Detailed information for compound 1459569

Basic information

Technical information
  • TDR Targets ID: 1459569
  • Name: 2-[(3-chlorophenyl)methyl]-8-methyl-N-(2-meth ylphenyl)-4,5-dihydrofuro[5,4-g]indazole-7-ca rboxamide
  • MW: 431.914 | Formula: C25H22ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 5.41 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)Cn1nc2c(c1)CCc1c2c(C)c(o1)C(=O)Nc1ccccc1C
  • InChi: 1S/C25H22ClN3O2/c1-15-6-3-4-9-20(15)27-25(30)24-16(2)22-21(31-24)11-10-18-14-29(28-23(18)22)13-17-7-5-8-19(26)12-17/h3-9,12,14H,10-11,13H2,1-2H3,(H,27,30)
  • InChiKey: KNTTYDSOBRXAAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3-chlorobenzyl)-8-methyl-N-(2-methylphenyl)-4,5-dihydrofuro[5,4-g]indazole-7-carboxamide
  • E233-1731
  • NCGC00121578-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens relaxin/insulin-like family peptide receptor 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi monoglyceride lipase, putative 0.0503 0.5989 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0458 0.0293
Trypanosoma cruzi amidase, putative 0.0101 0.1149 0.1505
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0164 0.016
Brugia malayi Lipase family protein 0.0142 0.1644 0.1644
Trichomonas vaginalis conserved hypothetical protein 0.0503 0.5989 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.066 0.0656
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.0458
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0458 0.0293
Loa Loa (eye worm) hypothetical protein 0.003 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.0458
Schistosoma mansoni hypothetical protein 0.0019 0.0164 0.016
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0101 0.1149 0.1505
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Brugia malayi MGC79044 protein 0.003 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.003 0.0291 0.0288
Leishmania major monoglyceride lipase, putative 0.0503 0.5989 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0503 0.5989 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.066 0.0647
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0053 0.0049
Echinococcus granulosus Phospholipase carboxylesterase 0.003 0.0291 0.0288
Plasmodium falciparum lysophospholipase, putative 0.0503 0.5989 1
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.0004 0.0004
Echinococcus granulosus ankyrin repeat protein 0.0158 0.1834 0.1831
Echinococcus multilocularis abhydrolase domain containing 3 0.003 0.0291 0.0288
Trypanosoma brucei lipase domain protein, putative 0.0142 0.1644 0.2373
Schistosoma mansoni smad1 5 8 and 0.001 0.0053 0.0049
Schistosoma mansoni hypothetical protein 0.0019 0.0164 0.016
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0101 0.1149 0.1505
Mycobacterium ulcerans amidase 0.0101 0.1149 0.1505
Loa Loa (eye worm) Smad1 0.001 0.0053 0.0053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0458 0.0293
Trypanosoma cruzi hypothetical protein, conserved 0.0142 0.1644 0.2373
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0101 0.1149 0.1505
Mycobacterium ulcerans amidase 0.0101 0.1149 0.1505
Echinococcus granulosus fatty acid amide hydrolase 1 0.0836 1 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0053 0.0049
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Brugia malayi MH2 domain containing protein 0.001 0.0053 0.0053
Echinococcus multilocularis Phospholipase carboxylesterase 0.003 0.0291 0.0288
Loa Loa (eye worm) hypothetical protein 0.006 0.0654 0.0654
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0458 0.0293
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.0004 0.0004
Schistosoma mansoni fatty-acid amide hydrolase 0.0836 1 1
Trichomonas vaginalis lipase containing protein, putative 0.0142 0.1644 0.2373
Brugia malayi putative amidase 0.0101 0.1149 0.1149
Onchocerca volvulus 0.0142 0.1644 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0503 0.5989 1
Trypanosoma cruzi amidase, putative 0.0101 0.1149 0.1505
Echinococcus multilocularis Smad4 0.001 0.0053 0.0049
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0458 0.0293
Plasmodium falciparum lysophospholipase, putative 0.0503 0.5989 1
Brugia malayi Amidase family protein 0.0101 0.1149 0.1149
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0158 0.1834 0.1831
Trichomonas vaginalis lipase containing protein, putative 0.0142 0.1644 0.2373
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0458 0.0293
Brugia malayi Amidase family protein 0.0101 0.1149 0.1149
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0164 0.016
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0101 0.1149 0.5
Echinococcus granulosus fatty acid amide hydrolase 1 0.0836 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.066 0.0656
Mycobacterium ulcerans peptide amidase, GatA 0.0101 0.1149 0.1505
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0458 0.0293
Loa Loa (eye worm) hypothetical protein 0.0019 0.0164 0.0164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0458 0.0454
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.003 0.0291 0.0288
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.066 1
Echinococcus granulosus abhydrolase domain containing protein 13 0.003 0.0291 0.0288
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0458 0.0293
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0053 0.0049
Giardia lamblia Cgi67 serine protease precursor-like protein 0.003 0.0291 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0458 0.0293
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.0004 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.066 0.066
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0458 0.0293
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0101 0.1149 0.1145
Brugia malayi Smad1 0.001 0.0053 0.0053
Mycobacterium ulcerans hypothetical protein 0.0503 0.5989 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0458 0.0293
Onchocerca volvulus 0.0043 0.0458 0.277
Loa Loa (eye worm) hypothetical protein 0.003 0.0291 0.0291
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0836 1 1
Onchocerca volvulus 0.0043 0.0458 0.277
Trypanosoma brucei lipase domain protein, putative 0.0142 0.1644 0.2373
Brugia malayi Calcium binding EGF domain containing protein 0.0006 0.0004 0.0004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0458 0.0458
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0503 0.5989 1
Loa Loa (eye worm) hypothetical protein 0.0836 1 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0101 0.1149 0.1145
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.0004 0.0004
Brugia malayi Protein C20orf22 0.003 0.0291 0.0291
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1671 0.1671
Echinococcus multilocularis ankyrin repeat protein 0.0158 0.1834 0.1831
Loa Loa (eye worm) lipase 0.0142 0.1644 0.1644
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.066 0.0656
Leishmania major hypothetical protein, conserved 0.003 0.0291 0.000000034959
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0836 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0458 0.0293
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0053 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0458 0.0454
Echinococcus granulosus tumor protein p63 0.0408 0.4849 0.4847
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0006 0.0004 0.0004
Plasmodium falciparum esterase, putative 0.0503 0.5989 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0101 0.1149 1
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0101 0.1149 0.1505
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0503 0.5989 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0053 0.0049
Echinococcus multilocularis tumor protein p63 0.0408 0.4849 0.4847
Loa Loa (eye worm) hypothetical protein 0.003 0.0291 0.0291
Mycobacterium ulcerans amidase 0.0101 0.1149 0.1505
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0164 0.016
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0019 0.0164 0.016
Mycobacterium tuberculosis Conserved protein 0.0043 0.0458 0.0293
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0006 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0291 0.0291
Brugia malayi beta-lactamase family protein 0.0043 0.0458 0.0458
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0503 0.5989 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.066 0.0656
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0458 0.0293
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.066 0.066
Mycobacterium ulcerans hypothetical protein 0.0043 0.0458 0.0293
Brugia malayi beta-lactamase 0.0043 0.0458 0.0458
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0458 0.0293
Onchocerca volvulus 0.0043 0.0458 0.277
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0006 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.0458
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0458 0.0293
Brugia malayi MH1 domain containing protein 0.001 0.0053 0.0053
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.066 0.0647
Leishmania major hypothetical protein, conserved 0.0043 0.0458 0.0293
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0053 0.0053
Leishmania major hypothetical protein, conserved 0.0142 0.1644 0.2373
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0101 0.1149 0.1248
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0164 0.0164
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0006 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.066 0.0647
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.328 0.5246
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0101 0.1149 0.1505
Brugia malayi MGC83647 protein 0.003 0.0291 0.0291
Trypanosoma brucei monoglyceride lipase, putative 0.0503 0.5989 1
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0142 0.1644 0.164
Mycobacterium tuberculosis Conserved protein 0.0043 0.0458 0.0293
Loa Loa (eye worm) amidase 0.0101 0.1149 0.1149
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0458 0.0293
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0458 0.0293
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.0004 0.0004
Echinococcus granulosus transient receptor potential cation channel 0.0158 0.1834 0.1831
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0503 0.5989 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0101 0.1149 0.1145
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0006 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0142 0.1644 0.164
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0101 0.1149 0.1505
Echinococcus granulosus Smad4 0.001 0.0053 0.0049
Echinococcus granulosus monoacylglycerol lipase abhd12 0.003 0.0291 0.0288
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0053 0.0049
Schistosoma mansoni Smad4 0.001 0.0053 0.0049
Schistosoma mansoni smad 0.001 0.0053 0.0049
Mycobacterium ulcerans lysophospholipase 0.0503 0.5989 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0458 0.0293
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0101 0.1149 0.1505
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0503 0.5989 1
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0101 0.1149 0.1505
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0654 0.065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.066 0.066
Onchocerca volvulus 0.006 0.0654 0.3964
Plasmodium falciparum lysophospholipase, putative 0.0503 0.5989 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.0458 0.0458
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0458 0.0454
Loa Loa (eye worm) hypothetical protein 0.006 0.066 0.066
Loa Loa (eye worm) hypothetical protein 0.0041 0.043 0.043
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0101 0.1149 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0291 0.0291
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0006 0.0004 0.0004
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0101 0.1149 0.1505
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0101 0.1149 0.1248
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0164 0.0164
Brugia malayi CUB domain containing protein 0.0006 0.0004 0.0004
Mycobacterium ulcerans lipase LipD 0.0043 0.0458 0.0293
Echinococcus multilocularis transient receptor potential cation channel 0.0158 0.1837 0.1833
Echinococcus multilocularis smad 0.001 0.0053 0.0049
Trypanosoma brucei monoglyceride lipase, putative 0.0503 0.5989 1
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0101 0.1149 0.1145
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.0458
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0458 0.0458
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0006 0.0004 0.0004
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.003 0.0291 0.0288
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0503 0.5989 1
Brugia malayi MH2 domain containing protein 0.001 0.0053 0.0053
Loa Loa (eye worm) amidase 0.0101 0.1149 0.1149
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0164 0.0164
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0458 0.0454
Brugia malayi enteropeptidase precursor 0.0006 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0142 0.1644 0.2373
Schistosoma mansoni peptidase 0.003 0.0291 0.0288
Trichomonas vaginalis esterase, putative 0.0043 0.0458 0.0293
Brugia malayi basement membrane proteoglycan precursor 0.0006 0.0004 0.0004
Echinococcus granulosus abhydrolase domain containing 3 0.003 0.0291 0.0288
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0101 0.1149 0.1505
Mycobacterium tuberculosis Possible lysophospholipase 0.0503 0.5989 1
Echinococcus granulosus smad 0.001 0.0053 0.0049
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0053 0.0049
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0101 0.1149 0.1145
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1671 0.1671
Mycobacterium ulcerans amidase 0.0101 0.1149 0.1505
Brugia malayi MH2 domain containing protein 0.0144 0.1671 0.1671
Echinococcus granulosus GPCR family 2 0.0019 0.0164 0.016
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.0458
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0503 0.5989 1
Brugia malayi MH1 domain containing protein 0.001 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0041 0.043 0.0426
Loa Loa (eye worm) hypothetical protein 0.0043 0.0458 0.0458
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0164 0.016
Mycobacterium ulcerans beta-lactamase 0.0043 0.0458 0.0293
Mycobacterium ulcerans amidase 0.0101 0.1149 0.1505
Plasmodium vivax PST-A protein 0.0503 0.5989 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0458 0.4525
Schistosoma mansoni amidase 0.0836 1 1
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0006 0.0004 0.0004
Brugia malayi beta-lactamase family protein 0.0043 0.0458 0.0458
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.066 0.0647
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0019 0.0164 0.016
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0503 0.5989 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.066 0.0647
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0458 0.0293
Echinococcus multilocularis GPCR, family 2 0.0019 0.0164 0.016
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0101 0.1149 0.1145

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.