Detailed information for compound 1459573

Basic information

Technical information
  • TDR Targets ID: 1459573
  • Name: 2-(4-chlorophenyl)-N-[2-(3,4-dimethoxyphenyl) -1,3-benzoxazol-5-yl]acetamide
  • MW: 422.861 | Formula: C23H19ClN2O4
  • H donors: 1 H acceptors: 2 LogP: 4.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)c1oc2c(n1)cc(cc2)NC(=O)Cc1ccc(cc1)Cl
  • InChi: 1S/C23H19ClN2O4/c1-28-20-9-5-15(12-21(20)29-2)23-26-18-13-17(8-10-19(18)30-23)25-22(27)11-14-3-6-16(24)7-4-14/h3-10,12-13H,11H2,1-2H3,(H,25,27)
  • InChiKey: BYDLFROSZXHRPY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(4-chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)-1,3-benzoxazol-5-yl]ethanamide
  • NCGC00099051-01
  • Oprea1_323782
  • EU-0074347

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.004 0.0269 0.5019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0229 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0017 0.0011
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0405 0.0664
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0017 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0405 0.0664
Plasmodium vivax PST-A protein 0.004 0.0269 0.0441
Brugia malayi Cathepsin L-like precursor 0.002 0.009 0.009
Schistosoma mansoni peptidase 0.004 0.0269 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.1307 0.1307
Plasmodium vivax hypothetical protein, conserved 0.004 0.0269 0.0441
Loa Loa (eye worm) fibroinase 0.002 0.009 0.0085
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2544 0.4172
Trypanosoma cruzi amidase, putative 0.0132 0.1122 0.184
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0269 0.0441
Echinococcus multilocularis cysteine protease 0.002 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0017 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0526 0.0442
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0615 0.1008
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0276 0.0453
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0405 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0017 0.0017
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0269 0.0441
Trypanosoma brucei lipase domain protein, putative 0.0159 0.1371 0.2248
Toxoplasma gondii phospholipase/carboxylesterase 0.004 0.0269 0.5019
Onchocerca volvulus 0.0286 0.2546 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0237 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0671 0.6097 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.009 0.0292
Brugia malayi Cathepsin L-like precursor 0.002 0.009 0.009
Echinococcus multilocularis Phospholipase carboxylesterase 0.004 0.0269 0.0269
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0269 0.0441
Schistosoma mansoni thyroid hormone receptor 0.0164 0.142 0.142
Mycobacterium ulcerans amidase 0.0132 0.1122 0.1463
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0017 0.0011
Onchocerca volvulus 0.002 0.009 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.0159 0.1371 0.2248
Brugia malayi ecdysteroid receptor 0.0012 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Trypanosoma brucei lipase domain protein, putative 0.0159 0.1371 0.2248
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0405 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0174 0.0285
Brugia malayi Pre-SET motif family protein 0.0036 0.0237 0.0237
Leishmania major cathepsin L-like protease 0.002 0.009 0.0031
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0017 0.0017
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0132 0.1122 0.1463
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0405 0.0664
Loa Loa (eye worm) hypothetical protein 0.006 0.0455 0.0449
Mycobacterium ulcerans amidase 0.0132 0.1122 0.1463
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0276 0.0453
Brugia malayi Protein C20orf22 0.004 0.0269 0.0269
Brugia malayi Amidase family protein 0.0132 0.1122 0.1122
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.004 0.0269 0.0441
Trypanosoma brucei monoglyceride lipase, putative 0.0671 0.6097 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0526 0.0442
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0132 0.1122 0.1122
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0405 0.0405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.009 0.0148
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0671 0.6097 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0112 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0302 0.0496
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0017 0.0017
Plasmodium vivax lysophospholipase, putative 0.004 0.0269 0.0441
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0072 0.0118
Plasmodium falciparum epoxide hydrolase 2 0.004 0.0269 0.0441
Brugia malayi MH2 domain containing protein 0.0144 0.1234 0.1234
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.1307 0.1307
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0072 0.0072
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0526 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0072 0.0118
Toxoplasma gondii phospholipase 0.004 0.0269 0.5019
Schistosoma mansoni coup transcription factor 0.0012 0.0017 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0085
Giardia lamblia GTOR 0.0054 0.0405 1
Onchocerca volvulus 0.0014 0.0029 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0159 0.1371 0.1371
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0269 0.0441
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0455 0.0455
Onchocerca volvulus 0.002 0.009 0.0292
Echinococcus granulosus Phospholipase carboxylesterase 0.004 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0203 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0302 0.0496
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0017 0.0017
Echinococcus granulosus abhydrolase domain containing 3 0.004 0.0269 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0017 0.0017
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0132 0.1122 0.1463
Echinococcus multilocularis ankyrin repeat protein 0.0177 0.1534 0.1534
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.004 0.0269 0.0441
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0237 0.0237
Plasmodium vivax lysophospholipase, putative 0.004 0.0269 0.0441
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0615 0.1008
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0269 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0038 0.0063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0017 0.0017
Plasmodium vivax unspecified product 0.004 0.0269 0.0441
Plasmodium falciparum exported lipase 2 0.004 0.0269 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0302 0.0496
Toxoplasma gondii hypothetical protein 0.004 0.0269 0.5019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.02 0.0328
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0405 0.0664
Onchocerca volvulus 0.002 0.009 0.0292
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0029 0.0047
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0463 0.0759
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0303 0.0383
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0405 0.0664
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.009 0.009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0526 0.0526
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.009 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0276 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0203 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.02 0.0328
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0671 0.6097 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0553 0.0907
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0269 0.0441
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0017 0.0017
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0017 0.0017
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.009 0.0085
Plasmodium vivax lysophospholipase, putative 0.004 0.0269 0.0441
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.004 0.0269 0.0269
Brugia malayi Cathepsin L-like precursor 0.002 0.009 0.009
Plasmodium falciparum esterase, putative 0.004 0.0269 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0276 0.0453
Plasmodium vivax alpha/beta hydrolase, putative 0.004 0.0269 0.0441
Leishmania major cathepsin L-like protease 0.002 0.009 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0276 0.0453
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0174 0.0286
Plasmodium falciparum exported lipase 1 0.004 0.0269 0.0441
Trichomonas vaginalis lipase containing protein, putative 0.0159 0.1371 0.2248
Brugia malayi Pre-SET motif family protein 0.0251 0.2223 0.2223
Toxoplasma gondii hypothetical protein 0.004 0.0269 0.5019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0017 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0269 0.0441
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0017 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.002 0.009 0.009
Loa Loa (eye worm) amidase 0.0132 0.1122 0.1116
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0132 0.1122 1
Echinococcus multilocularis cysteine protease 0.002 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.1094 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0237 0.4393
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0017 0.0017
Plasmodium vivax vivapain-2 0.002 0.009 0.0148
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0029 0.0029
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0017 0.0017
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0017 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0017 0.0017
Mycobacterium ulcerans amidase 0.0132 0.1122 0.1463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0072 0.0118
Echinococcus granulosus monoacylglycerol lipase abhd12 0.004 0.0269 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0303 0.0496
Plasmodium vivax vivapain-2 0.002 0.009 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0269 0.0441
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0269 0.0441
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0017 0.0017
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.142 0.142
Echinococcus multilocularis transient receptor potential cation channel 0.0177 0.1536 0.1536
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0017 0.0017
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0405 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0269 0.0441
Schistosoma mansoni fatty-acid amide hydrolase 0.0132 0.1122 0.1122
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.004 0.0269 0.0441
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0023
Entamoeba histolytica ;Alias 0.004 0.0269 0.0441
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0072 0.0118
Schistosoma mansoni amidase 0.1094 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Brugia malayi Lipase family protein 0.0159 0.1371 0.1371
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.004 0.0269 0.0327
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0072 0.0072
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Schistosoma mansoni fatty-acid amide hydrolase 0.1094 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.004 0.0269 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0017 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0302 0.0496
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0132 0.1122 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0237 0.0237
Plasmodium vivax SET domain protein, putative 0.0036 0.0237 0.0388
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2223 0.2219
Schistosoma mansoni thyroid hormone receptor 0.0164 0.142 0.142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0237 0.0237
Leishmania major cathepsin L-like protease 0.0077 0.0615 0.0901
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0269 0.0441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.009 0.0148
Echinococcus multilocularis abhydrolase domain containing 3 0.004 0.0269 0.0269
Brugia malayi nuclear receptor NHR-88 0.0012 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0276 0.0453
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0269 0.0441
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0269 0.0441
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0405 0.0399
Loa Loa (eye worm) ctsf protein 0.002 0.009 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0017 0.0017
Leishmania major cathepsin L-like protease 0.002 0.009 0.0031
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0132 0.1122 0.1463
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0526 0.0526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0331 0.0544
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0017 0.0017
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0615 0.1008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0017 0.0011
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.009 0.009
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0615 0.1008
Brugia malayi cathepsin L-like precursor 0.0014 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0276 0.0453
Plasmodium falciparum prodrug activation and resistance esterase 0.004 0.0269 0.0441
Echinococcus granulosus cathepsin l1 0.002 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0269 0.0441
Brugia malayi MGC83647 protein 0.004 0.0269 0.0269
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0671 0.6097 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0017 0.0017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0526 0.0526
Leishmania major cysteine peptidase A (CPA) 0.002 0.009 0.0031
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0269 0.0441
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0269 0.0441
Echinococcus granulosus cathepsin l1 0.0014 0.0029 0.0029
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0132 0.1122 0.184
Onchocerca volvulus 0.002 0.009 0.0292
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.009 0.0148
Brugia malayi Cathepsin L-like precursor 0.002 0.009 0.009
Plasmodium falciparum esterase, putative 0.004 0.0269 0.0441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0017 0.0017
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0072 0.0072
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0132 0.1122 0.1122
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0017 0.0017
Brugia malayi Cathepsin L-like precursor 0.0014 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0269 0.0441
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.004 0.0269 0.5019
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.009 0.0148
Trypanosoma cruzi monoglyceride lipase, putative 0.0671 0.6097 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0405 0.0405
Plasmodium vivax alpha/beta hydrolase, putative 0.004 0.0269 0.0441
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0405 0.0664
Plasmodium falciparum lysophospholipase, putative 0.004 0.0269 0.0441
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.009 0.009
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0671 0.6097 1
Loa Loa (eye worm) amidase 0.0132 0.1122 0.1116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0017 0.0017
Leishmania major cathepsin L-like protease 0.0077 0.0615 0.0901
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0017 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0671 0.6097 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.009 0.0148
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0237 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Loa Loa (eye worm) hypothetical protein 0.004 0.0269 0.0263
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0017 0.0017
Mycobacterium ulcerans hypothetical protein 0.0671 0.6097 1
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.004 0.0269 0.5019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0009 0.0015
Echinococcus granulosus transient receptor potential cation channel 0.0177 0.1534 0.1534
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.004 0.0269 0.5019
Leishmania major cathepsin L-like protease 0.002 0.009 0.0031
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0269 0.0441
Schistosoma mansoni hypothetical protein 0.0152 0.1307 0.1307
Echinococcus granulosus abhydrolase domain containing protein 13 0.004 0.0269 0.0269
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0269 0.0441
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.004 0.0269 0.0269
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.009 0.0148
Toxoplasma gondii hypothetical protein 0.004 0.0269 0.5019
Entamoeba histolytica cysteine proteinase, putative 0.002 0.009 0.0148
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0132 0.1122 0.1122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.009 0.0148
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0269 0.0441
Leishmania major hypothetical protein, conserved 0.004 0.0269 0.0327
Brugia malayi Amidase family protein 0.0132 0.1122 0.1122
Mycobacterium ulcerans lysophospholipase 0.0671 0.6097 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0174 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.009 0.0148
Brugia malayi MGC79044 protein 0.004 0.0269 0.0269
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.009 0.0148
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0029 0.0047
Plasmodium vivax PST-A protein 0.004 0.0269 0.0441
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.004 0.0269 0.0441
Plasmodium vivax PST-A protein 0.004 0.0269 0.0441
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.009 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0526 0.0442
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0526 0.0755
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0132 0.1122 0.1463
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0177 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0017 0.0017
Onchocerca volvulus 0.006 0.0455 0.1734
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0269 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0203 0.0333
Plasmodium falciparum lysophospholipase, putative 0.0671 0.6097 1
Plasmodium vivax unspecified product 0.004 0.0269 0.0441
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0671 0.6097 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0405 0.0552
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0132 0.1122 0.184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0174 0.0285
Mycobacterium ulcerans peptide amidase, GatA 0.0132 0.1122 0.1463
Leishmania major hypothetical protein, conserved 0.0159 0.1371 0.2156
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0671 0.6097 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1094 1 1
Plasmodium falciparum alpha/beta-hydrolase, putative 0.004 0.0269 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0072 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0174 0.0286
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0671 0.6097 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0224 0.0224
Entamoeba histolytica hypothetical protein 0.004 0.0269 0.0441
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0141 0.0231
Leishmania major hypothetical protein, conserved 0.004 0.0269 0.0327
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0269 0.0441
Brugia malayi putative amidase 0.0132 0.1122 0.1122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.009 0.0148
Entamoeba histolytica cysteine protease, putative 0.002 0.009 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0017 0.0017
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1234 0.1229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.0159 0.1371 0.2248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.004 0.0269 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0269 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0029 0.0047
Trypanosoma brucei monoglyceride lipase, putative 0.0671 0.6097 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0269 0.0441
Loa Loa (eye worm) cysteine protease 0.002 0.009 0.0085
Plasmodium falciparum lysophospholipase, putative 0.0671 0.6097 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0017 0.0017
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0671 0.6097 1
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.004 0.0269 0.0269
Plasmodium vivax hypothetical protein, conserved 0.004 0.0269 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.024 0.0393
Trypanosoma cruzi serine peptidase, putative 0.004 0.0269 0.0441
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0405 0.0405
Brugia malayi steroid hormone receptor 0.0012 0.0017 0.0017
Echinococcus granulosus fatty acid amide hydrolase 1 0.1094 1 1
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0159 0.1371 0.1371
Entamoeba histolytica hypothetical protein 0.004 0.0269 0.0441
Loa Loa (eye worm) hypothetical protein 0.004 0.0269 0.0263
Leishmania major cathepsin L-like protease 0.002 0.009 0.0031
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1234 0.1229
Trypanosoma cruzi serine peptidase, putative 0.004 0.0269 0.0441
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0526 0.0526
Trichomonas vaginalis lipase containing protein, putative 0.0159 0.1371 0.2248
Mycobacterium ulcerans amidase 0.0132 0.1122 0.1463
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0072 0.0118
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0017 0.0017
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0526 0.0442
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.009 0.0148
Loa Loa (eye worm) hypothetical protein 0.0036 0.0237 0.0231
Plasmodium vivax PST-A protein 0.004 0.0269 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.009 0.0148
Leishmania major monoglyceride lipase, putative 0.0671 0.6097 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0017 0.0017
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0132 0.1122 0.1463
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0029 0.0029
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0072 0.0118
Plasmodium vivax PST-A protein 0.004 0.0269 0.0441
Onchocerca volvulus 0.0159 0.1371 0.5353
Plasmodium falciparum lysophospholipase, putative 0.0671 0.6097 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.009 0.0085
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.004 0.0269 0.0441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0302 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0269 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0174 0.0285
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0072 0.0118
Onchocerca volvulus 0.002 0.009 0.0292
Onchocerca volvulus 0.0036 0.0237 0.087
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0132 0.1122 0.5
Mycobacterium ulcerans amidase 0.0132 0.1122 0.1463
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.009 0.009
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1094 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.009 0.0148
Trypanosoma cruzi amidase, putative 0.0132 0.1122 0.184
Brugia malayi Cathepsin L-like precursor 0.0014 0.0029 0.0029
Leishmania major hypothetical protein, conserved 0.0132 0.1122 0.1742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0072 0.0118
Onchocerca volvulus Cathepsin L homolog 0.002 0.009 0.0292
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0017 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0405 0.0405
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0276 0.5163
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0671 0.6097 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0017 0.0011
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0132 0.1122 0.184
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0269 0.0441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0615 0.1008
Toxoplasma gondii peptidase S15, putative 0.004 0.0269 0.5019
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0132 0.1122 0.1463
Onchocerca volvulus Cathepsin F homolog 0.002 0.009 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0405 0.0664
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0269 0.0441
Mycobacterium tuberculosis Possible lysophospholipase 0.0671 0.6097 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0017 0.0017
Leishmania major cathepsin L-like protease 0.0077 0.0615 0.0901
Brugia malayi nuclear hormone receptor 0.0012 0.0017 0.0017
Onchocerca volvulus 0.002 0.009 0.0292
Echinococcus granulosus ankyrin repeat protein 0.0177 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Brugia malayi Cathepsin L-like precursor 0.002 0.009 0.009
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.009 0.0148
Entamoeba histolytica cysteine proteinase, putative 0.002 0.009 0.0148
Brugia malayi Cathepsin L-like precursor 0.002 0.009 0.009
Plasmodium falciparum lysophospholipase, putative 0.004 0.0269 0.0441
Toxoplasma gondii cathepsin CPL 0.002 0.009 0.1568
Plasmodium falciparum esterase, putative 0.0671 0.6097 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0269 0.0263
Onchocerca volvulus 0.002 0.009 0.0292
Echinococcus granulosus fatty acid amide hydrolase 1 0.0132 0.1122 0.1122
Loa Loa (eye worm) lipase 0.0159 0.1371 0.1366
Echinococcus multilocularis tumor protein p63 0.0408 0.367 0.367
Plasmodium vivax PST-A protein 0.0671 0.6097 1
Plasmodium falciparum BEM46-like protein, putative 0.004 0.0269 0.0441
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0017 0.0017
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0132 0.1122 0.1122
Echinococcus granulosus fatty acid amide hydrolase 1 0.1094 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0303 0.0496
Loa Loa (eye worm) hypothetical protein 0.004 0.0269 0.0263
Echinococcus granulosus tumor protein p63 0.0408 0.367 0.367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.009 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0174 0.0286
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0072 0.0066
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.004 0.0269 0.0441
Toxoplasma gondii protein c14orf29, putative 0.004 0.0269 0.5019

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2818 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2885 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 4.14 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 11.6681 uM PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.6892 uM PubChem BioAssay. InCell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.6892 uM PubChem BioAssay. InCell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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