Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.5 | 0.5 | |
Brugia malayi | SH2 domain containing protein | 0.0018 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.5 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0018 | 0.5 | 0.5 | |
Brugia malayi | protein-tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.5 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0018 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0018 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0018 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0018 | 0.5 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0018 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0018 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0018 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0018 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0018 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0018 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Time (functional) | Analgesic activity in Mus musculus albino (mouse) assessed as latency time at 25 mg/kg, ip after 30 min in presence of 2 mg/kg, ip of mecamylamine by tail-flick test | ChEMBL. | No reference | |
TIME (functional) | = 5.16 s | Analgesic activity in Mus musculus albino (mouse) assessed as latency time at 25 mg/kg, ip after 30 min by tail-flick test | ChEMBL. | No reference |
Time (functional) | = 7.77 s | Analgesic activity in Mus musculus albino (mouse) assessed as latency time at 25 mg/kg, ip after 30 min by hot-plate test | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.