Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Streptococcus pyogenes serotype M1 | Streptokinase A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0223 | 0.1422 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.1321 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1321 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1321 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1321 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1321 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1422 | 0.1422 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1422 | 0.1422 |
Leishmania major | basic transcription factor 3a, putative | 0.0042 | 0.0008 | 0.5 |
Brugia malayi | hypothetical protein | 0.0223 | 0.1422 | 0.1422 |
Echinococcus granulosus | carboxylesterase 5A | 0.1321 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0223 | 0.1422 | 0.1415 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0149 | 0.0149 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0042 | 0.0008 | 0.5 |
Toxoplasma gondii | NAC domain-containing protein | 0.0042 | 0.0008 | 0.5 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0042 | 0.0008 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0223 | 0.1422 | 0.1415 |
Brugia malayi | Carboxylesterase family protein | 0.0223 | 0.1422 | 0.1422 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0223 | 0.1422 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1422 | 0.1422 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0223 | 0.1422 | 0.5 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.0008 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1321 | 1 | 1 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0042 | 0.0008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1909 | 0.1909 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0149 | 0.0149 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1422 | 0.1422 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1422 | 0.1422 |
Onchocerca volvulus | 0.0223 | 0.1422 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1422 | 0.1422 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0134 | 0.0134 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1321 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0223 | 0.1422 | 0.1422 |
Echinococcus granulosus | geminin | 0.0205 | 0.1277 | 0.127 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0223 | 0.1422 | 0.1422 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1422 | 0.1422 |
Schistosoma mansoni | acetylcholinesterase | 0.0223 | 0.1422 | 0.1422 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0223 | 0.1422 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0223 | 0.1422 | 0.1422 |
Echinococcus granulosus | acetylcholinesterase | 0.1321 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0134 | 0.0134 |
Schistosoma mansoni | gliotactin | 0.0223 | 0.1422 | 0.1422 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1277 | 0.127 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0223 | 0.1422 | 0.1422 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0223 | 0.1422 | 0.1415 |
Echinococcus multilocularis | acetylcholinesterase | 0.1321 | 1 | 1 |
Onchocerca volvulus | 0.0223 | 0.1422 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1321 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1321 | 1 | 1 |
Loa Loa (eye worm) | ICD-1 protein | 0.0042 | 0.0008 | 0.0008 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.1909 | 0.1903 |
Loa Loa (eye worm) | carboxylesterase | 0.0223 | 0.1422 | 0.1422 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0134 | 0.0134 |
Schistosoma mansoni | transcription factor btf3 | 0.0042 | 0.0008 | 0.0008 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.1909 | 0.1903 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1277 | 0.1277 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0223 | 0.1422 | 0.1415 |
Onchocerca volvulus | 0.0223 | 0.1422 | 1 | |
Brugia malayi | hypothetical protein | 0.0286 | 0.1909 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0149 | 0.0149 |
Brugia malayi | Carboxylesterase family protein | 0.0223 | 0.1422 | 0.1422 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0008 | 0.5 |
Onchocerca volvulus | 0.0223 | 0.1422 | 1 | |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0042 | 0.0008 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1277 | 0.1277 |
Onchocerca volvulus | 0.0223 | 0.1422 | 1 | |
Brugia malayi | beta-NAC-like protein | 0.0042 | 0.0008 | 0.0008 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0223 | 0.1422 | 0.1422 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0223 | 0.1422 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0223 | 0.1422 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0223 | 0.1422 | 0.1415 |
Brugia malayi | Carboxylesterase family protein | 0.0223 | 0.1422 | 0.1422 |
Loa Loa (eye worm) | carboxylesterase | 0.0223 | 0.1422 | 0.1422 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0223 | 0.1422 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.7329 | 0.7327 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0223 | 0.1422 | 0.1415 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.0008 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0223 | 0.1422 | 0.1422 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0223 | 0.1422 | 0.1415 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 6.273 um | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] | ChEMBL. | No reference |
EC50 (functional) | > 50 um | PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.3225 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.99 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (binding) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.