Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0107 | 0.0679 | 0.0679 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.0092 | 0.0092 |
Brugia malayi | hypothetical protein | 0.0132 | 0.094 | 0.094 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0092 | 0.0092 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0051 | 0.0113 | 0.0113 |
Trichomonas vaginalis | GTP-binding protein (O) alpha subunit, gnao, putative | 0.0044 | 0.0033 | 0.0613 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0365 | 0.3333 | 1 |
Echinococcus granulosus | smad | 0.0051 | 0.0113 | 0.0113 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0061 | 0.1112 |
Echinococcus multilocularis | gtp binding protein (I) alpha 1subunit | 0.0044 | 0.0033 | 0.0033 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.0545 | 0.5791 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0679 | 0.0679 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.1015 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.0092 | 0.0092 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0061 | 0.1112 |
Brugia malayi | hypothetical protein | 0.0085 | 0.046 | 0.046 |
Brugia malayi | Smad1 | 0.0051 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | TAR-binding protein | 0.0452 | 0.4229 | 0.4229 |
Schistosoma mansoni | GTP-binding protein (I) alpha subunit gnai | 0.0044 | 0.0033 | 0.0033 |
Brugia malayi | guanine nucleotide-binding protein G-o protein alpha subunit | 0.0044 | 0.0033 | 0.0033 |
Trichomonas vaginalis | G protein (olf) alpha subunit, gnal, putative | 0.0044 | 0.0033 | 0.0613 |
Schistosoma mansoni | GTP-binding protein alpha subunit | 0.0044 | 0.0033 | 0.0033 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0132 | 0.094 | 1 |
Echinococcus granulosus | expressed protein | 0.0044 | 0.0033 | 0.0033 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0203 | 0.1672 | 0.1672 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0545 | 1 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0044 | 0.0033 | 0.0613 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0545 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0051 | 0.0113 | 0.0113 |
Brugia malayi | guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0044 | 0.0033 | 0.0033 |
Brugia malayi | hypothetical protein | 0.0044 | 0.0033 | 0.0033 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0044 | 0.0033 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0033 | 0.0033 |
Brugia malayi | TAR-binding protein | 0.0452 | 0.4229 | 0.4229 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.0092 | 0.0092 |
Brugia malayi | Guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0044 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.3333 | 0.3333 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0545 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0132 | 0.094 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0545 | 1 |
Echinococcus granulosus | gtp binding protein I alpha 1subunit | 0.0044 | 0.0033 | 0.0033 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.0545 | 0.5791 |
Giardia lamblia | Kinase, PLK | 0.0093 | 0.0545 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0092 | 0.0092 |
Brugia malayi | MH1 domain containing protein | 0.0051 | 0.0113 | 0.0113 |
Brugia malayi | MH2 domain containing protein | 0.0051 | 0.0113 | 0.0113 |
Brugia malayi | guanine nucleotide-binding protein G(o), alpha subunit, putative | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0044 | 0.0033 | 0.0033 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0156 | 0.1185 | 0.1185 |
Brugia malayi | Guanine nucleotide-binding protein alpha-12 subunit, putative | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | trimeric G-protein alpha o subunit | 0.0044 | 0.0033 | 0.0033 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0545 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.1015 | 1 | 1 |
Brugia malayi | Guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | peptidase | 0.0041 | 0.0003 | 0.0003 |
Echinococcus multilocularis | guanine nucleotide binding protein subunit | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | 0.0044 | 0.0033 | 0.0033 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0132 | 0.094 | 1 |
Onchocerca volvulus | 0.0044 | 0.0033 | 0.01 | |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0092 | 0.0092 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0051 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | GTP-binding regulatory protein alpha chain | 0.0044 | 0.0033 | 0.0033 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.0092 | 0.0092 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.0092 | 0.0092 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | kinase | 0.0047 | 0.0073 | 0.0073 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0044 | 0.0033 | 0.0033 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0132 | 0.094 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.0679 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.1015 | 1 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0051 | 0.0113 | 0.0113 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | smad1 5 8 and | 0.0051 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0452 | 0.4229 | 0.4229 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0059 | 0.0194 | 0.0194 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0044 | 0.0033 | 0.0033 |
Echinococcus granulosus | tar DNA binding protein | 0.0452 | 0.4229 | 0.4229 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0093 | 0.0545 | 0.0545 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0093 | 0.0545 | 0.0545 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0156 | 0.1185 | 0.1185 |
Schistosoma mansoni | smad | 0.0051 | 0.0113 | 0.0113 |
Schistosoma mansoni | smad1 5 8 and | 0.0051 | 0.0113 | 0.0113 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.031 | 0.2765 | 0.2765 |
Loa Loa (eye worm) | G protein alpha subunit 3 | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.1015 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0754 | 0.7321 | 0.7321 |
Echinococcus multilocularis | expressed protein | 0.0044 | 0.0033 | 0.0033 |
Brugia malayi | guanine nucleotide-binding protein alpha-7 subunit, putative | 0.0044 | 0.0033 | 0.0033 |
Echinococcus multilocularis | tar DNA binding protein | 0.0452 | 0.4229 | 0.4229 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0452 | 0.4229 | 0.4229 |
Loa Loa (eye worm) | RNA binding protein | 0.0452 | 0.4229 | 0.4229 |
Echinococcus granulosus | guanine nucleotide binding protein subunit | 0.0044 | 0.0033 | 0.0033 |
Brugia malayi | Guanine nucleotide-binding protein alpha-6 subunit, putative | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.0194 | 0.0194 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0093 | 0.0545 | 0.0545 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0044 | 0.0033 | 0.0613 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0093 | 0.0545 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0132 | 0.094 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.094 | 0.094 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0545 | 1 |
Brugia malayi | G-protein alpha subunit | 0.0044 | 0.0033 | 0.0033 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.1015 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0545 | 1 |
Brugia malayi | RNA binding protein | 0.0452 | 0.4229 | 0.4229 |
Loa Loa (eye worm) | guanine nucleotide-binding protein alpha-6 subunit | 0.0044 | 0.0033 | 0.0033 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0044 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0092 | 0.0092 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0044 | 0.0033 | 0.0613 |
Leishmania major | hypothetical protein, conserved | 0.0132 | 0.094 | 1 |
Schistosoma mansoni | GTP-binding protein (q) alpha-11 subunit gna11 | 0.0044 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0033 | 0.0033 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0051 | 0.0113 | 0.0113 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0132 | 0.094 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0365 | 0.3333 | 0.3333 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0093 | 0.0545 | 0.0545 |
Echinococcus multilocularis | smad | 0.0051 | 0.0113 | 0.0113 |
Schistosoma mansoni | Smad4 | 0.0051 | 0.0113 | 0.0113 |
Trypanosoma brucei | polo-like protein kinase | 0.0093 | 0.0545 | 0.5791 |
Loa Loa (eye worm) | Smad1 | 0.0051 | 0.0113 | 0.0113 |
Schistosoma mansoni | tar DNA-binding protein | 0.0452 | 0.4229 | 0.4229 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0093 | 0.0545 | 0.5791 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0051 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.2765 | 0.2765 |
Trichomonas vaginalis | GTP-binding protein (z) alpha subunit, gnaz, putative | 0.0044 | 0.0033 | 0.0613 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0093 | 0.0545 | 0.1634 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0754 | 0.7321 | 0.7321 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0051 | 0.0113 | 0.0113 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0051 | 0.0113 | 0.0113 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0092 | 0.0092 |
Echinococcus granulosus | Smad4 | 0.0051 | 0.0113 | 0.0113 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | smad1 5 8 and | 0.0051 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0754 | 0.7321 | 0.7321 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.1015 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.1015 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.1015 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0452 | 0.4229 | 0.4229 |
Onchocerca volvulus | 0.0044 | 0.0033 | 0.01 | |
Schistosoma mansoni | GTP-binding protein alpha subunit | 0.0044 | 0.0033 | 0.0033 |
Trichomonas vaginalis | GTP-binding protein (q) alpha-11 subunit, gna11, putative | 0.0044 | 0.0033 | 0.0613 |
Echinococcus multilocularis | Smad4 | 0.0051 | 0.0113 | 0.0113 |
Brugia malayi | GTP-binding regulatory protein alpha chain - starfish, putative | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0092 | 0.0092 |
Echinococcus granulosus | guanine nucleotide binding protein subunit | 0.0044 | 0.0033 | 0.0033 |
Onchocerca volvulus | 0.0044 | 0.0033 | 0.01 | |
Brugia malayi | MH1 domain containing protein | 0.0051 | 0.0113 | 0.0113 |
Schistosoma mansoni | GTP-binding protein (q) alpha-11 subunit gna11 | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | tar DNA-binding protein | 0.0452 | 0.4229 | 0.4229 |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | 0.0044 | 0.0033 | 0.0033 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0203 | 0.1672 | 0.1672 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0059 | 0.0194 | 0.0194 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0132 | 0.094 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein subunit | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | tar DNA-binding protein | 0.0452 | 0.4229 | 0.4229 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0044 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | guanine nucleotide-binding protein alpha-12 subunit | 0.0044 | 0.0033 | 0.0033 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.0545 | 0.0545 |
Loa Loa (eye worm) | heterotrimeric G protein alpha subunit | 0.0044 | 0.0033 | 0.0033 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0044 | 0.0033 | 0.0613 |
Schistosoma mansoni | tar DNA-binding protein | 0.0452 | 0.4229 | 0.4229 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED25 (functional) | = 0.4 mg kg-1 day-1 | Effective dose of the compound to reduce 25% of glucose levels in blood | ChEMBL. | 1635060 |
ED25 (functional) | = 0.9 mg kg-1 day-1 | Effective dose to reduce 25% of triglyceride levels in plasma | ChEMBL. | 1635060 |
ED25 (functional) | = 0.9 mg kg-1 day-1 | Effective dose to reduce 25% of triglyceride levels in plasma | ChEMBL. | 1635060 |
Reduction (functional) | = 41 % | Maximum reduction in plasma triglyceride levels in KKA mice at a dosage of 0.001% in diet | ChEMBL. | 1635060 |
Reduction (functional) | = 41 % | Maximum reduction in plasma triglyceride levels in KKA mice at a dosage of 0.001% in diet | ChEMBL. | 1635060 |
Reduction (functional) | = 50 % | Maximum reduction in blood glucose levels in KKA mice at a dosage of 0.001% in diet | ChEMBL. | 1635060 |
Reduction (functional) | = 50 % | Maximum reduction in blood glucose levels in KKA mice at a dosage of 0.005% in diet | ChEMBL. | 1635060 |
Reduction (functional) | = 50 % | Maximum reduction in blood glucose levels in KKA mice at a dosage of 0.001% in diet | ChEMBL. | 1635060 |
Reduction (functional) | = 50 % | Maximum reduction in blood glucose levels in KKA mice at a dosage of 0.005% in diet | ChEMBL. | 1635060 |
Reduction (functional) | = 69 % | Maximum reduction in plasma triglyceride levels in KKA mice at a dosage of 0.005% in diet | ChEMBL. | 1635060 |
Reduction (functional) | = 69 % | Maximum reduction in plasma triglyceride levels in KKA mice at a dosage of 0.005% in diet | ChEMBL. | 1635060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.