Detailed information for compound 1458806

Basic information

Technical information
  • TDR Targets ID: 1458806
  • Name: N-cyclopropyl-3-[(2-methyl-2,3-dihydroindol-1 -yl)sulfonyl]benzamide
  • MW: 356.439 | Formula: C19H20N2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.93 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1Cc2c(N1S(=O)(=O)c1cccc(c1)C(=O)NC1CC1)cccc2
  • InChi: 1S/C19H20N2O3S/c1-13-11-14-5-2-3-8-18(14)21(13)25(23,24)17-7-4-6-15(12-17)19(22)20-16-9-10-16/h2-8,12-13,16H,9-11H2,1H3,(H,20,22)
  • InChiKey: YBHUOUFUCFCXJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-cyclopropyl-3-(2-methylindolin-1-yl)sulfonyl-benzamide
  • N-cyclopropyl-3-[(2-methyl-1-indolinyl)sulfonyl]benzamide
  • MLS000057639
  • SMR000061038
  • Oprea1_368338
  • T0506-0983
  • Enamine_002015

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Brugia malayi hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni hypothetical protein 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni neuropeptide receptor 0.0035 0.2846 0.2846
Brugia malayi neuropeptide F receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0066 0.7495 0.8354
Schistosoma mansoni lamin 0.0033 0.2547 0.2547
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus granulosus g protein coupled receptor 0.0035 0.2846 0.3172
Schistosoma mansoni lamin 0.0033 0.2547 0.2547
Onchocerca volvulus 0.0035 0.2846 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.2846 0.2846
Echinococcus granulosus g-protein coupled receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Brugia malayi follicle stimulating hormone receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis lamin dm0 0.0033 0.2547 0.2839
Onchocerca volvulus 0.0035 0.2846 1
Schistosoma mansoni adenoreceptor 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.2846 0.2846
Onchocerca volvulus 0.0035 0.2846 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.2846 0.3172
Echinococcus granulosus sex peptide receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.2846 0.3172
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.2846 0.2846
Echinococcus multilocularis lamin 0.0033 0.2547 0.2839
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.2846 0.3172
Entamoeba histolytica hypothetical protein 0.0043 0.4138 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.2846 0.2846
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus granulosus neuropeptide s receptor 0.0035 0.2846 0.3172
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.2846 0.3172
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.2846 0.3172
Schistosoma mansoni amine GPCR 0.0035 0.2846 0.2846
Schistosoma mansoni histamine h1 receptor 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0032 0.246 0.2742
Schistosoma mansoni opsin-like receptor 0.0035 0.2846 0.2846
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.8236 1
Brugia malayi larval opioid receptor 0.0035 0.2846 0.3172
Schistosoma mansoni neuropeptide receptor 0.0035 0.2846 0.2846
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.2846 0.3172
Schistosoma mansoni amine GPCR 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.2846 0.3172
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.2846 0.3172
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.1028 0.1145
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Onchocerca volvulus 0.0035 0.2846 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.2846 0.3172
Schistosoma mansoni hypothetical protein 0.0043 0.4138 0.4138
Echinococcus granulosus tachykinin peptides receptor 99D 0.0035 0.2846 0.3172
Echinococcus granulosus lamin 0.0033 0.2547 0.2839
Schistosoma mansoni biogenic amine receptor 0.0035 0.2846 0.2846
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.2846 0.3172
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.2846 0.2846
Echinococcus granulosus lamin dm0 0.0033 0.2547 0.2839
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.2846 0.2846
Echinococcus multilocularis orexin receptor type 2 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Onchocerca volvulus 0.0035 0.2846 1
Brugia malayi hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.2846 0.3172
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.8236 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.2846 0.3172
Echinococcus multilocularis neuropeptide receptor 0.0035 0.2846 0.3172
Echinococcus granulosus g protein coupled receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Echinococcus multilocularis neuropeptide s receptor 0.0035 0.2846 0.3172
Onchocerca volvulus Neuropeptide F receptor homolog 0.0035 0.2846 1
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Brugia malayi ORL1-like opioid receptor 0.0035 0.2846 0.3172
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.1028 0.1028
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.2846 0.3172
Schistosoma mansoni amine GPCR 0.0035 0.2846 0.2846
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0337 0.0376
Onchocerca volvulus 0.0035 0.2846 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Entamoeba histolytica hypothetical protein 0.0043 0.4138 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus granulosus allatostatin A receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.2846 0.3172
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0094
Echinococcus granulosus fmrfamide receptor 0.0035 0.2846 0.3172
Schistosoma mansoni hypothetical protein 0.0035 0.2846 0.2846
Echinococcus granulosus serotonin receptor 0.0035 0.2846 0.3172
Brugia malayi Serotonin receptor 0.0035 0.2846 0.3172
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.1028 0.1145
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0084 0.0094
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.2846 0.3172
Echinococcus multilocularis neuropeptide receptor A26 0.0035 0.2846 0.3172
Schistosoma mansoni neuropeptide receptor 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus granulosus voltage gated potassium channel 0.0022 0.1028 0.1145
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0337 0.0376
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.2846 0.2846
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.2846 0.3172
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.2846 0.3172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.2846 0.2846
Schistosoma mansoni voltage-gated potassium channel 0.0084 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.2846 0.3172
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.2846 0.3172
Brugia malayi GnHR receptor homolog 0.0035 0.2846 0.3172
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0022 0.1028 0.1145
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus multilocularis musashi 0.0033 0.2547 0.2839
Schistosoma mansoni intermediate filament proteins 0.0033 0.2547 0.2547
Brugia malayi hypothetical protein 0.0035 0.2846 0.3172
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.2846 0.3172
Brugia malayi Serotonin receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.2846 0.2846
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Brugia malayi RE15519p 0.0035 0.2846 0.3172
Brugia malayi G protein-coupled receptor 0.0035 0.2846 0.3172
Onchocerca volvulus 0.0035 0.2846 1
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.2846 0.3172
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.1028 0.1145
Echinococcus granulosus neuropeptide receptor 0.0035 0.2846 0.3172
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.2846 0.2846
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.2846 0.3172
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.2846 0.3172
Echinococcus granulosus neuropeptide receptor A26 0.0035 0.2846 0.3172
Onchocerca volvulus 0.0035 0.2846 1
Schistosoma mansoni myosin xvIII 0.0035 0.2846 0.2846
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.2846 0.3172
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Brugia malayi G-protein coupled receptor 0.0035 0.2846 0.3172
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.2846 0.2846
Echinococcus multilocularis sex peptide receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis neuropeptide receptor 0.0035 0.2846 0.3172
Brugia malayi intermediate filament protein 0.0033 0.2547 0.2839
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.1028 0.1028
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.2846 0.2846
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0077 0.8972 1
Brugia malayi hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.2846 0.2846
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.2846 0.3172
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.2846 0.3172
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.2846 0.3172
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.2547 0.2839
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.2846 0.2846
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.2846 0.3172
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.2846 0.3172
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.2846 0.2846
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.4138 0.4612
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni hypothetical protein 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.2846 0.3172
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0035 0.2846 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.2846 0.2846
Echinococcus granulosus intermediate filament protein 0.0033 0.2547 0.2839
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.2846 0.2846
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.1028 0.1145
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.2846 0.3172
Brugia malayi sulfakinin receptor protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) intermediate filament protein 0.0033 0.2547 0.2839
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.2846 0.3172
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.2846 0.3172
Schistosoma mansoni biogenic amine receptor 0.0035 0.2846 0.2846
Echinococcus granulosus somatostatin receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.2846 0.3172
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.2846 0.3172
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.2846 0.3172
Onchocerca volvulus 0.0035 0.2846 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.2846 0.3172
Echinococcus multilocularis serotonin receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.2846 0.3172
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.2846 0.3172
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.2846 0.2846
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus multilocularis serotonin receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Onchocerca volvulus 0.0035 0.2846 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.2846 0.3172
Echinococcus multilocularis g protein coupled receptor 0.0035 0.2846 0.3172
Echinococcus granulosus g protein coupled receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni neuropeptide receptor 0.0035 0.2846 0.2846
Echinococcus multilocularis fmrfamide receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus multilocularis g protein coupled receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Onchocerca volvulus 0.0035 0.2846 1
Echinococcus multilocularis fmrfamide receptor 0.0035 0.2846 0.3172
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.2547 0.2839
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.2846 0.2846
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.2846 0.3172
Schistosoma mansoni amine GPCR 0.0035 0.2846 0.2846
Echinococcus granulosus orexin receptor type 2 0.0035 0.2846 0.3172
Schistosoma mansoni opsin-like receptor 0.0035 0.2846 0.2846
Brugia malayi G-protein coupled receptor 0.0035 0.2846 0.3172
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.2846 0.3172
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.4138 0.4138
Brugia malayi hypothetical protein 0.0043 0.4138 0.4612
Brugia malayi Dopamine receptor protein 2 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Brugia malayi putative neuropeptide receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.2846 0.3172
Brugia malayi hypothetical protein 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.2846 0.2846
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0035 0.2846 0.3172
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.2846 0.3172
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.2846 0.3172
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0077 0.8972 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.2846 0.2846
Brugia malayi Dopamine receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.2846 0.3172
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.2846 0.2846
Onchocerca volvulus 0.0035 0.2846 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.2846 0.2846
Echinococcus granulosus hypothetical protein 0.0035 0.2846 0.3172
Brugia malayi AKH receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0033 0.2547 0.2839
Brugia malayi hypothetical protein 0.0035 0.2846 0.3172
Schistosoma mansoni hypothetical protein 0.0035 0.2846 0.2846
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.2846 0.2846
Echinococcus granulosus neuropeptide receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis somatostatin receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0077 0.8972 1
Echinococcus multilocularis allatostatin A receptor 0.0035 0.2846 0.3172
Brugia malayi Melatonin receptor type 1A 0.0035 0.2846 0.3172
Onchocerca volvulus 0.0035 0.2846 1
Onchocerca volvulus 0.0035 0.2846 1
Schistosoma mansoni biogenic amine receptor 0.0035 0.2846 0.2846
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0084 0.0094
Onchocerca volvulus 0.0035 0.2846 1
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.4138 0.4612
Entamoeba histolytica hypothetical protein 0.0043 0.4138 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.2846 0.3172
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.2846 0.3172
Loa Loa (eye worm) hypothetical protein 0.0035 0.2846 0.3172
Entamoeba histolytica hypothetical protein 0.0043 0.4138 0.5
Brugia malayi hypothetical protein 0.0035 0.2846 0.3172
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.2846 0.3172
Schistosoma mansoni amine GPCR 0.0035 0.2846 0.2846
Brugia malayi hypothetical protein 0.0035 0.2846 0.3172
Brugia malayi Dopamine receptor protein 1 0.0035 0.2846 0.3172
Brugia malayi hypothetical protein 0.0035 0.2846 0.3172
Brugia malayi neuropeptide F receptor 0.0035 0.2846 0.3172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Echinococcus multilocularis g protein coupled receptor 0.0035 0.2846 0.3172
Brugia malayi hypothetical protein 0.0035 0.2846 0.3172
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.2846 0.3172
Onchocerca volvulus 0.0035 0.2846 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0077 0.8972 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.2846 0.3172
Onchocerca volvulus 0.0035 0.2846 1
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.2846 0.3172
Schistosoma mansoni opsin-like receptor 0.0035 0.2846 0.2846
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.2846 0.2846

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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