Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0264 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0264 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0264 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0264 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0228 | 0.8115 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0264 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0264 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0264 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0264 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.