococcus granulosus | tar DNA binding protein | 0.0862 | 0.792 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0342 | 0.2948 | 0.3464 |
Loa Loa (eye worm) | RNA binding protein | 0.0862 | 0.792 | 0.7883 |
Schistosoma mansoni | tar DNA-binding protein | 0.0862 | 0.792 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.2948 | 0.2823 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0066 | 0.0313 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0066 | 0.0313 | 0.0142 |
Schistosoma mansoni | tar DNA-binding protein | 0.0862 | 0.792 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0342 | 0.2948 | 0.2948 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0066 | 0.0313 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0342 | 0.2948 | 0.3464 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0066 | 0.0313 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0738 | 0.6736 | 0.6736 |
Brugia malayi | hypothetical protein | 0.046 | 0.4076 | 0.4076 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 0.6736 | 0.6678 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 0.2948 | 0.3464 |
Brugia malayi | isocitrate dehydrogenase | 0.0066 | 0.0313 | 0.0313 |
Schistosoma mansoni | hypothetical protein | 0.0738 | 0.6736 | 0.8444 |
Brugia malayi | MH2 domain containing protein | 0.0354 | 0.306 | 0.306 |
Echinococcus multilocularis | tar DNA binding protein | 0.0862 | 0.792 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.108 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0342 | 0.2948 | 0.2948 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.4076 | 0.3971 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0066 | 0.0313 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0342 | 0.2948 | 0.3464 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 0.2948 | 0.3464 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0066 | 0.0313 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0066 | 0.0313 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0066 | 0.0313 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0342 | 0.2948 | 0.3464 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0342 | 0.2948 | 0.2823 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 0.2948 | 0.3464 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0354 | 0.306 | 0.2937 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0862 | 0.792 | 0.792 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0354 | 0.306 | 0.2937 |
Brugia malayi | Isocitrate dehydrogenase | 0.0066 | 0.0313 | 0.0313 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 70 nM | Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand | ChEMBL. | 11206473 |
IC50 (binding) | = 70 nM | Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand | ChEMBL. | 11206473 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.