Detailed information for compound 1459584

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 725.825 | Formula: C45H43NO8
  • H donors: 5 H acceptors: 6 LogP: 7.41 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@]2(O)C#CCCCCNC(=O)c1ccc2c(c1)C(=O)OC12c2ccc(cc2Oc2c1ccc(c2)O)O)C
  • InChi: 1S/C45H43NO8/c1-43-19-16-32-31-12-8-28(47)22-26(31)6-11-33(32)35(43)17-20-44(43,52)18-4-2-3-5-21-46-41(50)27-7-13-36-34(23-27)42(51)54-45(36)37-14-9-29(48)24-39(37)53-40-25-30(49)10-15-38(40)45/h7-10,12-15,22-25,32-33,35,47-49,52H,2-3,5-6,11,16-17,19-21H2,1H3,(H,46,50)/t32-,33-,35+,43+,44+/m1/s1
  • InChiKey: HHTHBSSZDQPKQS-GGGSTFROSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0014 0.0085 0.0585
Leishmania major cytochrome p450-like protein 0.0033 0.0585 0.4147
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.092 0.632
Plasmodium falciparum glutathione reductase 0.0046 0.092 0.6535
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.1406 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0589 0.2023
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0033 0.0585 0.3784
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0085 0.03
Loa Loa (eye worm) hypothetical protein 0.0015 0.0132 0.0453
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0147 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0881 0.1074
Toxoplasma gondii thioredoxin reductase 0.0046 0.092 0.0917
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0033 0.0585 0.2129
Echinococcus granulosus GPCR family 2 0.0015 0.0132 0.016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0147 0.1026
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.022 0.1546
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1012 0.719
Loa Loa (eye worm) hypothetical protein 0.0051 0.1029 0.3545
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0147 0.0469
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0147 0.1026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.022 0.1021
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0033 0.0585 0.3784
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.092 0.1121
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0147 0.0144
Loa Loa (eye worm) hypothetical protein 0.0046 0.0922 0.3176
Echinococcus multilocularis expressed conserved protein 0.009 0.2046 0.2493
Onchocerca volvulus 0.0014 0.0085 0.0585
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0132 0.016
Schistosoma mansoni hypothetical protein 0.0033 0.0589 0.0715
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0922 0.3157
Schistosoma mansoni hypothetical protein 0.0033 0.0585 0.0709
Plasmodium vivax pyruvate kinase, putative 0.0065 0.1406 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.092 0.6535
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0085 0.03
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0003 0.001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0147 0.0576
Echinococcus multilocularis dna polymerase kappa 0.0019 0.022 0.0268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0147 0.0469
Plasmodium falciparum pyruvate kinase 0.0065 0.1406 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0594 0.0723
Echinococcus multilocularis protein patched 0.0041 0.0792 0.0965
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0147 0.0469
Mycobacterium leprae Conserved hypothetical protein 0.0033 0.0585 0.1885
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0033 0.0585 0.3784
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0132 0.016
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0033 0.0585 0.3784
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.2195 0.2675
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0033 0.0585 0.3784
Plasmodium falciparum thioredoxin reductase 0.0016 0.0147 0.1026
Trypanosoma brucei unspecified product 0.0019 0.022 0.1121
Echinococcus multilocularis dna polymerase eta 0.0019 0.022 0.0268
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0622 0.4415
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.022 0.1121
Schistosoma mansoni hypothetical protein 0.0015 0.0132 0.0157
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0792 0.2727
Chlamydia trachomatis pyruvate kinase 0.0065 0.1406 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0033 0.0585 0.2129
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0085 0.0585
Schistosoma mansoni hypothetical protein 0.0015 0.0132 0.0157
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0033 0.0585 0.3784
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1012 0.7015
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.2435 0.8898
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0033 0.0585 0.3784
Schistosoma mansoni hypothetical protein 0.0015 0.0132 0.0157
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0147 0.1026
Leishmania major cytochrome p450-like protein 0.0033 0.0585 0.4147
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0922 0.3169
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0003 0.0004
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.1406 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0085 0.03
Brugia malayi glutathione reductase 0.0046 0.092 0.3162
Echinococcus multilocularis pyruvate kinase 0.0065 0.1406 0.1713
Echinococcus multilocularis 0.0033 0.0585 0.0713
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.022 0.1546
Loa Loa (eye worm) hypothetical protein 0.0041 0.0792 0.2727
Toxoplasma gondii pyruvate kinase PyK1 0.0065 0.1406 0.1403
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0085 0.0283
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0622 0.4415
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1121
Brugia malayi TAR-binding protein 0.0124 0.2903 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1121
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1121
Brugia malayi Pyruvate kinase, M2 isozyme 0.0065 0.1406 0.4838
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0881 0.1074
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0922 0.6336
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0033 0.0585 0.2129
Schistosoma mansoni hypothetical protein 0.004 0.0754 0.0915
Loa Loa (eye worm) TAR-binding protein 0.0124 0.2903 1
Trypanosoma brucei pyruvate kinase 1 0.0065 0.1406 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0033 0.0585 0.3784
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.3249 0.396
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2903 0.3535
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0033 0.0585 0.2129
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0085 0.0585
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0132 0.016
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.022 0.0793
Schistosoma mansoni DNA polymerase eta 0.0019 0.022 0.0264
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0003 0.0004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0147 0.0469
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0594 0.0591
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.022 0.1121
Loa Loa (eye worm) cytochrome P450 0.0033 0.0585 0.2014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0881 0.3029
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0147 0.1026
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0792 0.0965
Brugia malayi CHE-14 protein 0.0041 0.0792 0.272
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0147 0.0576
Loa Loa (eye worm) RNA binding protein 0.0124 0.2903 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0984 0.339
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0147 0.0469
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0033 0.0585 0.3784
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1121
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.022 0.1021
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0038 0.0121
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.1406 1
Echinococcus multilocularis tar DNA binding protein 0.0124 0.2903 0.3538
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0085 0.0585
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0085 0.0374
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.1406 1
Echinococcus granulosus pyruvate kinase 0.0065 0.1406 0.1713
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0033 0.0585 0.3784
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.1012 0.7015
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0922 0.6336
Loa Loa (eye worm) hypothetical protein 0.0014 0.0085 0.0293
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0574 0.2089
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0033 0.0585 0.3784
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.001
Echinococcus multilocularis pyruvate kinase 0.0034 0.0594 0.0723
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.1406 1
Schistosoma mansoni pyruvate kinase 0.0065 0.1406 0.171
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.022 0.1021
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.1012 0.7015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0922 0.3362
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0003 0.001
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0003 0.0004
Brugia malayi Cytochrome P450 family protein 0.0033 0.0585 0.2006
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.092 0.3169
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0132 0.0444
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.1012 0.1233
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1121
Loa Loa (eye worm) pyruvate kinase-PB 0.0046 0.0901 0.3104
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0085 0.03
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0033 0.0585 0.3784
Loa Loa (eye worm) glutathione reductase 0.0046 0.092 0.3169
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0033 0.0585 0.3784
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0922 0.6336
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0147 0.0469
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.092 0.1121
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0085 0.0112
Brugia malayi RNA binding protein 0.0124 0.2903 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.0585 0.3784
Echinococcus granulosus mitogen activated protein kinase 0.005 0.1012 0.1233
Schistosoma mansoni hypothetical protein 0.0015 0.0132 0.0157
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.022 0.0268
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0881 0.3036
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0033 0.0585 0.2129
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0574 0.2089
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0085 0.03
Brugia malayi Pyruvate kinase, muscle isozyme 0.0065 0.1406 0.4838
Trypanosoma brucei pyruvate kinase 1, putative 0.0065 0.1406 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0037 0.0123
Echinococcus granulosus geminin 0.0331 0.8206 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0033 0.0585 0.2129
Loa Loa (eye worm) pyruvate kinase 0.0065 0.1406 0.4843
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.1012 0.7049
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0033 0.0585 0.2129
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0085 0.0293
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0085 0.0103
Loa Loa (eye worm) pyruvate kinase 0.0014 0.0089 0.0305
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0003 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0147 0.0469
Echinococcus multilocularis pyruvate kinase 0.0052 0.1054 0.1285
Echinococcus granulosus expressed conserved protein 0.009 0.2046 0.2493
Giardia lamblia DINP protein human, muc B family 0.0019 0.022 0.0579
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0003 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.022 0.1121
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0922 0.6336
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.022 0.1021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0922 0.4193
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.2736 1
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0003 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0922 0.655
Brugia malayi Cytochrome P450 family protein 0.0033 0.0585 0.2006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.2903 1
Brugia malayi pyruvate kinase 0.0014 0.0089 0.0296
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0585 0.3784
Treponema pallidum NADH oxidase 0.0016 0.0147 0.5
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0033 0.0585 0.3853
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0038 0.0121
Schistosoma mansoni patched 1 0.0041 0.0792 0.0962
Loa Loa (eye worm) hypothetical protein 0.0019 0.022 0.0757
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0147 0.1026
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0033 0.0585 0.3784
Onchocerca volvulus 0.0014 0.0085 0.0585
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0147 0.1026
Mycobacterium tuberculosis Probable reductase 0.0106 0.2435 0.8898
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0085 0.0283
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0033 0.0585 0.3784
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0132 0.0453
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0922 0.3362
Brugia malayi MAP kinase sur-1 0.005 0.1012 0.3478
Loa Loa (eye worm) hypothetical protein 0.0014 0.0085 0.0293
Echinococcus granulosus pyruvate kinase 0.0065 0.1406 0.1713
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0085 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1121
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0033 0.0585 0.2129
Loa Loa (eye worm) hypothetical protein 0.0046 0.0922 0.3176
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1121
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0622 0.2266
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0922 0.4193
Giardia lamblia Pyruvate kinase 0.0034 0.0594 0.3548
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.2195 0.7558
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.022 0.0793
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0033 0.0585 0.2129
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0147 0.0469
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0033 0.0585 0.3784
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0574 0.2089
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.2435 0.8898
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.0089 0.0296
Echinococcus granulosus pyruvate kinase 0.0034 0.0594 0.0723
Loa Loa (eye worm) oxidoreductase 0.0014 0.0085 0.0293
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0085 0.0283
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0033 0.0585 0.3784
Entamoeba histolytica pyruvate kinase, putative 0.0046 0.0901 0.4097
Echinococcus multilocularis geminin 0.0331 0.8206 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0033 0.0585 0.2129
Loa Loa (eye worm) CYP4Cod1 0.0033 0.0585 0.2014
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0147 0.0176
Schistosoma mansoni cytochrome P450 0.0033 0.0585 0.0709
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0147 0.1026
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2903 0.3535
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0922 0.655
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.022 0.0264
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0033 0.0585 0.2129
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0147 0.0144
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0922 0.3169
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0585 0.2014
Leishmania major DNA polymerase kappa, putative 0.0019 0.022 0.1546
Onchocerca volvulus 0.0046 0.0922 0.655
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0033 0.0585 0.2129
Loa Loa (eye worm) hypothetical protein 0.0033 0.0589 0.2031
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0147 0.1026
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.022 0.0264
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.092 0.3355
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.2233 0.2718
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0922 0.6336
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0922 0.4193
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.2736 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0574 0.2089
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1121
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0003 0.0004
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0085 0.0293
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.022 0.1121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0881 0.1071
Schistosoma mansoni hypothetical protein 0.004 0.0754 0.0915
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0147 0.0469
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.1012 0.7015
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.092 0.6535
Echinococcus multilocularis protein dispatched 1 0.0047 0.0941 0.1146
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.022 0.0748
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0147 0.1026
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0085 0.0082
Echinococcus granulosus cytochrome P450 2K1 0.0033 0.0585 0.0713
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2903 0.3535
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0147 0.5
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0033 0.0585 0.3784
Leishmania major pyruvate kinase 0.0065 0.1406 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0922 0.655
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0033 0.0585 0.2129
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.3249 0.396
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1012 0.719
Brugia malayi cytochrome P450 0.0033 0.0585 0.2006
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0085 0.0585
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0003 0.0004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.2736 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0033 0.0585 0.4147
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0792 0.5622
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2903 0.3535
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.2435 0.8898
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1012 0.719
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0585 0.2014
Schistosoma mansoni hypothetical protein 0.004 0.0754 0.0915
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0984 0.3383
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0085 0.0103
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0622 0.4415
Schistosoma mansoni hypothetical protein 0.0331 0.8206 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0922 0.3157
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0147 0.0179
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0085 0.0585
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0622 0.4069
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0594 0.421
Mycobacterium leprae Probable pyruvate kinase PykA 0.0065 0.1406 0.4982
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.0585 0.3784
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0085 0.0283
Schistosoma mansoni pyruvate kinase 0.0034 0.0594 0.072
Echinococcus multilocularis pyruvate kinase 0.0034 0.0594 0.0723
Loa Loa (eye worm) hypothetical protein 0.0035 0.0622 0.2144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.022 0.1021
Schistosoma mansoni serine/threonine protein kinase 0.005 0.1012 0.123
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.022 0.0268
Giardia lamblia Pyruvate kinase 0.0065 0.1406 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.1012 0.719
Leishmania major trypanothione reductase 0.0046 0.092 0.6535
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.022 0.1546
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0922 0.3169
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0922 0.6336
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.2435 0.8864
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.022 0.0989
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0147 0.0179
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0003 0.0004
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0033 0.0585 0.3784
Loa Loa (eye worm) hypothetical protein 0.0046 0.0901 0.3104
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0033 0.0585 0.2129
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.2195 1
Trypanosoma brucei trypanothione reductase 0.0046 0.092 0.6362
Loa Loa (eye worm) hypothetical protein 0.0096 0.2195 0.756
Echinococcus multilocularis GPCR, family 2 0.0015 0.0132 0.016
Echinococcus granulosus dna polymerase eta 0.0019 0.022 0.0268
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.1012 0.719
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0147 0.1026
Trypanosoma brucei cytochrome P450, putative 0.0033 0.0585 0.3853
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.2435 0.8898
Mycobacterium ulcerans hypothetical protein 0.0046 0.0922 0.6336
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0085 0.01
Plasmodium falciparum glutathione reductase 0.0016 0.0147 0.1026
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0085 0.0585
Echinococcus multilocularis pyruvate kinase 0.0065 0.1406 0.1713
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0147 0.0469
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0085 0.0283
Leishmania major DNA polymerase eta, putative 0.0019 0.022 0.1546
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0003 0.0004
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0003 0.0004
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0085 0.03
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0147 0.0469
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.1012 0.3485
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0033 0.0585 0.3784
Schistosoma mansoni hypothetical protein 0.0331 0.8206 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0033 0.0585 0.2129
Trypanosoma brucei protein kinase, putative 0.005 0.1012 0.7049
Mycobacterium leprae putative cytochrome p450 0.0033 0.0585 0.1885
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.1406 1
Mycobacterium ulcerans pyruvate kinase 0.0065 0.1406 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0085 0.03
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.022 0.0757
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0984 0.3383
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.1012 0.1233
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0922 0.6336
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0147 0.0576
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0003 0.0004
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0792 0.0965
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0033 0.0585 0.2129
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0033 0.0585 0.2129
Onchocerca volvulus 0.0014 0.0085 0.0585
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.1406 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0585 0.2014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0881 0.1071
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0033 0.0585 0.2129
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.001
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.2195 0.2675
Loa Loa (eye worm) hypothetical protein 0.0049 0.0984 0.339
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1121
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.0585 0.3784
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.022 0.1121
Loa Loa (eye worm) hypothetical protein 0.0035 0.0622 0.2144
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0085 0.03
Loa Loa (eye worm) hypothetical protein 0.0035 0.0622 0.2144
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0065 0.1406 0.5133
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0147 0.0497
Echinococcus granulosus pyruvate kinase 0.0034 0.0594 0.0723
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.1012 0.1009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0881 0.1074
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0085 0.03
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0033 0.0585 0.3784
Loa Loa (eye worm) hypothetical protein 0.0035 0.0622 0.2144
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0085 0.0082
Echinococcus granulosus dna polymerase kappa 0.0019 0.022 0.0268
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.1012 0.1233
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0003 0.0004
Leishmania major cytochrome p450-like protein 0.0033 0.0585 0.4147
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0085 0.03
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0085 0.0112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0881 0.1071
Plasmodium falciparum thioredoxin reductase 0.0046 0.092 0.6535
Echinococcus granulosus pyruvate kinase 0.0034 0.0594 0.0723
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.2903 1
Brugia malayi Thioredoxin reductase 0.0046 0.092 0.3162
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0033 0.0585 0.2129
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0147 0.0576
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.022 0.1021
Schistosoma mansoni hypothetical protein 0.004 0.0754 0.0915
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0881 0.1074
Schistosoma mansoni pyruvate kinase 0.0065 0.1406 0.171
Loa Loa (eye worm) pyruvate kinase 0.0065 0.1406 0.4843
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.022 0.1021
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0085 0.0283
Echinococcus granulosus tar DNA binding protein 0.0124 0.2903 0.3538
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.2736 1
Brugia malayi Cytochrome P450 family protein 0.0033 0.0585 0.2006
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0003 0.0004
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0085 0.0082
Loa Loa (eye worm) hypothetical protein 0.0065 0.1406 0.4843
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2903 0.3535
Trichomonas vaginalis CMGC family protein kinase 0.005 0.1012 0.719
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0594 0.421
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0585 0.3784
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0147 0.1026
Giardia lamblia Kinase, CMGC MAPK 0.005 0.1012 0.6868
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0792 0.0965
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0085 0.0585
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0132 0.0444
Leishmania major pyruvate kinase 0.0065 0.1406 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0033 0.0585 0.2129
Brugia malayi Cytochrome P450 family protein 0.0033 0.0585 0.2006
Loa Loa (eye worm) hypothetical protein 0.0046 0.0922 0.3176
Loa Loa (eye worm) pyruvate kinase 0.0065 0.1406 0.4843
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0242 0.0824
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0147 0.0469
Loa Loa (eye worm) hypothetical protein 0.0035 0.0622 0.2144
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0147 0.0527
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0132 0.016
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.022 0.0748
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.2435 0.8898

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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