Detailed information for compound 1459448

Basic information

Technical information
  • TDR Targets ID: 1459448
  • Name: 7-(4-bromophenyl)-4-pyridin-3-yl-[1,2]oxazolo [3,4-d]pyridazine
  • MW: 353.173 | Formula: C16H9BrN4O
  • H donors: 0 H acceptors: 4 LogP: 2.57 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)c1nnc(c2c1noc2)c1cccnc1
  • InChi: 1S/C16H9BrN4O/c17-12-5-3-10(4-6-12)15-16-13(9-22-21-16)14(19-20-15)11-2-1-7-18-8-11/h1-9H
  • InChiKey: HLGBPJFTRPNCFX-UHFFFAOYSA-N  


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Synonyms

  • 7-(4-bromophenyl)-4-(3-pyridyl)isoxazolo[3,4-d]pyridazine
  • 7-(4-bromophenyl)-4-(3-pyridinyl)isoxazolo[3,4-d]pyridazine
  • MLS000547557
  • SMR000114637

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0001
Onchocerca volvulus 0.0014 0.0001 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0001 0.0001
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0001 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0014 0.0001 0.0001
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0001 0.0001
Echinococcus granulosus serotonin receptor 0.0014 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0001 0.0001
Brugia malayi putative amidase 0.0028 0.0259 0.0643
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0014 0.0001 0.5
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0019 0.0107 0.0107
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0156 0.267 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0028 0.0259 0.0259
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0001 0.0001
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0156 0.267 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni biogenic amine receptor 0.0014 0.0001 0.0001
Plasmodium vivax PST-A protein 0.0156 0.267 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0019 0.0107 0.0264
Loa Loa (eye worm) hypothetical protein 0.0048 0.065 0.1616
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0001 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0001 0.0001
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0028 0.0259 0.5
Echinococcus granulosus g protein coupled receptor 0.0014 0.0001 0.0001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.05 0.1533
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0266
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0019 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni amine GPCR 0.0014 0.0001 0.0001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0001 0.0001
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0001 0.0001
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0019 0.0107 0.0107
Onchocerca volvulus Neuropeptide F receptor homolog 0.0014 0.0001 0.5
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0156 0.267 1
Onchocerca volvulus 0.0014 0.0001 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0001 0.0002
Trypanosoma cruzi monoglyceride lipase, putative 0.0156 0.267 1
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0028 0.0259 0.5
Onchocerca volvulus 0.0014 0.0001 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) amidase 0.0028 0.0259 0.0645
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.0001 0.0001
Echinococcus granulosus orexin receptor type 2 0.0014 0.0001 0.0001
Echinococcus multilocularis serotonin receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0001 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0557 0.0557
Onchocerca volvulus 0.0014 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0001 0.0001
Onchocerca volvulus 0.0014 0.0001 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0107 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0054 0.0757 0.1881
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0001 0.0001
Echinococcus granulosus sex peptide receptor 0.0014 0.0001 0.0001
Onchocerca volvulus 0.0014 0.0001 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0026
Schistosoma mansoni myosin xvIII 0.0014 0.0001 0.0001
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0001 0.0001
Onchocerca volvulus 0.0014 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Onchocerca volvulus 0.0014 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0228 0.402 0.402
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0014 0.0001 0.0001
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0014 0.0001 0.0001
Echinococcus granulosus short transient receptor potential channel 6 0.0014 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Onchocerca volvulus 0.0014 0.0001 0.5
Schistosoma mansoni biogenic amine receptor 0.0014 0.0001 0.0001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.05 0.1533
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0001 0.0001
Plasmodium falciparum lysophospholipase, putative 0.0156 0.267 1
Echinococcus granulosus transient receptor potential cation channel 0.0547 0.999 1
Echinococcus granulosus g protein coupled receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0181 0.0451
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0107 0.0107
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0001 0.0002
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0107 0.0107
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0001 0.0002
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.001 0.001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Onchocerca volvulus 0.0014 0.0001 0.5
Echinococcus multilocularis somatostatin receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0001 0.0001
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0001 0.0001
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0054 0.0757 0.0757
Brugia malayi hypothetical protein 0.0043 0.0557 0.1384
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0181 0.0181
Schistosoma mansoni histamine h1 receptor 0.0014 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0001 0.0001
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0028 0.0259 0.0259
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0001 0.0002
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0534 0.9733 1
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis ankyrin repeat protein 0.0534 0.9733 0.9733
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni transient receptor potential channel 0.0014 0.001 0.0011
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0023 0.0181 0.0449
Onchocerca volvulus 0.0014 0.0001 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.0831 0.0854
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0001 0.0002
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0557 0.0572
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis short transient receptor potential channel 6 0.0014 0.001 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0001 0.0001
Echinococcus granulosus g protein coupled receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0001 0.0001
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0074 0.0076
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Onchocerca volvulus 0.0014 0.0001 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0001 0.0001
Echinococcus granulosus neuropeptide s receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus fatty acid amide hydrolase 1 0.0228 0.402 0.4024
Schistosoma mansoni opsin-like receptor 0.0014 0.0001 0.0001
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0074 0.0076
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0001 0.0001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0001 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0001
Loa Loa (eye worm) amidase 0.0028 0.0259 0.0645
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0001 0.0001
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0156 0.267 1
Echinococcus granulosus neuropeptide receptor 0.0014 0.0001 0.0001
Brugia malayi olfactory channel protein osm-9 0.0014 0.001 0.0024
Schistosoma mansoni opsin-like receptor 0.0014 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0014 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0181 0.0186
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0156 0.267 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0001 0.0001
Trypanosoma brucei monoglyceride lipase, putative 0.0156 0.267 1
Echinococcus granulosus fmrfamide receptor 0.0014 0.0001 0.0001
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0156 0.267 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0001 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0058 0.0831 0.0854
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0001 0.0001
Schistosoma mansoni fatty-acid amide hydrolase 0.0028 0.0259 0.0266
Onchocerca volvulus 0.0014 0.0001 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0001 0.0001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0001 0.0001
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0001 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0181 0.0182
Echinococcus granulosus allatostatin A receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Plasmodium falciparum lysophospholipase, putative 0.0156 0.267 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0107 0.0266
Schistosoma mansoni neuropeptide receptor 0.0014 0.0001 0.0001
Schistosoma mansoni opsin-like receptor 0.0014 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0001 0.0002
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0181 0.0182
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0054 0.0757 0.1882
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0156 0.267 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0001 0.0001
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0019 0.0107 0.0107
Echinococcus multilocularis sex peptide receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0107 0.0266
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Brugia malayi amidase 0.0228 0.402 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0156 0.267 1
Brugia malayi Amidase family protein 0.0028 0.0259 0.0643
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0001 0.0001
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0228 0.402 0.402
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Plasmodium falciparum esterase, putative 0.0156 0.267 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0001 0.0001
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0107 0.0107
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Onchocerca volvulus 0.0014 0.0001 0.5
Echinococcus granulosus fatty acid amide hydrolase 1 0.0028 0.0259 0.0259
Brugia malayi Amidase family protein 0.0028 0.0259 0.0643
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.267 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.402 1
Mycobacterium ulcerans lysophospholipase 0.0156 0.267 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0001 0.0001
Echinococcus granulosus hypothetical protein 0.0014 0.0001 0.0001
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0001 0.0001
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0001 0.0001
Echinococcus granulosus fatty acid amide hydrolase 1 0.0228 0.402 0.4024
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0028 0.0259 0.0259
Onchocerca volvulus 0.0014 0.0001 0.5
Schistosoma mansoni hypothetical protein 0.0043 0.0557 0.0572
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0001 0.0001
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0107 0.0107
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0028 0.0259 0.0266
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0001 0.0002
Schistosoma mansoni adenoreceptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0001 0.0002
Leishmania major monoglyceride lipase, putative 0.0156 0.267 1
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0001 0.0001
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0001 0.0001
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0001 0.0001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0107 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0001 0.0001
Trypanosoma brucei monoglyceride lipase, putative 0.0156 0.267 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Onchocerca volvulus 0.0014 0.0001 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0001 0.0001
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0107 0.0107
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0019 0.0107 0.0107
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0107 0.011
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0107 0.011
Echinococcus granulosus ankyrin repeat protein 0.0534 0.9733 0.9743
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0181 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0001 0.0001
Schistosoma mansoni fatty-acid amide hydrolase 0.0228 0.402 0.413
Schistosoma mansoni biogenic amine receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0001 0.0002
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Mycobacterium ulcerans hypothetical protein 0.0156 0.267 1
Echinococcus granulosus neuropeptide receptor 0.0014 0.0001 0.0001
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0107 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0001 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0054 0.0757 0.0757
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0001
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0001 0.0001
Mycobacterium tuberculosis Possible lysophospholipase 0.0156 0.267 1
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0028 0.0259 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.267 1
Echinococcus granulosus somatostatin receptor 0.0014 0.0001 0.0001
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0107 0.0107
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0001 0.0001
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0156 0.267 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0107 0.011
Echinococcus multilocularis serotonin receptor 0.0014 0.0001 0.0001
Plasmodium falciparum lysophospholipase, putative 0.0156 0.267 1
Onchocerca volvulus 0.0014 0.0001 0.5
Schistosoma mansoni amine GPCR 0.0014 0.0001 0.0001
Schistosoma mansoni amidase 0.0228 0.402 0.413
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0001 0.0001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.6212 um PUBCHEM_BIOASSAY: Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 629 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference
Potency (functional) 0.5174 uM PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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