Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2561 | 0.2561 |
Onchocerca volvulus | 0.0033 | 0.2561 | 0.5 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.246 | 0.246 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.724 | 0.724 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4015 | 0.3848 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2561 | 0.2561 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2561 | 0.2561 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2561 | 0.2353 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4015 | 0.4015 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2561 | 0.2353 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.4015 | 0.4015 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2561 | 0.2353 |
Schistosoma mansoni | lamin | 0.0033 | 0.2561 | 0.2353 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2561 | 0.2353 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2561 | 0.2561 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2561 | 0.2353 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.724 | 0.724 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0271 | 0.0271 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0271 | 0.0271 |
Onchocerca volvulus | 0.0033 | 0.2561 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.2561 | 0.2353 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2561 | 0.2561 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.724 | 0.724 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2561 | 0.2353 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.724 | 0.724 |
Schistosoma mansoni | lamin | 0.0033 | 0.2561 | 0.2353 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.