Detailed information for compound 1459572

Basic information

Technical information
  • TDR Targets ID: 1459572
  • Name: 2-(3-methoxypropyl)-3H-isoindol-1-imine hydro bromide
  • MW: 285.18 | Formula: C12H17BrN2O
  • H donors: 0 H acceptors: 0 LogP: 2.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCN1Cc2c(C1=N)cccc2.Br
  • InChi: 1S/C12H16N2O.BrH/c1-15-8-4-7-14-9-10-5-2-3-6-11(10)12(14)13;/h2-3,5-6,13H,4,7-9H2,1H3;1H
  • InChiKey: IPAJWDGMOYHSSY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-methoxypropyl)isoindolin-1-imine hydrobromide
  • 2-(3-methoxypropyl)-1-isoindolinimine hydrobromide
  • [2-(3-methoxypropyl)isoindolin-1-ylidene]amine hydrobromide
  • 2-(3-methoxypropyl)-1-isoindoliniminium bromide
  • MLS000582736
  • SMR000201439
  • 2-(3-methoxypropyl)-3H-isoindol-2-ium-1-amine bromide
  • [2-(3-methoxypropyl)-3H-isoindol-2-ium-1-yl]amine bromide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0318 0.0521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0458 0.0426
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0677 0.6116 1
Mycobacterium ulcerans lysophospholipase 0.0677 0.6116 1
Plasmodium falciparum esterase, putative 0.0677 0.6116 1
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.004 0.0318 0.526
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.004 0.0318 0.0469
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0318 0.0521
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.004 0.0318 0.0286
Plasmodium falciparum lysophospholipase, putative 0.0677 0.6116 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0458 0.0426
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0286
Toxoplasma gondii phospholipase 0.004 0.0318 0.526
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0133 0.1167 0.1864
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0318 0.0521
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0385 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.6116 1
Trypanosoma cruzi hypothetical protein, conserved 0.0161 0.1417 0.2275
Loa Loa (eye worm) amidase 0.0133 0.1167 0.1138
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.004 0.0318 0.0469
Trypanosoma brucei monoglyceride lipase, putative 0.0677 0.6116 1
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0133 0.1167 0.1463
Brugia malayi putative amidase 0.0133 0.1167 0.1138
Leishmania major hypothetical protein, conserved 0.0161 0.1417 0.2275
Trypanosoma brucei monoglyceride lipase, putative 0.0677 0.6116 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0318 0.0521
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0458 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0318 0.0521
Trypanosoma brucei lipase domain protein, putative 0.0161 0.1417 0.2275
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1103 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0161 0.1417 0.2275
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0318 0.0521
Mycobacterium ulcerans amidase 0.0133 0.1167 0.1864
Echinococcus multilocularis ankyrin repeat protein 0.0178 0.1579 0.1551
Mycobacterium ulcerans amidase 0.0133 0.1167 0.1864
Loa Loa (eye worm) amidase 0.0133 0.1167 0.1138
Loa Loa (eye worm) hypothetical protein 0.1103 1 1
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0133 0.1167 0.1864
Onchocerca volvulus 0.0161 0.1417 0.5
Toxoplasma gondii hypothetical protein 0.004 0.0318 0.526
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0424 0.0182
Echinococcus granulosus fatty acid amide hydrolase 1 0.0133 0.1167 0.1138
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0318 0.0469
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0286
Schistosoma mansoni amidase 0.1103 1 1
Schistosoma mansoni fatty-acid amide hydrolase 0.1103 1 1
Mycobacterium ulcerans amidase 0.0133 0.1167 0.1864
Leishmania major monoglyceride lipase, putative 0.0677 0.6116 1
Trypanosoma cruzi serine peptidase, putative 0.004 0.0318 0.0469
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0458 0.0426
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0677 0.6116 1
Toxoplasma gondii hypothetical protein 0.004 0.0318 0.526
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0385 1
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0576 0.0544
Brugia malayi MGC79044 protein 0.004 0.0318 0.0286
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0133 0.1167 0.1138
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0318 0.0521
Toxoplasma gondii peptidase S15, putative 0.004 0.0318 0.526
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0458 0.0426
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0424 0.0392
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0243 0.021
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0318 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0318 0.0521
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0161 0.1417 0.1388
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1549 0.1521
Brugia malayi Cytochrome P450 family protein 0.0032 0.0243 0.021
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0133 0.1167 0.5
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.004 0.0318 0.0469
Trypanosoma cruzi amidase, putative 0.0133 0.1167 0.1864
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0576 0.0544
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0576 0.0544
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0133 0.1167 0.1138
Echinococcus granulosus fatty acid amide hydrolase 1 0.1103 1 1
Mycobacterium tuberculosis Possible lysophospholipase 0.0677 0.6116 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0677 0.6116 1
Echinococcus multilocularis transient receptor potential cation channel 0.0179 0.1582 0.1554
Brugia malayi Amidase family protein 0.0133 0.1167 0.1138
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0133 0.1167 0.1864
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0133 0.1167 0.1864
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0318 0.0521
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0318 0.0521
Toxoplasma gondii hypothetical protein 0.004 0.0318 0.526
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0178 0.1579 0.1551
Brugia malayi Protein C20orf22 0.004 0.0318 0.0286
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.004 0.0318 0.0286
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1103 1 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1549 0.1521
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1549 0.1521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0458 0.0426
Trypanosoma brucei lipase domain protein, putative 0.0161 0.1417 0.2275
Trypanosoma cruzi serine peptidase, putative 0.004 0.0318 0.0469
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0576 0.0892
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0133 0.1167 0.1138
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0133 0.1167 0.1864
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0318 0.0521
Echinococcus granulosus transient receptor potential cation channel 0.0178 0.1579 0.1551
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0424 0.7203
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0318 0.0469
Brugia malayi Lipase family protein 0.0161 0.1417 0.1388
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0458 0.0426
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.004 0.0318 0.0286
Mycobacterium ulcerans hydrolase 0.004 0.0318 0.0469
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0576 0.0892
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0424 0.0693
Echinococcus granulosus abhydrolase domain containing protein 13 0.004 0.0318 0.0286
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0424 0.0693
Echinococcus granulosus Phospholipase carboxylesterase 0.004 0.0318 0.0286
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0318 0.0521
Leishmania major hypothetical protein, conserved 0.004 0.0318 0.0469
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0677 0.6116 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0385 0.0114
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0576 0.0892
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0133 0.1167 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0576 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0576 0.0892
Plasmodium vivax PST-A protein 0.0677 0.6116 1
Toxoplasma gondii phospholipase/carboxylesterase 0.004 0.0318 0.526
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0576 0.0892
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0458 0.0426
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0677 0.6116 1
Toxoplasma gondii hypothetical protein 0.004 0.0318 0.526
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0677 0.6116 1
Echinococcus granulosus abhydrolase domain containing 3 0.004 0.0318 0.0286
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0133 0.1167 0.1864
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0424 0.7203
Mycobacterium ulcerans peptide amidase, GatA 0.0133 0.1167 0.1864
Echinococcus granulosus ankyrin repeat protein 0.0178 0.1579 0.1551
Mycobacterium ulcerans hypothetical protein 0.0677 0.6116 1
Loa Loa (eye worm) lipase 0.0161 0.1417 0.1388
Leishmania major hypothetical protein, conserved 0.0133 0.1167 0.1864
Trichomonas vaginalis lipase containing protein, putative 0.0161 0.1417 0.2316
Echinococcus multilocularis abhydrolase domain containing 3 0.004 0.0318 0.0286
Schistosoma mansoni fatty-acid amide hydrolase 0.0133 0.1167 0.1138
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0677 0.6116 1
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.004 0.0318 0.0469
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.004 0.0318 0.526
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0133 0.1167 0.1864
Plasmodium falciparum lysophospholipase, putative 0.0677 0.6116 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0318 0.0469
Leishmania major hypothetical protein, conserved 0.004 0.0318 0.0469
Trichomonas vaginalis lipase containing protein, putative 0.0161 0.1417 0.2316
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0318 0.0521
Mycobacterium ulcerans hypothetical protein 0.004 0.0318 0.0469
Schistosoma mansoni peptidase 0.004 0.0318 0.0286
Mycobacterium ulcerans amidase 0.0133 0.1167 0.1864
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.6116 1
Mycobacterium ulcerans hypothetical protein 0.004 0.0318 0.0469
Loa Loa (eye worm) acetyltransferase 0.0175 0.1549 0.1521
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0318 0.0521
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0133 0.1167 0.1864
Plasmodium falciparum lysophospholipase, putative 0.0677 0.6116 1
Echinococcus granulosus monoacylglycerol lipase abhd12 0.004 0.0318 0.0286
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0133 0.1167 0.1463
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0286
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0318 0.0521
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0318 0.0521
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0133 0.1167 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0286
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0133 0.1167 0.1138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0458 0.0426
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0576 0.0544
Echinococcus multilocularis Phospholipase carboxylesterase 0.004 0.0318 0.0286
Trypanosoma cruzi amidase, putative 0.0133 0.1167 0.1864
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0677 0.6116 1
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0318 0.0521
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0133 0.1167 0.1864
Trypanosoma cruzi monoglyceride lipase, putative 0.0677 0.6116 1
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.004 0.0318 0.0469
Echinococcus granulosus fatty acid amide hydrolase 1 0.1103 1 1
Brugia malayi MGC83647 protein 0.004 0.0318 0.0286
Toxoplasma gondii protein c14orf29, putative 0.004 0.0318 0.526
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0318 0.0521
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0286
Brugia malayi Amidase family protein 0.0133 0.1167 0.1138
Mycobacterium ulcerans amidase 0.0133 0.1167 0.1864
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1504 0.1476
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0677 0.6116 1
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0161 0.1417 0.1388
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.004 0.0318 0.0469
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.004 0.0318 0.526

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 11.22018454 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 39.81071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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