Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus anthracis | Anthrax lethal factor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lozenge | 0.0064 | 0.0458 | 0.1218 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0315 | 0.3763 | 1 |
Echinococcus multilocularis | Protein lozenge | 0.0064 | 0.0458 | 0.0458 |
Brugia malayi | RNA binding protein | 0.0073 | 0.0576 | 0.0912 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.4039 | 1 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0117 | 0.1159 | 0.3081 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0164 | 0.1777 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0336 | 0.4039 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0054 | 0.0086 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.031 | 0.049 |
Onchocerca volvulus | 0.0231 | 0.2651 | 0.4196 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.0576 | 0.0912 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.031 | 0.0823 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.0576 | 0.0912 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.031 | 0.0823 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0315 | 0.3763 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.2282 | 0.3613 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.031 | 0.0823 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0315 | 0.3763 | 0.3763 |
Loa Loa (eye worm) | runx1 | 0.0064 | 0.0458 | 0.0725 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.2282 | 0.3613 |
Onchocerca volvulus | 0.051 | 0.6318 | 1 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.4039 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0256 | 0.0405 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0576 | 0.1531 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0117 | 0.1159 | 0.3081 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0576 | 0.1531 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.4039 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0315 | 0.3763 | 0.5956 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0336 | 0.4039 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0336 | 0.4039 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.031 | 0.049 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.0576 | 0.0912 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.031 | 0.0823 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0256 | 0.0405 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.0576 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 0.6318 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.4039 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0054 | 0.0144 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.0576 | 0.0576 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.031 | 0.031 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0315 | 0.3763 | 0.5956 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0164 | 0.1777 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 0.6318 | 1 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.0576 | 0.0912 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0576 | 0.1531 |
Leishmania major | 0.0315 | 0.3763 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0576 | 0.1531 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0315 | 0.3763 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0315 | 0.3763 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0054 | 0.0086 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0315 | 0.3763 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0256 | 0.0405 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.031 | 0.0823 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0256 | 0.0405 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0336 | 0.4039 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0576 | 0.1531 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0164 | 0.1777 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.4039 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.4039 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.4039 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.4039 | 1 |
Brugia malayi | hypothetical protein | 0.051 | 0.6318 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.031 | 0.031 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0315 | 0.3763 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.0576 | 0.0912 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.