TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 286.326 | Formula: C16H18N2O3
H donors: 2 H acceptors: 3 LogP: 2.75 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCNC(=O)c1c(O)c2cccc3c2n(c1=O)CCC3
InChi: 1S/C16H18N2O3/c1-2-8-17-15(20)12-14(19)11-7-3-5-10-6-4-9-18(13(10)11)16(12)21/h3,5,7,19H,2,4,6,8-9H2,1H3,(H,17,20)
InChiKey: FIIVHHIQKMMUBG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.9347	0.9347
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0524	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0082	1	1
Brugia malayi	hypothetical protein	0.0082	1	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.2356	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.2356	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0082	1	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0425	0.1806
Loa Loa (eye worm)	trypsin family protein	0.0082	1	1
Onchocerca volvulus		0.0082	1	1
Echinococcus multilocularis	Mastin	0.0082	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0425	0.1806
Echinococcus granulosus	cpg binding protein	0.0037	0.4169	0.4169
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0425	0.1806
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.9347	0.9347
Loa Loa (eye worm)	hypothetical protein	0.0082	1	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.2356	1
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0082	1	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0524	0.0524
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0082	1	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.2356	0.5
Onchocerca volvulus		0.0082	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0082	1	1
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0082	1	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.2356	1
Onchocerca volvulus		0.0082	1	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0524	0.0524
Echinococcus multilocularis	glycoprotein Antigen 5	0.0082	1	1
Loa Loa (eye worm)	RNA binding protein	0.0076	0.9347	0.9347
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0799	0.0799
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0524	0.0524
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.2356	1
Echinococcus granulosus	Mastin	0.0082	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0425	0.1806
Onchocerca volvulus		0.0082	1	1
Echinococcus granulosus	enteropeptidase	0.0082	1	1
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.2356	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0425	0.1806
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.9347	0.9347
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.2356	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.2356	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0425	0.1806
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0082	1	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0082	1	1
Schistosoma mansoni	ap endonuclease	0.0023	0.2356	0.2356
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0425	0.1806
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.9347	0.9347
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.2356	0.2356
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0425	0.1806
Brugia malayi	Trypsin-like protease protein 5	0.0082	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0082	1	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.9347	0.9347
Trichomonas vaginalis	helicase, putative	0.0008	0.0425	0.1806
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.2356	1
Loa Loa (eye worm)	hypothetical protein	0.0082	1	1
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0082	1	1
Brugia malayi	Trypsin family protein	0.0082	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0425	0.1806
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.2356	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Echinococcus multilocularis	enteropeptidase	0.0082	1	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0524	0.0524
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0425	0.1806
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.9347	0.9347
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.2356	1
Toxoplasma gondii	exonuclease III APE	0.0023	0.2356	0.2966
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0425	0.1806
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Onchocerca volvulus		0.0082	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0082	1	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.2356	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0781	0.0781
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.9347	0.9347
Brugia malayi	Trypsin family protein	0.0082	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0425	0.1806
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0082	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0425	0.1806
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0799	0.0799
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0008	0.0425	0.1806
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.2356	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0082	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.9347	0.9347
Schistosoma mansoni	ap endonuclease	0.0023	0.2356	0.2356
Echinococcus multilocularis	transmembrane protease serine 3	0.0082	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Onchocerca volvulus		0.0035	0.3912	0.3912
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.3912	0.3912
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.9347	0.9347
Schistosoma mansoni	cpg binding protein	0.0035	0.3912	0.3912
Echinococcus granulosus	glycoprotein Antigen 5	0.0082	1	1
Loa Loa (eye worm)	hypothetical protein	0.0082	1	1
Echinococcus granulosus	transmembrane protease serine 3	0.0082	1	1
Schistosoma mansoni	cpg binding protein	0.0037	0.4169	0.4169
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0425	0.1806
Brugia malayi	CXXC zinc finger family protein	0.0035	0.3912	0.3912
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0082	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0008	0.0425	0.1806
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.2356	0.2356
Onchocerca volvulus		0.0082	1	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0005	0.0051	0.0051
Echinococcus multilocularis	cpg binding protein	0.0037	0.4169	0.4169
Mycobacterium ulcerans	hypothetical protein	0.0082	1	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.2356	0.2356
Loa Loa (eye worm)	hypothetical protein	0.0082	1	1
Schistosoma mansoni	hypothetical protein	0.0082	1	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.7945	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0425	0.1806
Loa Loa (eye worm)	hypothetical protein	0.0082	1	1
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0799	0.0799
Brugia malayi	RNA binding protein	0.0076	0.9347	0.9347
Brugia malayi	TAR-binding protein	0.0076	0.9347	0.9347
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.9347	0.9347
Brugia malayi	Trypsin family protein	0.0082	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0082	1	1
Schistosoma mansoni	hypothetical protein	0.0082	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0082	1	1
Schistosoma mansoni	cpg binding protein	0.0037	0.4169	0.4169
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.8966	0.8966

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1062 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1608771

Bibliographic References

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Detailed information for compound 1460069