Detailed information for compound 1460774

Basic information

Technical information
  • TDR Targets ID: 1460774
  • Name: N-(3-cyano-4-ethyl-5-methylthiophen-2-yl)-3-m ethyl-1,2-oxazole-5-carboxamide
  • MW: 275.326 | Formula: C13H13N3O2S
  • H donors: 1 H acceptors: 3 LogP: 3.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(NC(=O)c2onc(c2)C)sc(c1CC)C
  • InChi: 1S/C13H13N3O2S/c1-4-9-8(3)19-13(10(9)6-14)15-12(17)11-5-7(2)16-18-11/h5H,4H2,1-3H3,(H,15,17)
  • InChiKey: HMCBGXYFLYODIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-cyano-4-ethyl-5-methyl-2-thienyl)-3-methyl-isoxazole-5-carboxamide
  • N-(3-cyano-4-ethyl-5-methyl-2-thienyl)-3-methyl-5-isoxazolecarboxamide
  • N-(3-cyano-4-ethyl-5-methyl-thiophen-2-yl)-3-methyl-1,2-oxazole-5-carboxamide
  • MLS000118381
  • SMR000095323

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0086 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.0761 0.0936
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0358 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Loa Loa (eye worm) hypothetical protein 0.007 0.0761 0.0936
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.0761 0.0936
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0313 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0761 0.0936
Brugia malayi hypothetical protein 0.0037 0.0361 0.0434
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.0761 0.0936
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0313 0.0299
Loa Loa (eye worm) hypothetical protein 0.0037 0.0361 0.0434
Brugia malayi nuclear hormone receptor 0.007 0.0761 0.0936
Brugia malayi Death domain containing protein 0.0014 0.0086 0.009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0259 0.3115
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0695 0.0852
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0313 0.0374
Loa Loa (eye worm) hypothetical protein 0.0037 0.0361 0.0434
Loa Loa (eye worm) hypothetical protein 0.0037 0.0356 0.0429
Echinococcus granulosus dnaJ subfamily B 0.0408 0.4847 0.4839
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.0761 0.0936
Brugia malayi conserved hypotetical protein 0.0033 0.0313 0.0374
Brugia malayi Protein kinase domain containing protein 0.0014 0.0086 0.009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0356 0.0343
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0036 0.0022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0259 0.3115
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0259 0.7121
Onchocerca volvulus 0.0029 0.0259 0.029
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.0761 0.0748
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.0761 0.0748
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0761 0.0748
Onchocerca volvulus Bile acid receptor homolog 0.007 0.0761 0.0886
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.0761 0.0748
Schistosoma mansoni hypothetical protein 0.0408 0.4847 0.4839
Echinococcus granulosus death domain containing protein 0.0014 0.0086 0.0072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0157 0.1965
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0358 1
Onchocerca volvulus 0.0287 0.3384 0.3997
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0313 0.0374
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0751 0.9376
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0361 0.0347
Loa Loa (eye worm) histone methyltransferase 0.001 0.0036 0.0027
Schistosoma mansoni retinoic acid receptor RXR 0.0168 0.195 0.1939
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0014 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0177
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.0761 0.0748
Brugia malayi Steroid receptor seven-up type 2 0.007 0.0761 0.0936
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0131 0.1502 0.149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0259 0.3237
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0313 0.0299
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0259 0.0307
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0086 0.0085
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0171 0.2142
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0358 1
Brugia malayi Inositol-1 0.0037 0.0358 0.0431
Brugia malayi hypothetical protein 0.0033 0.0313 0.0374
Brugia malayi tailless protein 0.0033 0.0313 0.0374
Schistosoma mansoni thyroid hormone receptor 0.007 0.0761 0.0748
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.0761 0.0748
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0761 0.0748
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0177
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.2706 0.3373
Brugia malayi CXXC zinc finger family protein 0.0029 0.0259 0.0307
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0761 0.0936
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0313 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.0761 0.0936
Schistosoma mansoni cpg binding protein 0.003 0.0279 0.0265
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0751 0.9387
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0585 0.7262
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0259 0.824
Loa Loa (eye worm) hypothetical protein 0.007 0.0761 0.0936
Schistosoma mansoni thyroid hormone receptor 0.007 0.0761 0.0748
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0259 0.0307
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0356 0.0343
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.0761 0.0748
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0313 0.0299
Schistosoma mansoni inositol monophosphatase 0.0037 0.0358 0.0344
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0259 0.3115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0157 0.1965
Plasmodium vivax SET domain protein, putative 0.0037 0.0356 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0635 0.0622
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0313 0.0299
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0259 0.3237
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.0761 0.0748
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0313 0.0299
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0259 0.3115
Onchocerca volvulus 0.0037 0.0356 0.0406
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0358 0.1021
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0034 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0259 0.0307
Onchocerca volvulus 0.007 0.0761 0.0886
Brugia malayi ecdysteroid receptor 0.007 0.0761 0.0936
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0761 0.0748
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0014 0.0177
Brugia malayi Uncoordinated protein 44 0.0014 0.0086 0.009
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0313 0.0374
Brugia malayi follicle stimulating hormone receptor 0.0231 0.2706 0.3373
Schistosoma mansoni hypothetical protein 0.0014 0.0086 0.0072
Loa Loa (eye worm) hypothetical protein 0.007 0.0761 0.0936
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.0761 0.0748
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0259 0.7121
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0014 0.0177
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0361 0.0434
Loa Loa (eye worm) hypothetical protein 0.007 0.0761 0.0936
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.0761 0.0748
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0313 0.0299
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0014 0.0177
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0313 0.0299
Brugia malayi hypothetical protein 0.0037 0.0361 0.0434
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0313 0.0299
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3383 1
Schistosoma mansoni nuclear hormone receptor 0.007 0.0761 0.0748
Schistosoma mansoni hypothetical protein 0.0205 0.2389 0.2379
Brugia malayi nuclear hormone receptor 0.0668 0.7997 1
Brugia malayi Pre-SET motif family protein 0.0037 0.0356 0.0429
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0358 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.0761 0.0936
Loa Loa (eye worm) hypothetical protein 0.0021 0.0171 0.0197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0157 0.1965
Loa Loa (eye worm) hypothetical protein 0.0021 0.0171 0.0197
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0311 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0185 0.0214
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.08 0.0787
Brugia malayi ecdysone receptor 0.0033 0.0313 0.0374
Schistosoma mansoni zinc finger protein 0.0033 0.0313 0.0299
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0259 0.824
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0751 0.0738
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.08 0.0787
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0313 0.0299
Loa Loa (eye worm) hypothetical protein 0.007 0.0761 0.0936
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0313 0.0374
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0259 0.3115
Brugia malayi nuclear receptor NHR-88 0.007 0.0761 0.0936
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0356 0.0343
Echinococcus granulosus cpg binding protein 0.003 0.0279 0.0265
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.08 1
Brugia malayi steroid hormone receptor 0.007 0.0761 0.0936
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0177
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.0761 0.0748
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0358 0.4375
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0259 0.3115
Schistosoma mansoni cpg binding protein 0.0029 0.0259 0.0245
Schistosoma mansoni nuclear receptor 0.0033 0.0313 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.0761 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.0761 0.0936
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0361 0.0434
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0761 0.0936
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0356 0.0343
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0313 0.0299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.0761 0.0936
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0171 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0333 0.0319
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0087 0.0073
Loa Loa (eye worm) hypothetical protein 0.007 0.0761 0.0936
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0086 0.009
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0801 0.0788
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0358 0.1021
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0171 0.2
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.0761 0.0748
Loa Loa (eye worm) hypothetical protein 0.007 0.0761 0.0936
Loa Loa (eye worm) hypothetical protein 0.0021 0.0171 0.0197
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.0761 0.0748
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0761 0.0936
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0171 0.4594
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.0761 0.0936
Onchocerca volvulus 0.0029 0.0259 0.029
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0668 0.7997 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0358 0.0344
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0259 0.3115
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.0761 0.0748
Echinococcus granulosus tumor protein p63 0.0408 0.4852 0.4844
Loa Loa (eye worm) steroid hormone receptor 0.007 0.0761 0.0936
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0311 0.3891
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0313 0.0374
Loa Loa (eye worm) hypothetical protein 0.007 0.0761 0.0936
Echinococcus granulosus Ankyrin 0.0014 0.0087 0.0073
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0801 0.0788
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Schistosoma mansoni nuclear receptor 0.0033 0.0313 0.0299
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0761 0.0748
Loa Loa (eye worm) hypothetical protein 0.006 0.0635 0.0778
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0171 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0761 0.0748
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0358 0.0344
Brugia malayi Pre-SET motif family protein 0.0252 0.2962 0.3693
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.0761 0.0936
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0259 0.7121
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0361 0.0347
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0086 0.009
Echinococcus multilocularis FTZ F1 alpha 0.007 0.0761 0.0748
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0313 0.0354
Echinococcus multilocularis tumor protein p63 0.0408 0.4852 0.4844
Echinococcus granulosus geminin 0.0205 0.2389 0.2379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.0761 0.0936
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0086 0.0072
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0086 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0356 0.0343
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0358 0.4375
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.0761 0.0748
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0313 0.0299
Loa Loa (eye worm) hypothetical protein 0.0029 0.0259 0.0307
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0036 0.0022
Brugia malayi nuclear receptor RXR 0.0037 0.0361 0.0434
Loa Loa (eye worm) hypothetical protein 0.0037 0.0361 0.0434
Onchocerca volvulus 0.0013 0.0071 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0313 0.0299
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0751 0.9376
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0259 0.3115
Schistosoma mansoni hypothetical protein 0.0205 0.2389 0.2379
Onchocerca volvulus 0.006 0.0635 0.0737
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi hypothetical protein 0.0033 0.0313 0.0374
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0259 0.0307
Loa Loa (eye worm) hypothetical protein 0.0029 0.0259 0.0307
Echinococcus multilocularis geminin 0.0205 0.2389 0.2379
Brugia malayi nuclear receptor NHR-88 0.0033 0.0313 0.0374
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0014 0.0177
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.08 0.0787
Loa Loa (eye worm) hypothetical protein 0.0037 0.0361 0.0434
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0751 0.0738
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0356 0.0343
Echinococcus multilocularis Ankyrin 0.0014 0.0087 0.0073
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Loa Loa (eye worm) hypothetical protein 0.0029 0.0259 0.0307
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0014 0.0177
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0313 0.0299
Brugia malayi Cytochrome P450 family protein 0.0023 0.0185 0.0214
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0751 0.0738
Echinococcus granulosus FTZ F1 alpha 0.007 0.0761 0.0748
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.0761 0.0936
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0014 0.0177
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.0361 0.0434
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.08 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Loa Loa (eye worm) hypothetical protein 0.0021 0.0171 0.0197
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0157 0.1965
Schistosoma mansoni cpg binding protein 0.003 0.0279 0.0265
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.08 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0663 0.065
Loa Loa (eye worm) hypothetical protein 0.0033 0.0313 0.0374
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0313 0.0299
Schistosoma mansoni netrin receptor unc5 0.0014 0.0086 0.0072
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0313 0.0354
Brugia malayi nuclear receptor RXR 0.0033 0.0313 0.0374
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0358 0.4375
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0705 0.8445 1
Onchocerca volvulus 0.0033 0.0313 0.0354
Onchocerca volvulus 0.0033 0.0313 0.0354
Loa Loa (eye worm) DR-78 0.0033 0.0313 0.0374
Schistosoma mansoni coup transcription factor 0.007 0.0761 0.0748
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.0761 0.0886
Loa Loa (eye worm) hypothetical protein 0.0014 0.0086 0.009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.0761 0.0748
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0259 0.3115
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0751 0.0923
Echinococcus multilocularis cpg binding protein 0.003 0.0279 0.0265
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0358 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.08 0.0787
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.08 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0361 0.0434
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0358 0.1021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.08 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0014 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0761 0.0936
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.0761 0.0748
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.0761 0.0936
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.0092
Loa Loa (eye worm) inositol-1 0.0037 0.0358 0.0431
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0086 0.0072
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0086 0.0072
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0751 0.9376
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0761 0.0936
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.0761 0.0936
Loa Loa (eye worm) hypothetical protein 0.0021 0.0171 0.0197
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0356 0.4354
Schistosoma mansoni inositol monophosphatase 0.0037 0.0358 0.0344
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.4847 0.4839
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.08 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.0761 0.0748
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0313 0.0374
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0356 0.0343
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0168 0.195 0.1939
Mycobacterium ulcerans hypothetical protein 0.0029 0.0259 0.3115
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0361 0.0347
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0313 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.0761 0.0936
Brugia malayi nuclear receptor NHR-67 0.0033 0.0313 0.0374
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0361 0.0347
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0259 0.3115
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.0761 0.0748
Loa Loa (eye worm) hypothetical protein 0.0635 0.7597 0.9498
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0313 0.0299
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2962 0.3693

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Firefly Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 2309 (Probe Summary for Inhibitors and Stabilizers of Firefly Luciferase)] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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