Detailed information for compound 1459446

Basic information

Technical information
  • TDR Targets ID: 1459446
  • Name: N-(4-pyridin-2-yl-1,3-thiazol-2-yl)furan-2-ca rboxamide
  • MW: 271.294 | Formula: C13H9N3O2S
  • H donors: 1 H acceptors: 3 LogP: 2.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccco1)Nc1scc(n1)c1ccccn1
  • InChi: 1S/C13H9N3O2S/c17-12(11-5-3-7-18-11)16-13-15-10(8-19-13)9-4-1-2-6-14-9/h1-8H,(H,15,16,17)
  • InChiKey: VATWTDBEFFIYEH-UHFFFAOYSA-N  

Network

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Synonyms

  • N-[4-(2-pyridyl)thiazol-2-yl]furan-2-carboxamide
  • N-[4-(2-pyridyl)-2-thiazolyl]-2-furancarboxamide
  • N-[4-(2-pyridyl)thiazol-2-yl]-2-furamide
  • T5277775
  • MLS000516225
  • SMR000342440
  • ZINC03369893
  • Oprea1_326864

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus ankyrin repeat protein 0.0679 0.6877 0.8108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0053 0.014
Loa Loa (eye worm) hypothetical protein 0.0052 0.0346 0.0644
Trypanosoma brucei unspecified product 0.0023 0.0053 0.014
Toxoplasma gondii protein c14orf29, putative 0.0021 0.0033 0.1013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0062
Onchocerca volvulus 0.0142 0.1284 0.2117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0053 0.014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3483 0.9693
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0064 0.0477 1
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.025 0.0688
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3483 0.9693
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0053 0.014
Echinococcus multilocularis geminin 0.0205 0.194 0.194
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0363 0.3592 1
Echinococcus granulosus Phospholipase carboxylesterase 0.0021 0.0033 0.0039
Schistosoma mansoni peptidase 0.0021 0.0033 0.0036
Mycobacterium ulcerans peptide amidase, GatA 0.0064 0.0477 0.1247
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0021 0.0033 0.0085
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0053 0.0059
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0363 0.3592 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3483 0.9693
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0021 0.0033 0.0085
Schistosoma mansoni bromodomain containing protein 0.0076 0.0606 0.0711
Trypanosoma cruzi serine peptidase, putative 0.0021 0.0033 0.0085
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.007 0.013
Loa Loa (eye worm) lipase 0.0142 0.1284 0.2389
Plasmodium falciparum lysophospholipase, putative 0.0021 0.0033 0.0068
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.025 0.0672
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0025 0.0026
Trypanosoma brucei monoglyceride lipase, putative 0.0363 0.3592 1
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0064 0.0477 0.0559
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3483 0.9693
Schistosoma mansoni hypothetical protein 0.0205 0.194 0.2284
Schistosoma mansoni amidase 0.0531 0.5337 0.6291
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0186 0.7333
Loa Loa (eye worm) amidase 0.0064 0.0477 0.0887
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0053 0.014
Loa Loa (eye worm) hypothetical protein 0.0535 0.5376 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0363 0.3592 1
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0021 0.0033 0.0085
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0009 0.0009
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0021 0.0033 0.1013
Mycobacterium tuberculosis Possible lysophospholipase 0.0363 0.3592 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0009 0.0017
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0021 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0085 0.0699 0.13
Schistosoma mansoni transcription factor btf3 0.0042 0.025 0.0291
Mycobacterium ulcerans hypothetical protein 0.0363 0.3592 1
Plasmodium falciparum esterase, putative 0.0021 0.0033 0.0068
Leishmania major monoglyceride lipase, putative 0.0363 0.3592 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0531 0.5337 0.6292
Trichomonas vaginalis lipase containing protein, putative 0.0142 0.1284 0.3515
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0009 0.0011
Onchocerca volvulus 0.0287 0.2795 0.5027
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0053 0.0055
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0033 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0033 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0053 0.014
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0263 0.0306
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0363 0.3592 1
Echinococcus granulosus transient receptor potential cation channel 0.0697 0.7058 0.8322
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0033 0.0068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0009 0.0009
Leishmania major DNA polymerase eta, putative 0.0038 0.0206 0.0566
Entamoeba histolytica hypothetical protein 0.0043 0.0263 0.0644
Trypanosoma cruzi serine peptidase, putative 0.0021 0.0033 0.0085
Mycobacterium ulcerans amidase 0.0064 0.0477 0.1247
Echinococcus multilocularis Protein lozenge 0.0067 0.0509 0.0509
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0561 0.0561
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8482 0.8482
Brugia malayi Lipase family protein 0.0142 0.1284 0.2389
Trypanosoma cruzi hypothetical protein, conserved 0.0142 0.1284 0.357
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1605 0.3619
Plasmodium vivax PST-A protein 0.0021 0.0033 0.0068
Echinococcus multilocularis ankyrin repeat protein 0.0679 0.6877 0.6877
Brugia malayi isocitrate dehydrogenase 0.0019 0.0009 0.0017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0262 0.0309
Leishmania major DNA polymerase eta, putative 0.0054 0.0373 0.1032
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0053 0.0123
Schistosoma mansoni fatty-acid amide hydrolase 0.0531 0.5337 0.6291
Mycobacterium ulcerans amidase 0.0064 0.0477 0.1247
Loa Loa (eye worm) runx1 0.0067 0.0509 0.0946
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0033 0.0068
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.025 0.0688
Mycobacterium ulcerans amidase 0.0064 0.0477 0.1247
Giardia lamblia DINP protein human, muc B family 0.0023 0.0053 0.0057
Echinococcus granulosus geminin 0.0205 0.194 0.2287
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0053 0.0055
Entamoeba histolytica hypothetical protein 0.0043 0.0263 0.0644
Plasmodium falciparum exported lipase 1 0.0021 0.0033 0.0068
Loa Loa (eye worm) hypothetical protein 0.0054 0.0373 0.0694
Plasmodium vivax PST-A protein 0.0021 0.0033 0.0068
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0531 0.5337 0.5337
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0009 0.0018
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0021 0.0033 0.0036
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0363 0.3592 1
Brugia malayi MGC79044 protein 0.0021 0.0033 0.0062
Loa Loa (eye worm) hypothetical protein 0.0148 0.135 0.2511
Echinococcus granulosus fatty acid amide hydrolase 1 0.0064 0.0477 0.0563
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0363 0.3592 1
Mycobacterium ulcerans amidase 0.0064 0.0477 0.1247
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0053 0.014
Echinococcus granulosus fatty acid amide hydrolase 1 0.0531 0.5337 0.6292
Toxoplasma gondii hypothetical protein 0.0021 0.0033 0.1013
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0053 0.0055
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0021 0.0033 0.0085
Mycobacterium ulcerans amidase 0.0064 0.0477 0.1247
Entamoeba histolytica hypothetical protein 0.0043 0.0263 0.0644
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0064 0.0477 0.1306
Trypanosoma cruzi amidase, putative 0.0064 0.0477 0.1322
Brugia malayi putative amidase 0.0064 0.0477 0.0887
Brugia malayi hypothetical protein 0.0535 0.5376 1
Trypanosoma cruzi amidase, putative 0.0064 0.0477 0.1322
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0053 0.014
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0053 0.0062
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0206 0.8174
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0053 0.014
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0009 0.0009
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0064 0.0477 0.0563
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0062
Echinococcus multilocularis zinc finger protein 0.0024 0.0056 0.0056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0053 0.0123
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0064 0.0477 0.1306
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0053 0.0055
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0064 0.0477 0.1306
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.04 0.04
Plasmodium falciparum lysophospholipase, putative 0.0363 0.3592 1
Plasmodium vivax alpha/beta hydrolase, putative 0.0021 0.0033 0.0068
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0172 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.04 0.0468
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1605 0.4415
Plasmodium falciparum lysophospholipase, putative 0.0363 0.3592 1
Brugia malayi Bromodomain containing protein 0.0046 0.0292 0.0543
Toxoplasma gondii hypothetical protein 0.0021 0.0033 0.1013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0561 0.0661
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0142 0.1284 0.1284
Loa Loa (eye worm) hypothetical protein 0.0535 0.5376 1
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0021 0.0033 0.0085
Plasmodium vivax PST-A protein 0.0021 0.0033 0.0068
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0053 0.014
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0679 0.6877 0.8107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3483 0.9693
Loa Loa (eye worm) hypothetical protein 0.0531 0.5337 0.9927
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0053 0.014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2426 0.4512
Brugia malayi PHD-finger family protein 0.003 0.0124 0.023
Echinococcus granulosus transcription factor btf3 0.0042 0.025 0.0295
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0033 0.0068
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0363 0.3592 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0186 0.0216
Leishmania major hypothetical protein, conserved 0.0021 0.0033 0.0085
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0009 0.0018
Brugia malayi hypothetical protein 0.0148 0.135 0.2511
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0062
Brugia malayi beta-NAC-like protein 0.0042 0.025 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0053 0.014
Toxoplasma gondii peptidase S15, putative 0.0021 0.0033 0.1013
Trypanosoma brucei lipase domain protein, putative 0.0142 0.1284 0.357
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0363 0.3592 1
Plasmodium falciparum epoxide hydrolase 2 0.0021 0.0033 0.0068
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0033 0.0068
Plasmodium falciparum esterase, putative 0.0021 0.0033 0.0068
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0053 0.0053
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.3483 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0021 0.0033 0.0085
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0064 0.0477 0.1306
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.025 0.0608
Plasmodium falciparum prodrug activation and resistance esterase 0.0021 0.0033 0.0068
Onchocerca volvulus Huntingtin homolog 0.0148 0.135 0.2243
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0009 0.0018
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8482 1
Trypanosoma brucei lipase domain protein, putative 0.0142 0.1284 0.357
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0021 0.0033 0.0036
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0021 0.0033 0.0085
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0094 0.0094
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0363 0.3592 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0025 0.0026
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0009 0.0007
Toxoplasma gondii phospholipase/carboxylesterase 0.0021 0.0033 0.1013
Leishmania major hypothetical protein, conserved 0.0142 0.1284 0.357
Loa Loa (eye worm) amidase 0.0064 0.0477 0.0887
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.025 0.0672
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0009 0.0018
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.025 0.0688
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.04 0.0468
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0373 0.0694
Schistosoma mansoni zinc finger protein 0.0024 0.0056 0.0063
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0064 0.0477 0.5
Plasmodium vivax unspecified product 0.0021 0.0033 0.0068
Plasmodium vivax unspecified product 0.0021 0.0033 0.0068
Onchocerca volvulus 0.0535 0.5376 1
Plasmodium falciparum exported lipase 2 0.0021 0.0033 0.0068
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0009 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.025 0.0608
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0053 0.014
Echinococcus multilocularis Phospholipase carboxylesterase 0.0021 0.0033 0.0033
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0032 0.006
Leishmania major hypothetical protein, conserved 0.0064 0.0477 0.1322
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0021 0.0033 0.1013
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3483 0.9693
Echinococcus granulosus abhydrolase domain containing protein 13 0.0021 0.0033 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0363 0.3592 1
Toxoplasma gondii hypothetical protein 0.0021 0.0033 0.1013
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.025 0.0608
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0186 0.0186
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0053 0.014
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0053 0.0059
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0062
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0206 0.0566
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0262 0.0262
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0053 0.0099
Brugia malayi hypothetical protein 0.0043 0.0263 0.0488
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0021 0.0033 0.1013
Leishmania major basic transcription factor 3a, putative 0.0042 0.025 0.0688
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0064 0.0477 0.1306
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0094 0.0107
Loa Loa (eye worm) hypothetical protein 0.0148 0.135 0.2511
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0053 0.014
Plasmodium falciparum esterase, putative 0.0363 0.3592 1
Plasmodium vivax PST-A protein 0.0363 0.3592 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0373 0.1032
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0094 0.0111
Echinococcus multilocularis transient receptor potential cation channel 0.0697 0.7066 0.7066
Echinococcus granulosus abhydrolase domain containing 3 0.0021 0.0033 0.0039
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0064 0.0477 0.1247
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3483 0.9693
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0021 0.0033 0.0068
Loa Loa (eye worm) ICD-1 protein 0.0042 0.025 0.0465
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8482 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.135 0.2243
Schistosoma mansoni hypothetical protein 0.0043 0.0263 0.0306
Plasmodium falciparum lysophospholipase, putative 0.0021 0.0033 0.0068
Trypanosoma brucei monoglyceride lipase, putative 0.0363 0.3592 1
Trypanosoma cruzi hypothetical protein, conserved 0.0142 0.1284 0.357
Plasmodium vivax lysophospholipase, putative 0.0021 0.0033 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0053 0.014
Trypanosoma cruzi monoglyceride lipase, putative 0.0363 0.3592 1
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0021 0.0033 0.0039
Echinococcus multilocularis abhydrolase domain containing 3 0.0021 0.0033 0.0033
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0531 0.5337 0.5337
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0009 0.0018
Plasmodium vivax PST-A protein 0.0021 0.0033 0.0068
Echinococcus multilocularis dna polymerase eta 0.0054 0.0373 0.0373
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0025 0.0029
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.3483 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3483 0.9693
Plasmodium falciparum BEM46-like protein, putative 0.0021 0.0033 0.0068
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.04 0.0471
Schistosoma mansoni lozenge 0.0067 0.0509 0.0597
Brugia malayi Amidase family protein 0.0064 0.0477 0.0887
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0263 0.031
Schistosoma mansoni fatty-acid amide hydrolase 0.0064 0.0477 0.0559
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0142 0.1284 0.1514
Toxoplasma gondii phospholipase 0.0021 0.0033 0.1013
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0053 0.0099
Brugia malayi Pre-SET motif family protein 0.0036 0.0186 0.0345
Brugia malayi MGC83647 protein 0.0021 0.0033 0.0062
Plasmodium vivax alpha/beta hydrolase, putative 0.0021 0.0033 0.0068
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0033 0.0068
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0064 0.0477 0.1306
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0021 0.0033 0.0085
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0033 0.0068
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0021 0.0033 0.0068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0049 0.0322 0.06
Brugia malayi Bromodomain containing protein 0.0091 0.0753 0.14
Echinococcus multilocularis transcription factor btf3 0.0042 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0363 0.3592 1
Brugia malayi Protein C20orf22 0.0021 0.0033 0.0062
Brugia malayi Pre-SET motif family protein 0.0251 0.2426 0.4512
Leishmania major hypothetical protein, conserved 0.0021 0.0033 0.0085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3483 0.9693
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0064 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0046 0.0293 0.0544
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0053 0.0055
Leishmania major DNA polymerase kappa, putative 0.0023 0.0053 0.014
Brugia malayi Amidase family protein 0.0064 0.0477 0.0887
Plasmodium vivax SET domain protein, putative 0.0036 0.0186 0.0493
Entamoeba histolytica hypothetical protein 0.0042 0.025 0.0608
Plasmodium vivax lysophospholipase, putative 0.0021 0.0033 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0053 0.014
Plasmodium falciparum alpha/beta hydrolase, putative 0.0021 0.0033 0.0068
Toxoplasma gondii hypothetical protein 0.0021 0.0033 0.1013
Plasmodium falciparum lysophospholipase, putative 0.0363 0.3592 1
Trichomonas vaginalis lipase containing protein, putative 0.0142 0.1284 0.3515
Echinococcus granulosus dna polymerase kappa 0.0023 0.0053 0.0062
Schistosoma mansoni hypothetical protein 0.0025 0.007 0.0079
Echinococcus granulosus zinc finger protein 0.0024 0.0056 0.0067
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0064 0.0477 0.1322
Schistosoma mansoni DNA polymerase eta 0.0054 0.0373 0.0437
Plasmodium vivax lysophospholipase, putative 0.0021 0.0033 0.0068
Plasmodium vivax PST-A protein 0.0021 0.0033 0.0068
Entamoeba histolytica hypothetical protein 0.0043 0.0263 0.0644
Mycobacterium ulcerans lysophospholipase 0.0363 0.3592 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0062
Brugia malayi amidase 0.0531 0.5337 0.9927
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1605 0.4453
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0373 0.1032
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0064 0.0477 0.0477
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0053 0.014
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2787 0.7737
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0064 0.0477 0.1306
Schistosoma mansoni hypothetical protein 0.0205 0.194 0.2284
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0053 0.0053
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0025 0.0025
Toxoplasma gondii NAC domain-containing protein 0.0042 0.025 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0053 0.014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0186 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.025 0.0608
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3483 0.9693
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0057 0.04 0.0744
Echinococcus granulosus dna polymerase eta 0.0054 0.0373 0.044
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0021 0.0033 0.0085

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 17.242 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
IC50 (functional) 7.125 uM PUBCHEM_BIOASSAY: Discovery of Small Molecule Probes for H1N1 Influenza NS1A. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504399] ChEMBL. No reference
MIC99 (functional) = 1.6 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv in GAST media with glycerol and alanine after 7 to 14 days by broth microdilution method ChEMBL. 24075144
MIC99 (functional) = 3.1 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv in Middlebrook 7H9 broth with glucose after 7 to 14 days by broth microdilution method ChEMBL. 24075144
MIC99 (functional) = 6.3 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv in Middlebrook 7H9 broth with butyrate after 7 to 14 days by broth microdilution method ChEMBL. 24075144
Potency (functional) 0.5174 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7308 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 15.8114 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Giardia lamblia growth inhibition. (Class of assay: confirmatory) [Related pubchem assays: 2451, 2472, 2464 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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