TDR Targets

Basic information

Technical information

TDR Targets ID: 1459450
Name: ethyl 1-[2-(3-oxo-2-propan-2-yl-1,4-benzoxazi n-4-yl)acetyl]piperidine-4-carboxylate
MW: 388.457 | Formula: C21H28N2O5
H donors: 0 H acceptors: 3 LogP: 2.66 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1CCN(CC1)C(=O)CN1C(=O)C(Oc2c1cccc2)C(C)C
InChi: 1S/C21H28N2O5/c1-4-27-21(26)15-9-11-22(12-10-15)18(24)13-23-16-7-5-6-8-17(16)28-19(14(2)3)20(23)25/h5-8,14-15,19H,4,9-13H2,1-3H3
InChiKey: NNPXRKXKNPMIKR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 1-[2-(2-isopropyl-3-oxo-1,4-benzoxazin-4-yl)acetyl]piperidine-4-carboxylate
1-[2-(2-isopropyl-3-oxo-1,4-benzoxazin-4-yl)-1-oxoethyl]-4-piperidinecarboxylic acid ethyl ester
1-[2-(2-isopropyl-3-keto-1,4-benzoxazin-4-yl)acetyl]isonipecotic acid ethyl ester
ethyl 1-[2-(3-oxo-2-propan-2-yl-1,4-benzoxazin-4-yl)ethanoyl]piperidine-4-carboxylate
ASN 06912802

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	ATP-dependent Clp protease proteolytic subunit, related	Get druggable targets OG5_127187	All targets in OG5_127187
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	Probable ClpP-like protease	Get druggable targets OG5_127187	All targets in OG5_127187
Babesia bovis	ATP-dependent Clp protease proteolytic subunit 1, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium yoelii	ATP-dependent Clp protease, proteolytic subunit ClpP, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K06275 parvin, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	peptidase Clp S14 family	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Chlamydia trachomatis	hypothetical protein	ATP-dependent Clp protease proteolytic subunit	197 aa	171 aa	22.8 %
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	186 aa	40.3 %
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	ATP-dependent Clp protease proteolytic subunit	197 aa	172 aa	57.0 %
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	36.0 %
Schistosoma mansoni	neuropeptide receptor	ATP-dependent Clp protease proteolytic subunit	197 aa	174 aa	20.1 %
Onchocerca volvulus	Putative V-type proton ATPase subunit F	ATP-dependent Clp protease proteolytic subunit	197 aa	194 aa	54.1 %
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	180 aa	36.7 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Plasmodium yoelii	Clp protease	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.6 %
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.1 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	35.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0016	0.0052	0.0052
Brugia malayi	putative neuropeptide receptor NPR1	0.0016	0.0052	0.0036
Echinococcus multilocularis	voltage gated potassium channel	0.0016	0.0051	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Brugia malayi	G protein-coupled receptor F59B2.13	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Toxoplasma gondii	hypothetical protein	0.0044	0.0313	0.1873
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0044	0.0313	0.0313
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0044	0.0313	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0313	0.0298
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.0052	0.0036
Echinococcus granulosus	serotonin receptor	0.0016	0.0052	0.0036
Toxoplasma gondii	hypothetical protein	0.0044	0.0313	0.1873
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0313	0.0438
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0749	0.6813	1
Echinococcus multilocularis	g-protein coupled receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0016	0.0052	0.0036
Onchocerca volvulus		0.0058	0.0444	0.3003
Plasmodium falciparum	exported lipase 1	0.0044	0.0313	0.0162
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.0052	0.0052
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.0052	0.0052
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0012	0.0016	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0052	0.0052
Trypanosoma cruzi	amidase, putative	0.0132	0.1124	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0778	0.0864
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0044	0.0313	0.0298
Echinococcus granulosus	sex peptide receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.0052	0.0036
Leishmania major	hypothetical protein, conserved	0.0157	0.1357	0.1605
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	G protein coupled receptor 139	0.0016	0.0052	0.0036
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0688	0.6251	0.6251
Brugia malayi	follicle stimulating hormone receptor	0.0016	0.0052	0.0036
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.0052	0.0036
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0052	0.0052
Plasmodium vivax	PST-A protein	0.0044	0.0313	0.0162
Echinococcus granulosus	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	orexin receptor type 2	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0132	0.1124	0.111
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.0052	0.0036
Schistosoma mansoni	fatty-acid amide hydrolase	0.1094	1	1
Mycobacterium ulcerans	amidase	0.0132	0.1124	0.1247
Loa Loa (eye worm)	hypothetical protein	0.1094	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0052	0.0052
Brugia malayi	Protein C20orf22	0.0044	0.0313	0.0298
Echinococcus granulosus	sn1 specific diacylglycerol lipase beta	0.0157	0.1357	0.1343
Brugia malayi	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0062	0.0477	0.0463
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0016	0.0052	0.0036
Schistosoma mansoni	myosin xvIII	0.0016	0.0052	0.0052
Schistosoma mansoni	amine GPCR	0.0016	0.0052	0.0052
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1094	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0052	0.0036
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0012	0.0016	0.0016
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0132	0.1124	0.1388
Echinococcus granulosus	Phospholipase carboxylesterase	0.0044	0.0313	0.0298
Schistosoma mansoni	opsin-like receptor	0.0016	0.0052	0.0052
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0012	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0016	0.0052	0.0052
Schistosoma mansoni	opsin-like receptor	0.0016	0.0052	0.0052
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0313	0.0162
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0094	0.0778	0.0864
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0044	0.0313	0.0438
Echinococcus multilocularis	somatostatin receptor	0.0016	0.0052	0.0036
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.0044	0.0313	0.1873
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0044	0.0313	0.0162
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0044	0.0313	0.0298
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0313	0.0162
Echinococcus multilocularis	geminin	0.0205	0.1794	0.1781
Brugia malayi	hypothetical protein	0.0286	0.2541	0.2529
Echinococcus granulosus	somatostatin receptor	0.0016	0.0052	0.0036
Brugia malayi	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0132	0.1124	0.111
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Plasmodium falciparum	exported lipase 2	0.0044	0.0313	0.0162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0052	0.0052
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0016	0.0052	0.0036
Plasmodium vivax	lysophospholipase, putative	0.0044	0.0313	0.0162
Loa Loa (eye worm)	TYRA-2 protein	0.0016	0.0052	0.0036
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0044	0.0313	0.0438
Plasmodium falciparum	esterase, putative	0.0044	0.0313	0.0162
Brugia malayi	hypothetical protein	0.0016	0.0052	0.0036
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0012	0.0016	0.0016
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0016	0.0052	0.0036
Brugia malayi	G-protein coupled receptor	0.0016	0.0052	0.0036
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.2541	0.2529
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0052	0.0036
Trypanosoma brucei	lipase domain protein, putative	0.0157	0.1357	0.1605
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0016	0.0052	0.0036
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0778	0.0714
Echinococcus granulosus	G protein coupled receptor 139	0.0016	0.0052	0.0036
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.0052	0.0036
Toxoplasma gondii	hypothetical protein	0.0044	0.0313	0.1873
Brugia malayi	larval opioid receptor	0.0016	0.0052	0.0036
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0132	0.1124	0.111
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	ankyrin repeat protein	0.0688	0.6251	0.6245
Echinococcus granulosus	neuropeptide s receptor	0.0016	0.0052	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0313	0.0438
Loa Loa (eye worm)	amidase	0.0132	0.1124	0.111
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0044	0.0313	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0016	0.0052	0.0036
Plasmodium falciparum	esterase, putative	0.0044	0.0313	0.0162
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0044	0.0313	0.0162
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0044	0.0313	0.0438
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0094	0.0778	0.0763
Trypanosoma cruzi	hypothetical protein, conserved	0.0157	0.1357	0.1605
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0016	0.0052	0.0036
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0052	0.0052
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0016	0.0052	0.0036
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0016	0.0052	0.0036
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	abhydrolase domain containing 3	0.0044	0.0313	0.0298
Brugia malayi	Melatonin receptor type 1A	0.0016	0.0052	0.0036
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0044	0.0313	0.0298
Schistosoma mansoni	amine GPCR	0.0016	0.0052	0.0052
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.0052	0.0036
Brugia malayi	Dopamine receptor protein 2	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0778	0.0714
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.0052	0.0036
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0778	0.6226
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0016	0.0051	0.0036
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0044	0.0313	0.0438
Schistosoma mansoni	peptidase Clp (S14 family)	0.0094	0.0778	0.0778
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0778	0.0763
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0313	0.0438
Plasmodium vivax	alpha/beta hydrolase, putative	0.0044	0.0313	0.0162
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0044	0.0313	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Mycobacterium ulcerans	amidase	0.0132	0.1124	0.1247
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0749	0.6813	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0016	0.0051	0.0036
Echinococcus granulosus	ankyrin repeat protein	0.0688	0.6251	0.6245
Echinococcus multilocularis	neuropeptide s receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.0052	0.0036
Echinococcus granulosus	neuropeptide receptor	0.0016	0.0052	0.0036
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0016	0.0052	0.0036
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Schistosoma mansoni	hypothetical protein	0.0205	0.1794	0.1794
Trypanosoma cruzi	amidase, putative	0.0132	0.1124	0.1247
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0016	0.0052	0.0052
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Trichomonas vaginalis	lipase containing protein, putative	0.0157	0.1357	0.1973
Onchocerca volvulus		0.0157	0.1357	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0313	0.0298
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Echinococcus multilocularis	neuropeptide receptor A26	0.0016	0.0052	0.0036
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0052	0.0052
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Brugia malayi	RE15519p	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0313	0.0298
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0052	0.0036
Brugia malayi	G protein-coupled receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	serotonin receptor	0.0016	0.0052	0.0036
Plasmodium vivax	unspecified product	0.0044	0.0313	0.0162
Toxoplasma gondii	protein c14orf29, putative	0.0044	0.0313	0.1873
Echinococcus multilocularis	sn1 specific diacylglycerol lipase beta	0.0157	0.1357	0.1343
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Plasmodium vivax	PST-A protein	0.0044	0.0313	0.0162
Plasmodium falciparum	lysophospholipase, putative	0.0044	0.0313	0.0162
Schistosoma mansoni	voltage-gated potassium channel	0.0016	0.0051	0.0051
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0016	0.0052	0.0036
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0016	0.0052	0.0052
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0044	0.0313	0.0438
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0313	0.0438
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0749	0.6813	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0132	0.1124	0.111
Brugia malayi	hypothetical protein	0.0016	0.0052	0.0036
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0749	0.6813	1
Schistosoma mansoni	amine GPCR	0.0016	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0044	0.0313	0.0438
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0016	0.0052	0.0036
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0132	0.1124	1
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0361	0.0361
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0016	0.0052	0.0052
Loa Loa (eye worm)	amidase	0.0132	0.1124	0.111
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0778	0.5728
Plasmodium falciparum	lysophospholipase, putative	0.0044	0.0313	0.0162
Schistosoma mansoni	adenoreceptor	0.0016	0.0052	0.0052
Plasmodium vivax	PST-A protein	0.0044	0.0313	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Brugia malayi	MGC83647 protein	0.0044	0.0313	0.0298
Echinococcus multilocularis	sex peptide receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Schistosoma mansoni	amine GPCR	0.0016	0.0052	0.0052
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0313	0.0298
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0016	0.0052	0.0036
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0044	0.0313	0.0438
Plasmodium vivax	alpha/beta hydrolase, putative	0.0044	0.0313	0.0162
Echinococcus granulosus	voltage gated potassium channel	0.0016	0.0051	0.0036
Brugia malayi	Amidase family protein	0.0132	0.1124	0.111
Schistosoma mansoni	hypothetical protein	0.0205	0.1794	0.1794
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0052	0.0036
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0044	0.0313	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0051	0.0036
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0778	0.5728
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Plasmodium vivax	PST-A protein	0.0044	0.0313	0.0162
Brugia malayi	Dopamine receptor	0.0016	0.0052	0.0036
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0749	0.6813	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0749	0.6813	1
Plasmodium falciparum	lysophospholipase, putative	0.0749	0.6813	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0012	0.0016	0.0016
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0778	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0749	0.6813	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.0052	0.0036
Toxoplasma gondii	hypothetical protein	0.0044	0.0313	0.1873
Brugia malayi	hypothetical protein	0.0016	0.0052	0.0036
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0132	0.1124	1
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0313	0.0162
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0016	0.0052	0.0036
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.0052	0.0036
Brugia malayi	Serotonin receptor	0.0016	0.0052	0.0036
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.0052	0.0052
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0132	0.1124	0.1388
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0052	0.0036
Trypanosoma brucei	lipase domain protein, putative	0.0157	0.1357	0.1605
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0016	0.0052	0.0052
Echinococcus granulosus	dro:myosuppressin receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0325	0.031
Schistosoma mansoni	hypothetical protein	0.0016	0.0052	0.0052
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0052	0.0052
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0749	0.6813	1
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0132	0.1124	0.1247
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0052	0.0052
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0052	0.0052
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	lipase	0.0157	0.1357	0.1343
Leishmania major	monoglyceride lipase, putative	0.0749	0.6813	1
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0044	0.0313	0.0313
Brugia malayi	neuropeptide F receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.004	0.0274	0.0259
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0044	0.0313	0.0438
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0044	0.0313	0.0162
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1094	1	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0052	0.0052
Schistosoma mansoni	fatty-acid amide hydrolase	0.0132	0.1124	0.1124
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Trichomonas vaginalis	lipase containing protein, putative	0.0157	0.1357	0.1973
Schistosoma mansoni	peptidase	0.0044	0.0313	0.0313
Brugia malayi	Lipase family protein	0.0157	0.1357	0.1343
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0325	0.031
Plasmodium falciparum	prodrug activation and resistance esterase	0.0044	0.0313	0.0162
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0016	0.0052	0.0052
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0132	0.1124	0.1247
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0052	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0313	0.0438
Echinococcus granulosus	neuropeptide FF receptor 2	0.0016	0.0052	0.0036
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0052	0.0036
Brugia malayi	hypothetical protein	0.0016	0.0052	0.0036
Schistosoma mansoni	growth hormone secretagogue receptor	0.0016	0.0052	0.0052
Plasmodium falciparum	lysophospholipase, putative	0.0749	0.6813	1
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0132	0.1124	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0062	0.0477	0.0252
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0044	0.0313	0.1873
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Mycobacterium ulcerans	amidase	0.0132	0.1124	0.1247
Schistosoma mansoni	hypothetical protein	0.0058	0.0444	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0313	0.0298
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0044	0.0313	0.0162
Trypanosoma brucei	monoglyceride lipase, putative	0.0749	0.6813	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0062	0.0477	0.041
Brugia malayi	hypothetical protein	0.0016	0.0052	0.0036
Leishmania major	hypothetical protein, conserved	0.0044	0.0313	0.00000012837
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0313	0.0438
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0016	0.0052	0.0036
Schistosoma mansoni	opsin-like receptor	0.0016	0.0052	0.0052
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0016	0.0052	0.0036
Mycobacterium ulcerans	amidase	0.0132	0.1124	0.1247
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0132	0.1124	0.1247
Echinococcus granulosus	neuropeptide receptor	0.0016	0.0052	0.0036
Schistosoma mansoni	amidase	0.1094	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0016	0.0052	0.0036
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0132	0.1124	0.1247
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0016	0.0052	0.0036
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0778	1
Brugia malayi	AKH receptor	0.0016	0.0052	0.0036
Leishmania major	hypothetical protein, conserved	0.0132	0.1124	0.1247
Echinococcus multilocularis	transient receptor potential cation channel	0.0695	0.6319	0.6313
Brugia malayi	putative amidase	0.0132	0.1124	0.111
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0749	0.6813	1
Echinococcus multilocularis	allatostatin A receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0016	0.0052	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0749	0.6813	1
Echinococcus granulosus	allatostatin A receptor	0.0016	0.0052	0.0036
Toxoplasma gondii	peptidase S15, putative	0.0044	0.0313	0.1873
Mycobacterium ulcerans	amidase	0.0132	0.1124	0.1247
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1094	1	1
Echinococcus granulosus	transient receptor potential cation channel	0.0694	0.6309	0.6303
Echinococcus granulosus	orexin receptor type 2	0.0016	0.0052	0.0036
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0052	0.0036
Echinococcus granulosus	abhydrolase domain containing 3	0.0044	0.0313	0.0298
Echinococcus multilocularis	serotonin receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0016	0.0052	0.0036
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0016	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0286	0.2541	0.2529
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.0052	0.0052
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.0052	0.0036
Schistosoma mansoni	neuropeptide f receptor 76f	0.0016	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0052	0.0036
Brugia malayi	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Brugia malayi	Dopamine receptor protein 1	0.0016	0.0052	0.0036
Brugia malayi	hypothetical protein	0.0016	0.0052	0.0036
Plasmodium vivax	lysophospholipase, putative	0.0044	0.0313	0.0162
Brugia malayi	ORL1-like opioid receptor	0.0016	0.0052	0.0036
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0094	0.0778	0.0763
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0052	0.0052
Echinococcus granulosus	7TM GPCR rhodopsin	0.0016	0.0052	0.0036
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0444	0.0444
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0094	0.0778	0.0864
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0325	0.031
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0444	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0313	0.0438
Brugia malayi	putative neuropeptide receptor	0.0016	0.0052	0.0036
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0062	0.0477	0.0252
Echinococcus granulosus	neuropeptide receptor A26	0.0016	0.0052	0.0036
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.0052	0.0052
Plasmodium falciparum	epoxide hydrolase 2	0.0044	0.0313	0.0162
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0044	0.0313	0.1873
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0039	0.0267	0.037
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0361	0.0361
Brugia malayi	hypothetical protein	0.0016	0.0052	0.0036
Trypanosoma brucei	monoglyceride lipase, putative	0.0749	0.6813	1
Plasmodium falciparum	esterase, putative	0.0749	0.6813	1
Schistosoma mansoni	amine GPCR	0.0016	0.0052	0.0052
Brugia malayi	Probable ClpP-like protease	0.0094	0.0778	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Mycobacterium ulcerans	peptide amidase, GatA	0.0132	0.1124	0.1247
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0052	0.0036
Plasmodium falciparum	lysophospholipase, putative	0.0749	0.6813	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0016	0.0052	0.0036
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0016	0.0052	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0749	0.6813	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus granulosus	peptidase Clp S14 family	0.0062	0.0477	0.0463
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0052	0.0052
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0016	0.0052	0.0052
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0132	0.1124	0.1388
Brugia malayi	GnHR receptor homolog	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus granulosus	fmrfamide receptor	0.0016	0.0052	0.0036
Brugia malayi	G-protein coupled receptor	0.0016	0.0052	0.0036
Mycobacterium ulcerans	hypothetical protein	0.0749	0.6813	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0313	0.0438
Plasmodium falciparum	BEM46-like protein, putative	0.0044	0.0313	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus granulosus	7tm_1 domain containing protein	0.0016	0.0052	0.0036
Brugia malayi	sulfakinin receptor protein	0.0016	0.0052	0.0036
Plasmodium vivax	PST-A protein	0.0749	0.6813	1
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0132	0.1124	0.1247
Echinococcus multilocularis	dro:myosuppressin receptor	0.0016	0.0052	0.0036
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0039	0.0267	0.037
Schistosoma mansoni	hypothetical protein	0.0016	0.0052	0.0052
Schistosoma mansoni	voltage-gated potassium channel	0.0016	0.0051	0.0051
Loa Loa (eye worm)	melatonin receptor type 1A	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.0052	0.0052
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.2541	0.2529
Echinococcus granulosus	g-protein coupled receptor	0.0016	0.0052	0.0036
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0052	0.0036
Toxoplasma gondii	phospholipase/carboxylesterase	0.0044	0.0313	0.1873
Plasmodium vivax	PST-A protein	0.0044	0.0313	0.0162
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0132	0.1124	1
Brugia malayi	MGC79044 protein	0.0044	0.0313	0.0298
Toxoplasma gondii	phospholipase	0.0044	0.0313	0.1873
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0052	0.0052
Brugia malayi	Amidase family protein	0.0132	0.1124	0.111
Brugia malayi	neuropeptide F receptor	0.0016	0.0052	0.0036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0052	0.0036
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0016	0.0051	0.0036
Plasmodium vivax	lysophospholipase, putative	0.0044	0.0313	0.0162
Schistosoma mansoni	histamine h1 receptor	0.0016	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Mycobacterium tuberculosis	Possible lysophospholipase	0.0749	0.6813	1
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0132	0.1124	0.1247
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0132	0.1124	0.1247
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.0044	0.0313	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0052	0.0036
Trypanosoma cruzi	monoglyceride lipase, putative	0.0749	0.6813	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0157	0.1357	0.1605
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1094	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0052	0.0036
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.0052	0.0036
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0052	0.0052
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.0052	0.0036
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0044	0.0313	0.0162
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0325	0.031
Echinococcus granulosus	geminin	0.0205	0.1794	0.1781
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0132	0.1124	0.1388
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0016	0.0052	0.0052
Brugia malayi	Serotonin receptor	0.0016	0.0052	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0313	0.0438
Plasmodium vivax	unspecified product	0.0044	0.0313	0.0162
Mycobacterium ulcerans	lysophospholipase	0.0749	0.6813	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0052	0.0036

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.5481 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1393618

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1459450