Detailed information for compound 1459273

Basic information

Technical information
  • TDR Targets ID: 1459273
  • Name: 3-(3,4-dimethoxyphenyl)-N-(1-phenylethyl)prop anamide
  • MW: 313.391 | Formula: C19H23NO3
  • H donors: 1 H acceptors: 1 LogP: 3.27 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CCC(=O)NC(c2ccccc2)C)ccc1OC
  • InChi: 1S/C19H23NO3/c1-14(16-7-5-4-6-8-16)20-19(21)12-10-15-9-11-17(22-2)18(13-15)23-3/h4-9,11,13-14H,10,12H2,1-3H3,(H,20,21)
  • InChiKey: ISQGFCBAQDFMFW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3,4-dimethoxyphenyl)-N-(1-phenylethyl)propionamide
  • T5210858

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.1281 0.0945
Trichomonas vaginalis helicase, putative 0.0008 0.0542 0.4149
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Brugia malayi Cyclic-nucleotide gated cation channel 0.0013 0.1281 0.0997
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.1281 0.1281
Echinococcus granulosus voltage gated hydrogen channel 1 0.0013 0.1281 0.1561
Schistosoma mansoni two-pore calcium channel 0.0013 0.1281 0.1281
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0013 0.1281 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0956 0.0754
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0013 0.1281 0.1561
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 0.4149
Loa Loa (eye worm) voltage-dependent calcium channel 0.0013 0.1281 0.0945
Echinococcus granulosus short transient receptor potential channel 6 0.0013 0.1281 0.1561
Schistosoma mansoni transient receptor potential channel 0.0013 0.1281 0.1281
Leishmania major hypothetical protein, unknown function 0.0013 0.1281 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.1281 0.1561
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.1281 0.1561
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0013 0.1281 0.1561
Echinococcus multilocularis two pore calcium channel protein 2 0.0013 0.1281 0.1561
Schistosoma mansoni cpg binding protein 0.0035 0.4403 0.4403
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0013 0.1281 0.1561
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Echinococcus multilocularis transfer RNA-Gly 0.0013 0.1281 0.1561
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.1281 0.1281
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Brugia malayi CXXC zinc finger family protein 0.0035 0.4403 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0013 0.1281 0.1561
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.1281 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.1281 0.1561
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0013 0.1281 0.0997
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0013 0.1281 0.0997
Echinococcus multilocularis cpg binding protein 0.0037 0.4688 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 0.4149
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.1281 0.1561
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0013 0.1281 0.1561
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0013 0.1281 0.1561
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Loa Loa (eye worm) voltage-gated potassium channel 0.0013 0.1281 0.0945
Echinococcus multilocularis sodium leak channel non selective protein 0.0013 0.1281 0.1561
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0013 0.1281 0.0997
Echinococcus granulosus shaker cognate 0.0013 0.1281 0.1561
Plasmodium falciparum zinc finger protein, putative 0.0004 0 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.1281 0.1561
Echinococcus multilocularis conserved hypothetical protein 0.0013 0.1281 0.1561
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0127 0.0127
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0013 0.1281 0.0997
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0013 0.1281 0.1281
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.1281 0.1281
Brugia malayi cation channel family protein 0.0013 0.1281 0.0997
Echinococcus multilocularis voltage dependent calcium channel 0.0013 0.1281 0.1561
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0651 0.0651
Echinococcus multilocularis shaker cognate 0.0013 0.1281 0.1561
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.1281 0.1561
Schistosoma mansoni voltage-gated ion channel 0.0013 0.1281 0.1281
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.1281 0.1281
Echinococcus multilocularis potassium large conductance calcium activated 0.0013 0.1281 0.1561
Echinococcus multilocularis short transient receptor potential channel 6 0.0013 0.1281 0.1561
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0013 0.1281 0.1561
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0013 0.1281 0.0997
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0013 0.1281 0.0997
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.1281 0.1281
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Echinococcus granulosus transient receptor potential gamma protein 0.0013 0.1281 0.1561
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 0.4149
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.1281 0.1561
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.1281 0.1281
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.1281 0.1281
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.1281 0.1561
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.1281 0.1561
Echinococcus granulosus voltage gated potassium channel 0.0013 0.1281 0.1561
Echinococcus granulosus hypothetical protein 0.0013 0.1281 0.1561
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0013 0.1281 0.1281
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0013 0.1281 0.5
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0013 0.1281 0.1561
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.1281 0.1561
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.1281 0.0945
Echinococcus granulosus two pore calcium channel protein 2 0.0013 0.1281 0.1561
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 0.4149
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0013 0.1281 0.1561
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0013 0.1281 0.1561
Echinococcus multilocularis transient receptor potential gamma protein 0.0013 0.1281 0.1561
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 0.4149
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.1281 0.1561
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.1281 0.1561
Schistosoma mansoni transient receptor potential channel 4 0.0013 0.1281 0.1281
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Schistosoma mansoni cpg binding protein 0.0037 0.4688 0.4688
Echinococcus granulosus voltage gated potassium channel 0.0013 0.1281 0.1561
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 0.4149
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0013 0.1281 0.1561
Schistosoma mansoni transient receptor potential channel 0.0013 0.1281 0.1281
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.1281 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0013 0.1281 0.1561
Onchocerca volvulus 0.0035 0.4403 1
Schistosoma mansoni hypothetical protein 0.0013 0.1281 0.1281
Leishmania major hypothetical protein, conserved 0.0013 0.1281 0.5
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0013 0.1281 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0013 0.1281 0.0997
Echinococcus granulosus potassium large conductance calcium activated 0.0013 0.1281 0.1561
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.1281 0.1561
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.1281 0.1561
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0956 0.0754
Loa Loa (eye worm) calcium channel 0.0013 0.1281 0.0945
Schistosoma mansoni cpg binding protein 0.0037 0.4688 0.4688
Echinococcus granulosus sodium channel protein 0.0013 0.1281 0.1561
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0013 0.1281 0.1561
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Brugia malayi olfactory channel protein osm-9 0.0013 0.1281 0.0997
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.1281 0.1561
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.1281 0.1561
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.1281 0.1561
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 0.4149
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.1281 0.1281
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 0.4149
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.1281 0.1281
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0013 0.1281 0.0997
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0013 0.1281 0.1561
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.1281 0.1561
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.1281 0.1561
Echinococcus multilocularis two pore calcium channel protein 1 0.0013 0.1281 0.1561
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0013 0.1281 0.0997
Echinococcus granulosus voltage dependent calcium channel 0.0013 0.1281 0.1561
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Echinococcus granulosus voltage dependent calcium channel 0.0013 0.1281 0.1561
Brugia malayi Transient-receptor-potential like protein 0.0013 0.1281 0.0997
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0013 0.1281 0.1561
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0013 0.1281 0.1561
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.1281 0.1561
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0013 0.1281 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.1281 0.1561
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.1281 0.0997
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0013 0.1281 0.1561
Schistosoma mansoni ryanodine receptor related 0.0013 0.1281 0.1281
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0013 0.1281 0.0997
Echinococcus granulosus cpg binding protein 0.0037 0.4688 1
Loa Loa (eye worm) ion channel NompC 0.0013 0.1281 0.0945
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0013 0.1281 0.1561
Echinococcus granulosus TRP transient receptor potential channel 0.0013 0.1281 0.1561
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.1281 0.1561
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0013 0.1281 0.0997
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 0.4149
Echinococcus multilocularis ryanodine receptor 44f 0.0013 0.1281 0.1561
Echinococcus granulosus calcium activated potassium channel 0.0013 0.1281 0.1561
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0013 0.1281 0.0945
Brugia malayi voltage-dependent calcium channel 0.0013 0.1281 0.0997
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 0.4149
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Loa Loa (eye worm) ryanodine receptor 0.0013 0.1281 0.0945
Echinococcus granulosus two pore calcium channel protein 1 0.0013 0.1281 0.1561
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0013 0.1281 0.1561
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0013 0.1281 0.1561
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.4403 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 0.4149
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0013 0.1281 0.1561
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Echinococcus granulosus short transient receptor potential channel 6 0.0013 0.1281 0.1561
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0013 0.1281 0.1281
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0013 0.1281 0.1561
Loa Loa (eye worm) voltage-gated calcium channel 0.0013 0.1281 0.0945
Brugia malayi ion channel NompC 0.0013 0.1281 0.0997
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.1281 0.1561
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0013 0.1281 0.0997
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0013 0.1281 0.1561
Echinococcus multilocularis voltage dependent calcium channel 0.0013 0.1281 0.1561
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0013 0.1281 0.0997
Brugia malayi hypothetical protein 0.0013 0.1281 0.0997
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.1281 0.1561
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.1281 0.1561
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0013 0.1281 0.1561
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0542 0.4149
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0013 0.1281 0.1281
Echinococcus multilocularis short transient receptor potential channel 6 0.0013 0.1281 0.1561
Schistosoma mansoni 60S ribosomal protein L21 0.0013 0.1281 0.1281
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0013 0.1281 0.5
Echinococcus granulosus ryanodine receptor 44f 0.0013 0.1281 0.1561
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.1281 0.1561
Entamoeba histolytica hypothetical protein 0.0004 0 0.5
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0013 0.1281 0.1281
Schistosoma mansoni voltage-gated cation channel 0.0013 0.1281 0.1281
Loa Loa (eye worm) voltage-gated potassium channel 0.0013 0.1281 0.0945
Echinococcus multilocularis calcium activated potassium channel 0.0013 0.1281 0.1561
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Echinococcus granulosus sodium leak channel non selective protein 0.0013 0.1281 0.1561
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 0.4149
Schistosoma mansoni calcium-activated potassium channel 0.0013 0.1281 0.1281
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.1281 0.1281
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 0.4149
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.1281 0.1561
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.8869 1
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Schistosoma mansoni transient receptor potential channel 0.0013 0.1281 0.1281
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0013 0.1281 0.1281
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.1281 0.1561
Echinococcus granulosus potassium voltage gated channel protein 0.0013 0.1281 0.1561
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0542 0.4149
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.1281 0.1561
Loa Loa (eye worm) hypothetical protein 0.0013 0.1281 0.0945
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0013 0.1281 0.1561
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0542 0.4149
Echinococcus multilocularis sodium channel protein 0.0013 0.1281 0.1561
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.1281 0.1561
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Schistosoma mansoni vesicular amine transporter 0.0013 0.1281 0.1281
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0013 0.1281 0.1561
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.1281 0.1281
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0013 0.1281 0.0997
Brugia malayi cation channel family protein 0.0013 0.1281 0.0997
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0013 0.1281 0.1561
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0542 0.4149
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0013 0.1281 0.1561
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.1281 0.1561
Echinococcus multilocularis potassium voltage gated channel protein 0.0013 0.1281 0.1561
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281
Schistosoma mansoni voltage-dependent calcium channel 0.0013 0.1281 0.1281
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.1281 0.1281

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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