Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0108 | 0.2836 | 0.2836 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.3695 | 0.3695 |
Schistosoma mansoni | glutaminase | 0.0295 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.1523 | 0.1523 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.3695 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0108 | 0.2836 | 0.2836 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3695 | 0.3695 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1523 | 0.1523 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.3695 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.3695 | 0.3695 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.3695 | 0.3695 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.1523 | 0.1523 |
Mycobacterium ulcerans | glutaminase | 0.0295 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3695 | 0.3695 |
Loa Loa (eye worm) | glutaminase 2 | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.3695 | 0.3695 |
Loa Loa (eye worm) | glutaminase | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0137 | 0.3946 | 0.3946 |
Brugia malayi | MH2 domain containing protein | 0.0137 | 0.3946 | 0.3946 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0137 | 0.3946 | 0.3946 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.3695 | 0.3695 |
Brugia malayi | RNA binding protein | 0.0131 | 0.3695 | 0.3695 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0108 | 0.2836 | 0.2836 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3695 | 0.3695 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3695 | 0.3695 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3695 | 0.3695 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2836 | 0.2836 |
Trichomonas vaginalis | glutaminase, putative | 0.0295 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.55 uM | Concentration required to reduce incorporation of [3H]-TdR in drug-treated cultures of intracellular Leishmania major to 50% of controls | ChEMBL. | 9258370 |
IC50 (functional) | = 0.55 uM | Concentration required to reduce incorporation of [3H]-TdR in drug-treated cultures of intracellular Leishmania major to 50% of controls | ChEMBL. | 9258370 |
IC50 (functional) | > 15 uM | Concentration required to reduce the growth of human Jurkat cells to 50% of control cultures | ChEMBL. | 9258370 |
IC50 (functional) | > 15 uM | Concentration required to reduce the growth of human Jurkat cells to 50% of control cultures | ChEMBL. | 9258370 |
Index | = 2 | Lipophilicity index (substitution method) | ChEMBL. | 9258370 |
Therapeutic index (ADMET) | > 27 | In vitro therapeutic index calculated as the IC50 ratio of Jurkat cells to that of Leishmania major. | ChEMBL. | 9258370 |
Therapeutic index (ADMET) | > 27 | In vitro therapeutic index calculated as the IC50 ratio of Jurkat cells to that of Leishmania major. | ChEMBL. | 9258370 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania major | ChEMBL23 | 9258370 | |
Homo sapiens | ChEMBL23 | 9258370 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.