Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.1555 | 0.1501 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0459 | 0.1555 | 0.1555 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0459 | 0.1555 | 0.1555 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0459 | 0.1555 | 0.1555 |
Onchocerca volvulus | 0.0459 | 0.1555 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0459 | 0.1555 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.1555 | 0.1501 |
Brugia malayi | Carboxylesterase family protein | 0.0459 | 0.1555 | 0.1555 |
Echinococcus granulosus | neuroligin | 0.0459 | 0.1555 | 0.1555 |
Brugia malayi | hypothetical protein | 0.0459 | 0.1555 | 0.1555 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0459 | 0.1555 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0459 | 0.1555 | 0.1555 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0459 | 0.1555 | 0.5 |
Onchocerca volvulus | 0.0459 | 0.1555 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0459 | 0.1555 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2716 | 1 | 1 |
Onchocerca volvulus | 0.0459 | 0.1555 | 0.5 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0459 | 0.1555 | 0.1555 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0459 | 0.1555 | 0.1555 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0459 | 0.1555 | 0.5 |
Onchocerca volvulus | 0.0459 | 0.1555 | 0.5 | |
Onchocerca volvulus | 0.0459 | 0.1555 | 0.5 | |
Schistosoma mansoni | gliotactin | 0.0459 | 0.1555 | 0.1555 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.1555 | 0.1501 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0459 | 0.1555 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.1555 | 0.1501 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0459 | 0.1555 | 0.1501 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0063 | 0.0063 |
Schistosoma mansoni | acetylcholinesterase | 0.0459 | 0.1555 | 0.1555 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0459 | 0.1555 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2716 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0459 | 0.1555 | 0.1555 |
Echinococcus multilocularis | acetylcholinesterase | 0.2716 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0459 | 0.1555 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.2716 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0459 | 0.1555 | 0.1501 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0459 | 0.1555 | 0.1555 |
Echinococcus multilocularis | acetylcholinesterase | 0.2716 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.1555 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.1555 | 0.1501 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0459 | 0.1555 | 0.1555 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0063 | 0.0063 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2716 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2716 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0459 | 0.1555 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.2716 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2716 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2716 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2716 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0459 | 0.1555 | 0.1555 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0459 | 0.1555 | 0.1555 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.1555 | 0.1501 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0459 | 0.1555 | 0.1555 |
Echinococcus granulosus | acetylcholinesterase | 0.2716 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.8048 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (binding) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: Confirmation Assay for Identification of Novel General Anesthetics. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2323, AID2385, AID485281] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.